Intrauterine Repair of Experimental Surgically Created Dysraphism

Heffez, Dan S.; Aryanpur, John; Rotellini, Nelson A. Cuello; Hutchins, Grover M.; Freeman, John M.

doi:10.1097/00006123-199306000-00021

Cited by 52 publications

(63 citation statements)

References 6 publications

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“…In the last years there has been diverse research in animals, like the one performed by Heffez et al 6,7 , in rats, Pedreira et al 8 . in rabbits, Meuli et al 9 in sheep, Pedreira et al 10 in ovine fetuses and Michjeda 11 in non human primates Macaca mulatta; creating intrauterine surgical models to reproduce different diseases and perform its correction.…”

Section: Discussionmentioning

confidence: 99%

Anesthetic management in intrauterine surgery to evaluate an experimental model of myelomeningocele in non human primates (Macaca mulatta)

et al. 2010

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Anesthetic management in intrauterine surgery to evaluate an experimental model of myelomeningocele in non human primates (Macaca mulatta) RESUMO Objetivo:Avaliar o manejo anestésico em cirurgia intra-uterina para induzir mielomeningocelo em primatas não humanos, Macaca mulatta. Métodos: Operaram-se um total de nove fetos in útero que foram submetidos à laminectomia em L5 e L6. As variáveis a estudar foram mortes maternas ou fetais, freqüência cardíaca e respiratória, pressão arterial, temperatura e saturação de oxigênio. Resultados: Não se apresentaram mortes maternas ou fetais, a temperatura se manteve abaixo dos 36°C, não tendo repercussões no bem-estar dos macacos. Conclusão: Não ocorreu nenhum óbito materno ou fetal, sendo que a única variável abaixo do normal foi a temperatura.

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Section: Discussionmentioning

confidence: 99%

Anesthetic management in intrauterine surgery to evaluate an experimental model of myelomeningocele in non human primates (Macaca mulatta)

et al. 2010

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“…Similarly, the oncofetal antigen CA 19-9 may diffuse to the maternal circulation through the amniotic fluid in open NTDs. Previous experimental studies in animals showed that exposure of the spinal cord to amniotic fluid contributes to local tissue inflammation and associated neurological sequelae [12,13]. Neuronal inflammation can also lead to elevated serum CA 19-9 levels [14].…”

Section: Www Journalsviamedicapl/ginekologia_polskamentioning

confidence: 99%

Diagnostic value of CA 19-9 in pregnancies complicated by spinal neural tube defects: a preliminary study

Tımur¹,

Tokmak

Yücel³

et al. 2016

Ginekol Pol

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Objectives: Various physiological and pathological conditions can induce significant variations in plasma concentrations of tumor markers, such as CA 19-9, which is present in the serum and amniotic fluid of pregnant women. Herein, we aimed to determine the clinical importance of maternal serum CA 19-9 levels in the diagnosis of neural tube defects (NTDs). Material and methods:A total of 100 women were included in this controlled cross-sectional study. Thirty-three patients whose pregnancies were complicated by isolated meningocele or meningomyelocele constituted the study group, whereas 33 normal, healthy pregnant women constituted the control group, and 34 age-and body mass index (BMI)-matched non-pregnant women were chosen for the validation group. Results:The mean maternal serum CA 19-9 levels were 17.2 ± 17.0 IU/mL, 7.1 ± 5.9 IU/mL, and 4.7 ± 3.6 IU/mL in the study, control, and validation groups, respectively (p < 0.001). ROC analyses showed that elevated CA 19-9 values may predict NTDs (p < 0.001). The cut-off value for CA 19-9 was found to be 9.6 IU/mL at 70% (51%-84%, 95% CI) sensitivity and 84% (74%-92%, 95% CI) specificity. Conclusions:CA 19-9 may be a promising noninvasive marker for NTDs. Further studies are needed to reveal the clinical applicability and diagnostic potential of maternal serum CA 19-9 levels in the identification of NTDs.

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“…7,8 In studies in animals, prenatal coverage of a spina bifidalike lesion preserved neurologic function and improved hindbrain herniation. [9][10][11][12][13] These data suggest a "two-hit" hypothesis in which the final neurologic deficit results from a combination of failure of neural-tube formation and spinal cord injury resulting from prolonged exposure of neural elements to the intrauterine environment.…”

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confidence: 92%