Intravascular brachytherapy for peripheral vascular disease

Abstract

AHRQ 2013 Agency for Healthcare Research and Quality. Treatment strategies for patients with peripheral artery disease. E ective health care programme. Comparative e ectiveness review number 118.

HMGB1-Driven Inflammation and Intimal Hyperplasia After Arterial Injury Involves Cell-Specific Actions Mediated by TLR4

“…Vascular interventions, such as surgical bypass procedures, endarterectomy, 1 peripheral artery brachytherapy, 2,3 angioplasty, and stent placement for arterial occlusive disease, can fail because of restenosis. 4,5 These interventional procedures result in endothelial denudation with intimal and medial damage, which induces substantial local inflammation.…”

Construction of multifunctional organic–inorganic hybrid Bi2S3–PLGA capsules for highly efficient ultrasound-guided radiosensitization of brachytherapy

“…Based on the tumor growth curve and the analysis of Ki67 of tumor cells, it can be concluded that the fabricated Bi 2 S 3 -PLGA capsules can function as the efficient in vivo radiation sensitizer for enhancing the therapeutic efficiency of brachytherapy. In addition, the in situ intratumor administration was adopted because brachytherapy typically implants the radiation source into the tumor clinically, [1][2][3][4] which can maximally accumulate the Bi 2 S 3 -PLGA capsules and P-32 radiation source within the tumors. Thus, the administration dose can be much lower than traditional systemic administration, such as intravenous injection, causing the signicantly reduced toxicities to mice.…”

“…Brachytherapy has been widely used as an efficient therapeutic modality against prostate carcinoma due to its unique advantage of long-term and durable radiation effect by placing the radiation source directly inside the tumor. [1][2][3][4] The implanted radiation source, containing different formations, such as colloids, seeds, and containers, can deliver a signicantly higher radiation dose to the prostate carcinoma with mitigated side-effects to the surrounding normal tissues compared to the traditional external radiation therapy. To increase the accuracy of radiation source placement and ensure that the tumor can receive efficient concentration and distribution of seeds throughout the prostate tumor, the in situ ultrasound imaging was generally applied, by which the catheter can be monitored to guide the implanting process.…”

High dose-rate brachytherapy for the treatment of lower extremity in-stent restenosis

“…27 In the peripheral arterial tree, EVBT has been used to treat de novo, restenosis, and ISR lesions. 28 Prior studies of EVBT for prophylaxis or treatment of ISR with EVBT are compared in Table IV were hampered by low enrollment and ultimately halted before completion. 29 Two more recent studies investigating the role of EVBT for ISR for infrainguinal arterial occlusive disease have shown more promising results.…”