Intravascular Hemolysis Associated with Liver Disease in a Horse with Marked Neutrophil Hypersegmentation

Ramaiah, Shashi K.; Harvey, John W.; Giguère, Steeve; Franklin, Robert P.; Crawford, P. Cynda

doi:10.1111/j.1939-1676.2003.tb02463.x

Cited by 16 publications

(12 citation statements)

References 12 publications

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“…Under this hypothesis, the large total volume of blood product administered to foals with liver failure would be the consequence rather than the cause of liver failure. Severe hemolysis from liver failure is very rare but it has been reported usually near the time of death in adult horses 16,17 . However, the fact that none of the many previously reported cases of fulminant liver failure in foals had anemia or hemolysis, 10,12 and the similarity between the histologic lesions seen in the present study and those reported in foals administered iron fumarate 12 make this hypothesis much less likely.…”

Section: Discussionsupporting

confidence: 39%

“…Severe hemolysis from liver failure is very rare but it has been reported usually near the time of death in adult horses. 16,17 However, the fact that none of the many previously reported cases of fulminant liver failure in foals had anemia or hemolysis, 10,12 and the similarity between the histologic lesions seen in the present study and those reported in foals administered iron fumarate 12 make this hypothesis much less likely. Finally, transfusion associated graft versus host disease is a rare but often fatal complication of blood transfusion in humans.…”

Section: Discussionmentioning

confidence: 67%

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Factors Associated with Outcome in Foals with Neonatal Isoerythrolysis (72 Cases, 1988–2003)

Polkes

Giguère

Lester³

et al. 2008

Veterinary Internal Medicne

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Background: Neonatal foals with isoerythrolysis (NI) often die, but the risk factors for death have not been identified. Objectives: To identify factors associated with outcome in foals with NI and to identify factors associated with death from liver failure or kernicterus in the same population.Animals: Seventy-two foals with NI examined at referral institutions. Methods: Retrospective case series. Information on signalment, clinical examination findings, laboratory testing, treatment, complications, outcome, and necropsy results were obtained.Results: The overall survival rate was 75% (54 of 72). Liver failure (n 5 7), kernicterus (n 5 6), and complications related to bacterial sepsis (n 5 3) were the 3 most common reasons for death or euthanasia. The number of transfusions with blood products was the factor most strongly associated with nonsurvival in a multivariate logistic regression model. The odds of liver failure developing in foals receiving a total volume of blood products ! 4.0 L were 19.5 (95% confidence intervals [CI]: 2.13-178) times higher than that of foals receiving a lower volume (P 5 .009). The odds of kernicterus developing in foals with a total bilirubin ! 27.0 mg/dL were 17.0 (95% CI: 1.77-165) times higher than that of foals with a lower total bilirubin (P 5 .014).Conclusions and Clinical Importance: Development of liver failure, kernicterus, and complications related to bacterial sepsis are the most common causes of death in foals with NI. Foals administered a large volume of blood products are at greater risk for developing liver failure.

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Section: Discussionsupporting

confidence: 39%

Section: Discussionmentioning

confidence: 67%

Factors Associated with Outcome in Foals with Neonatal Isoerythrolysis (72 Cases, 1988–2003)

Polkes

Giguère

Lester³

et al. 2008

Veterinary Internal Medicne

View full text Add to dashboard Cite

show abstract

“…Photos in previous articles showed hypersegmented equine neutrophils that looked the same as those in our 2 Quarter horses 5,6. Three hypersegmented neutrophils in a 6‐year‐old quarter horse had 9–10 lobes 5.…”

supporting

confidence: 65%

“…Three hypersegmented neutrophils in a 6‐year‐old quarter horse had 9–10 lobes 5. Five hypersegmented neutrophils in a 10‐year‐old quarter horse had 7–10 lobes 6. Two similar hypersegmented neutrophils had 6–10 lobes in an Internet photo of an horse, but the breed was not indicated 4.…”

mentioning

confidence: 96%