Intravascular brachytherapy with radioactive stents produced by ion implantation

Golombeck, M.-A.; Heise, S.; Schloesser, K.; Schuessler, Bernhard; Schweickert, H.

doi:10.1016/s0168-583x(03)00806-1

Cited by 13 publications

(6 citation statements)

References 4 publications

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“…61 Hehrlein et al investigated the influence of a b-particle emitting radioisotope ( 32 P) with a halflife time of 14?4 days and a maximum energy of 1?711 MeV ion implanted into Palmaz-Schatz stents. 64 The neointima formation in rabbit iliac arteries is markedly suppressed in a dose dependant manner. Pure b-particle emitting stents are very effective in inhibiting neointima formation after angioplasty in rabbits.…”

Section: Chemical Vapour Deposition Polymerisation (Cvd-polymerisation)mentioning

confidence: 98%

Review of stent coating strategies: Clinical insights

Sydow-Plum¹,

Tabrizian²

2008

Materials Science and Technology

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Despite advances in stent design, expansion techniques and anti-thrombotic agents to improve pharmacological control of subacute thrombosis (SAT) and to reduce to 2 the occlusive thrombosis rates, a significant risk of mortality associated with thrombotic vascular occlusion due to the adhesion of blood constituents remains a problem for patients with more complex lesions. The adhesion process is greatly governed by the surface characteristics, mainly the surface chemical composition, surface morphology, presence of charge, surface wettability and surface roughness. Surface chemical inertness (reduced interaction with chemicals and biological components) subsequently became the primary criteria which guided the development of non thrombotic stents as well as other blood-contacting materials. A number of strategies have been adopted in an effort to coat the stent with or without the use of a drug delivery system, to overcome the thrombus formation, to minimize the stent occlusion and to improve the overall hemocompatibility of the device. This paper aims at reviewing the clinical outcomes of main nonpharmaceutical stent coating procedures and their clinical outcomes. New stents which combine the anti-thrombotic coating with the drug delivery ability, such as radioactive stents, degradable stents and some new challenging trends which are mostly at research and development stage for stent surface coatings are also introduced.

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Section: Chemical Vapour Deposition Polymerisation (Cvd-polymerisation)mentioning

confidence: 98%

Review of stent coating strategies: Clinical insights

Sydow-Plum¹,

Tabrizian²

2008

Materials Science and Technology

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“…This involves placing implants in the form of seeds, wires or pellets directly into the tumor. Such implants may be temporary or permanent depending on the implant and the tumor itself [36][37][38]. Brachytherapy is used to treat the following cancers: uterus, cervix, breast, prostate, intraocular, skin, thyroid, bone, brain, and other cancers [39,40].…”

Section: Radiobiological Characteristicsmentioning

confidence: 99%

Internal radiotherapy techniques using radiolanthanide praseodymium-142: a review of production routes, brachytherapy, unsealed source therapy

Bakht

Sadeghi²

2011

Ann Nucl Med

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Radionuclides of rare earth elements are gaining importance as emerging therapeutic agents in nuclear medicine. β(-)-particle emitter 142Pr [T (1/2) = 19.12 h, E(-)β = 2.162 MeV (96.3%), Eγ = 1575 keV (3.7%)] is one of the praseodymium-141 (100% abundant) radioisotopes. Production routes and therapy aspects of 142Pr will be reviewed in this paper. However, 142Pr produces via 141Pr(n, γ) 142Pr reaction by irradiation in a low-fluence reactor; 142Pr cyclotron produced, could be achievable. 142Pr due to its high β(-)-emission and low specific gamma γ-emission could not only be a therapeutic radionuclide, but also a suitable radionuclide in order for biodistribution studies. Internal radiotherapy using 142Pr can be classified into two sub-categories: (1) unsealed source therapy (UST), (2) brachytherapy. UST via 142Pr-HA and 142Pr-DTPA in order for radiosynovectomy have been proposed. In addition, 142Pr Glass seeds and 142Pr microspheres have been utilized for interstitial brachytherapy of prostate cancer and intraarterial brachytherapy of arteriovenous malformation, respectively.

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“…In the past, brachytherapy was carried out mostly with radium or radon sources. [42][43][44][45][46][47][48][49] Currently, use of artificially produced radionuclides such as 103 Pd [50] and 125 I [51] is rapidly increasing [ Table 2]. This involves placing implants in the form of seeds, wires or pellets directly into the tumor.…”

Section: Brachythrapymentioning

confidence: 99%

“…Brachytherapy is used to treat the following cancers: uterus, cervix, breast, prostate, intraocular, skin, thyroid, bone, brain and other cancers. [42][43][44][45][46][47][48][49][50][51][52] Endoradiotherapy (targeted radionuclide therapy) External beam and brachytherapy emissions are composed of photons, whereas radiations of interest in radionuclide therapy 4) The nanometer-to-micrometer range Auger electrons are emitted in close proximity to the nuclear DNA and induce highly cytotoxic DNA double strand breaks). [90,94] are particulate.…”

Section: Brachythrapymentioning

confidence: 99%

External and internal radiation therapy: Past and future directions

2010

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Cancer is a leading cause of morbidity and mortality in the modern world. Treatment modalities comprise radiation therapy, surgery, chemotherapy and hormonal therapy. Radiation therapy can be performed by using external or internal radiation therapy. However, each method has its unique properties which undertakes special role in cancer treatment, this question is brought up that: For cancer treatment, whether external radiation therapy is more efficient or internal radiation therapy one? To answer this question, we need to consider principles and structure of individual methods. In this review, principles and application of each method are considered and finally these two methods are compared with each other.

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Intravascular brachytherapy with radioactive stents produced by ion implantation

Cited by 13 publications

References 4 publications

Review of stent coating strategies: Clinical insights

Review of stent coating strategies: Clinical insights

Internal radiotherapy techniques using radiolanthanide praseodymium-142: a review of production routes, brachytherapy, unsealed source therapy

External and internal radiation therapy: Past and future directions

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