Intrauterine subdural hemorrhage in a preterm neonate possibly associated with maternal low-molecular weight heparin treatment

Abstract

We report intrauterine subdural hemorrhage in a preterm infant delivered by cesarean section at 32 weeks following vaginal bleeding of a mother treated with low-molecular weight heparin (LMWH) for deep vein thrombosis. The subdural hematomas were partially calcified, proving antenatal occurrence. Maternal trauma during pregnancy, intrauterine infection, cerebral vascular malformation and congenital coagulopathy as known etiologies of subdural hemorrhage could be ruled out. Intrauterine subdural hemorrhage may be an exceptional complication of maternal LMWH treatment.

Intrauterine subdural hematoma associated with blunt maternal trauma: a case report

“…We found trauma as an etiological cause. Although it is stated in a publication that there is an intrauterine subdural hematoma after the use of LMWH, it is known that LMWH does not pass through the placenta [1,4].…”

Progressive Fetal Subdural Hematoma Associated With Maternal Vitamin K Deficiency: Prenatal Diagnosis and Neurologically Favorable Prognosis

“…We first performed a journal search in PubMed using the term “fetal subdural hemorrhage” and found 22 case reports in the English literature. Twelve reports referred to the causes, which were injury (2 cases), maternal anticoagulant drug intake (4 cases), maternal autoimmune thrombocytopenia (2 cases), fetal autoimmune thrombocytopenia (1 case), fetal hepatic dysfunction (1 case), and maternal vitamin K deficiency (2 cases) . Of the 2 cases with maternal vitamin K deficiency, 1 was by diarrhea due to Crohn disease, and the other was by vomiting due to an esophageal hernia .…”