Intravaginal Progesterone Insert to Synchronize Return to Estrus of Previously Inseminated Dairy Cows

Abstract

An intravaginal progesterone insert (CIDR insert; 1.38 g of progesterone) was evaluated for synchronization of returns to estrus (SR), conception rate (CR), and pregnancy rate (PR) in dairy cows previously artificially inseminated (AI). Healthy, nonpregnant, lactating Holstein cows, > or = 40 and < or = 150 d postpartum at eight commercial farms were used. Cows detected in estrus and receiving AI 2, 3, or 4 d after one injection of PGF2alpha (25 mg) were assigned as either controls (n = 945), or to receive a CIDR insert (n = 948) for 7 d (14 to 21 +/- 1 d after AI). Cows were observed for returns to estrus from 18 to 26 +/- 1 d after initial AI (resynchrony period) and were reinseminated if in estrus. Vaginal mucus on CIDR inserts (97.3% retention) at removal was scored: 1 = no mucus; 2 = clear; 3 = cloudy; 4 = yellow; and 5 = red or brown. Percentage of cows in estrus (SR) during the 3 d after CIDR insert removal was contrasted to the highest 3-d cumulative percentage in estrus for controls. Cows conceiving to initial AI were omitted in calculations of SR, CR, and PR during resynchrony. Mucous scores of 3 or 4 (mild irritation) were observed in 65% of cows and a score of 5 (more severe irritation) was observed in 2%; otherwise, health was unaffected. The PR to initial AI was lower for cows subsequently receiving CIDR inserts than for controls (32.7 vs. 36.7%). The CIDR insert increased SR (34.1 vs. 19.3% in 3 d) and overall estrus detection (43% in 4 d vs. 36% in 9 d) compared with controls. For the 9-d resynchrony period, CR and PR for CIDR-treated (26.7, 12.2%) and control (30.9, 11.1%) cows did not differ significantly. The CIDR inserts improved synchrony of returns to estrus, slightly reduced PR to initial AI, but did not affect CR or PR to AI during the resynchrony period.

The effect of a progesterone (P4) intravaginal device (CIDR) on resynchronisation of oestrus and embryonic loss in previously timed inseminated dairy heifers

“…After CIDR removal, 58.1% of the heifers that failed to breed from TAI showed oestrus within 1.9 days and 77.4% within 2.4 days for CGPG group compared to 23.8% and 57.1% heifers, which showed oestrus within 2.9 and 6.7 days, respectively, for the control group. Similar observations were found in lactating dairy cows (Chenault et al, 2003;Alnimer and Lubbadeh, 2008), beef heifers (Colazo et al, 2006) and in dairy heifers (Van Cleeff et al, 1996;Hanlon et al, 1997;Rivera et al, 2005).…”

“…The results of this study are in agreement with Rivera et al (2005) who reported that PR to second AI was higher for resynchronised than for control heifers. On the other hand, similar PRs were found after the second AI between resynchronised cows with CIDR compared to control (Chenault et al, 2003).…”

“…Meanwhile, synchronisation of oestrus in dairy heifers, using gonadotropin-releasing hormone (GnRH) and prostaglandin F2-alpha (PGF 2a ) 7 days apart followed by AI on observed oestrus, was more efficient than various protocols using TAI (Peckelhoff et al, 2000). Cows and heifers that fail to become pregnant following TAI return to oestrus 15 to 25 days after insemination (Van Cleeff et al, 1996;Chenault et al, 2003). Hence, intensive oestrus detection and reinsemination of heifers returning to oestrus is required to maximise the number of heifers becoming pregnant to AI.…”

“…Hence, intensive oestrus detection and reinsemination of heifers returning to oestrus is required to maximise the number of heifers becoming pregnant to AI. Progesterone-releasing (P 4 ) intravaginal device (CIDR: controlled internal drug-releasing dispenser) for 7 days can be used to synchronise the return to oestrus in non-pregnant cows (Chenault et al, 2003;Alnimer and Lubbadeh, 2008).…”

Kısa Süreli PRID Uygulanan Düvelerde Bazı Oksidatif Stres Parametrelerinin Değerlendirilmesi

“…Synchronization methods include the use of progesterone-releasing intravaginal devices (PRID or CIDR), ear implants and feed additives [16][17][18] . It is known that the removal of progesterone-releasing intravaginal devices irritates the tissue, causing vaginitis, which in turn causes the animal to undergo stress [19][20][21] . For example, Aksu et al [22] conducted a study on cows in which the use of CIDR in the synchronization protocol resulted in higher MDA levels than in those cows for which the devices were not used.…”