Intrauterine Tobacco Smoke Exposure and Congenital Heart Defects

Forest, Sharron; Priest, Sandra

doi:10.1097/jpn.0000000000000153

Cited by 16 publications

(8 citation statements)

References 38 publications

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“…Cigarette smoking is perhaps the single most avoidable cause of adverse pregnancy outcomes, increasing the risk for low birth weight, underdeveloped organs, congenital anomalies, preterm birth, fetal mortality, and morbidity (Baba, Wikstrom, Stephansson, & Cnattingius, ; CDC, ; Forest & Priest, ; Harrod, Reynolds, Chasan‐Taber, et al, ; Holbrook, ; Kleinman, Pierre, Madans, et al, ; Mund, Louwen, Klingelhoefer, & Gerber, ; Rogers, ; Rogers, ; Shaw, Carmichael, Vollstet, et al, ). Moreover, maternal smoking during pregnancy has been associated with adverse neurobehavioral, cardiovascular and respiratory consequences in offspring, many of which persist into adulthood (CDC, ).…”

Section: Introductionmentioning

confidence: 99%

Developmental toxicity of e‐cigarette aerosols

Greene

Pisano

2019

Birth Defects Research

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Maternal smoking during pregnancy represents a major public health concern increasing the risk for low birth weight, congenital anomalies, preterm birth, fetal mortality, and morbidity. In an effort to diminish adverse developmental effects of exposure to cigarette smoking, pregnant women, and women of reproductive age, are increasingly turning to electronic nicotine delivery systems (ENDS), such as e‐cigarettes, as an alternative. Given that health risks associated with ENDS use during pregnancy are largely unknown, there is an acute need to determine risks vs. benefits of e‐cigarette use by pregnant women. While the most recent Surgeon General's Report on the “Health Consequences of Smoking” states that “the evidence is sufficient to infer that nicotine adversely affects maternal and fetal health during pregnancy, contributing to multiple adverse outcomes,” it remains unclear whether use of ENDS represents a “safer alternative” to tobacco smoking during pregnancy. This is due, in part, to the lack of sufficient and conclusive evidence concerning whether or not maternal e‐cigarette use adversely affects embryonic/fetal development. While several recent developmental studies have challenged the safety of nicotine inhalation via ENDS, the true risks of smoking e‐cigarettes during the first trimester of pregnancy—the period of organogenesis—are largely unknown. Moreover, evidence is emerging that even nicotine‐free e‐cigarette aerosols may harm the developing conceptus, suggesting that components of e‐cigarette liquid, including flavorings, may be developmentally toxicity. Focused human epidemiological analyses, and carefully designed animal studies are critically needed to address the question of the safety of ENDS use during pregnancy.

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Section: Introductionmentioning

confidence: 99%

Developmental toxicity of e‐cigarette aerosols

Greene

Pisano

2019

Birth Defects Research

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“…It is worthy to note that the risk effect of SHS on circulatory system defects was significant (OR = 1.75), consistent with previous studies on congenital heart defects. Forest et al observed a risk association between maternal tobacco exposure (both active and passive) during the periconceptional period and congenital heart defects 28 . Deng et al reported that periconceptional paternal smoking might increase the risk of certain subtypes of congenital heart defects 29 .…”

Section: Discussionmentioning

confidence: 99%

Propensity score analysis of the association between maternal exposure to second-hand tobacco smoke and birth defects in Northwestern China

et al. 2022

J Dev Orig Health Dis

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Previous studies have suggested that maternal active smoking can increase the risk of birth defects, but evidence on second-hand tobacco smoke (SHS) is limited. We aimed to assess the association between maternal exposure to SHS and birth defects in a Chinese population. The data were based on a large-scale cross-sectional survey conducted in Shaanxi Province, China. Considering the characteristics of survey design and the potential impact of confounding factors, we adopted propensity score matching (PSM) to match the SHS exposure group and the non-exposure group to attain a balance of the confounders between the two groups. Subsequently, conditional logistic regression was employed to estimate the effect of SHS exposure on birth defects. Furthermore, sensitivity analyses were conducted to verify the key findings. After nearest neighbor matching of PSM with a ratio of 2 and a caliper width of 0.03, there were 6,205 and 12,410 participants in the exposure and control group, respectively. Pregnant women exposed to SHS were estimated to be 58% more likely to have infants with overall birth defects (OR = 1.58, 95% CI: 1.30–1.91) and 75% more likely to have infants with circulatory system defects (OR = 1.75, 95% CI: 1.26–2.44). We also observed that the risk effect of overall birth defects had an increasing trend as the frequency of exposure increased. Additionally, sensitivity analyses suggested that our results had good robustness. These results indicate that maternal exposure to SHS likely increases the risk of overall birth defects, especially circulatory system defects, in Chinese offspring.

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“…Reduced blood mononuclear cells viability from the umbilical cord and an increase in ROS production have been reported in pregnant smokers compared to non-smokers (Rua Ede et al, 2014). Of note is recent evidence supporting the association between maternal tobacco exposure during the periconceptional period and congenital heart defects (Forest and Priest, 2016).…”

Section: Cigarette Smoke Agentsmentioning

confidence: 99%

Multiple exposures to environmental pollutants and oxidative stress: Is there a sex specific risk of developmental complications for fetuses?

Al-Gubory

2016

Birth Defects Research Pt C

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Medically assisted procreation significantly contributes to an increase in twin pregnancies. One of the major factors contributing to more twin births is the use of fertility treatments. Twin pregnancy is not without a risk for fetal organ development and the health outcome of new‐borns, children, and adults. Multiple pregnancies are associated with an increased risk of developmental complications, such as perinatal mortality, premature births, and low birth weight. Oxidative stress is involved in pregnancy disorders such as abortion, intrauterine growth retardation, and prenatal mortality. The link between oxidative stress and prenatal development, poorly perceived in the medical community, is a major problem in human reproductive medicine and health outcomes. The sex‐based considerations and analyses are also, often neglected in biomedical research. In addition, fetal sexual dimorphism in antioxidant pathways following intrauterine exposure to environmental pollutants has not been explored. This is an important area of research because sexually dimorphic antioxidant adaptive responses to early life exposure‐induced oxidative stress may have long‐term effects on offspring health outcome and increase the risk of non‐communicable diseases in men and women. This concept is useful, since it may open the avenue to develop antenatal antioxidant therapeutic strategies to developmental disorders and complications related to multiple pregnancies, and in association with acute or chronic environmental exposure. This article reviews the status of research, supporting data, possible pathogenic mechanisms, and future perspectives in the proposed area. Birth Defects Research (Part C) 108:351–364, 2016. © 2016 Wiley Periodicals, Inc.

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Intrauterine Tobacco Smoke Exposure and Congenital Heart Defects

Cited by 16 publications

References 38 publications

Developmental toxicity of e‐cigarette aerosols

Developmental toxicity of e‐cigarette aerosols

Propensity score analysis of the association between maternal exposure to second-hand tobacco smoke and birth defects in Northwestern China

Multiple exposures to environmental pollutants and oxidative stress: Is there a sex specific risk of developmental complications for fetuses?

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