Intrauterine insemination + controlled ovarian hyperstimulation versus in vitro fertilisation in unexplained infertility: a systematic review and meta-analysis

Nandi, Anupa; Gangopadhyay, Raja; White, Davinia; El‐Toukhy, Tarek

doi:10.1007/s00404-021-06277-3

Cited by 12 publications

(7 citation statements)

References 35 publications

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“…For IVF, hormone stimulation is required, but it also allows for embryos to be stored for later use and for preimplantation genetic testing [2,24]. Success rates for pregnancies using IUI are estimated to be 5–25% whereas IVF success rates are typically 20–40% [25]. IVF can also be utilized for male individuals and female individuals if considering surrogacy.…”

Section: Fertilitymentioning

confidence: 99%

The modern landscape of fertility, pregnancy, and parenthood in people with cystic fibrosis

Jain,

Kazmerski,

Taylor-Cousar

2023

Current Opinion in Pulmonary Medicine

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Purpose of review With improved long-term survival and the expanding availability of cystic fibrosis transmembrane conductance regulator (CFTR) modulator therapies that treat the underlying genetic defect in cystic fibrosis, more people are interested in parenthood. Cystic fibrosis care centers and people with cystic fibrosis need more information to guide decisions related to parenting. Recent findings Here we present currently available data on fertility, pregnancy, and parenthood in the modern era of cystic fibrosis care. Fertility may be improving in female individuals with cystic fibrosis with the use of CFTR modulator therapies, and there is an associated increase in annual pregnancies. Infertility in male individuals with cystic fibrosis remains approximately 97–98% and is unchanged with CFTR modulators in those already born with cystic fibrosis. As more female individuals with cystic fibrosis experience pregnancy, questions remain about the impact of pregnancy on their health and that of their child. Fortunately, there are multiple routes to becoming a parent; however, more work is needed to understand the impact of pregnancy and parenthood in the context of CF as some previous data suggests potential challenges to the health of parents with cystic fibrosis. Summary We encourage cystic fibrosis care teams to have knowledge and resources available to support the reproductive goals of all individuals with cystic fibrosis.

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Section: Fertilitymentioning

confidence: 99%

The modern landscape of fertility, pregnancy, and parenthood in people with cystic fibrosis

Jain,

Kazmerski,

Taylor-Cousar

2023

Current Opinion in Pulmonary Medicine

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“…Although a systematic review included eight RCTs compared the efficacy of ovarian stimulation-IUI and IVF in couples with unexplained infertility. They concluded that regardless of previous treatment history, there was no difference in live birth rates if the female age was <38 but it also demonstrated that the live birth rate in women over 38 age was two times higher in IVF (20). An RCT compared the results of immediate IVF and two cycles of ovulation induction-IUI (oral agents and gonadotropin) in women aged 38-42 years with unexplained infertility (21).…”

Section: What Do the Guides Say?mentioning

confidence: 99%

Intrauterin Inseminasyon, IVF/ICSI

Çetin¹,

Özcan²

2022

Düzce Tıp Fakültesi Dergisi

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İnfertilite düzenli ilişkiye rağmen bir yılın sonunda gebe kalamama olarak tanımlanmaktadır. Bu aşamadan sonra başlayan değerlendirme süreci ile tedavi ihtiyacı ve tedavi seçeneği belirlenmektedir. Tedavi temel olarak over stimulasyonunu takiben zamanlı ilişki, intrauterin inseminasyon (IUI) ve in vitro fertilizasyon (IVF)/intrasitoplazmik sperm enjeksiyonunu (intracytoplasmic sperm injection, ICSI)’nu içermektedir. Burada uygun hasta ve uygun tedavi yönteminin seçilmesi kritiktir ve birçok faktöre bağlıdır. Anne yaşı ve infertilite etiyolojisi tedavi seçiminde ana belirteçtir. 38 yaş üzeri hastada hızla IVF/ICSI seçimi hakkında düşünmek ne kadar önemli ise çok düşük sperm parametreleri varlığında beklemeden yardımcı üreme tekniklerine geçmek de o kadar önemlidir. Uygun olmayan endikasyon tedavi en iyi şekilde bile yapılsa başarısız olacaktır. Uygun hasta seçimi ve tedavi aşamalarında hastaya yeterli süre verilmesi başarıyı artıracaktır. Sunulan makalede infertilite nedenlerine göre IUI ve IVF/ICSI hasta seçim kriterleri değerlendirilecektir. Burada hasta değerlendirmesinin hangi sıra ile yapılacağı ve basamaklı infertilite tedavisinde IVF/ICSI’ya giden yolda geçilmesi gereken basamaklar detaylı ve açıklayıcı olarak değerlendirilecektir.

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“…The most recent systematic review and meta‐analysis stated that ‘the wide field of definitions of unexplained infertility poses significant challenges in conducting research in this field’ 3 …”

Section: Introductionmentioning

confidence: 99%

The definition of unexplained infertility: A systematic review

Raperport,

Desai,

Qureshi

et al. 2023

BJOG

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BackgroundThere is no consensus on tests required to either diagnose unexplained infertility or use for research inclusion criteria. This leads to heterogeneity and bias affecting meta‐analysis and best practice advice.ObjectivesThis systematic review analyses the variability of inclusion criteria applied to couples with unexplained infertility. We propose standardised criteria for use both in future research studies and clinical diagnosis.Search strategyCINAHL and MEDLINE online databases were searched up to November 2022 for all published studies recruiting couples with unexplained infertility, available in full text in the English language.Data collection and analysisData were collected in an Excel spreadsheet. Results were analysed per category and methodology or reference range.Main resultsOf 375 relevant studies, only 258 defined their inclusion criteria. The most commonly applied inclusion criteria were semen analysis, tubal patency and assessment of ovulation in 220 (85%), 232 (90%), 205 (79.5%) respectively. Only 87/220 (39.5%) studies reporting semen analysis used the World Health Organization (WHO) limits. Tubal patency was accepted if bilateral in 145/232 (62.5%) and if unilateral in 24/232 (10.3%). Ovulation was assessed using mid‐luteal serum progesterone in 115/205 (56.1%) and by a history of regular cycles in 87/205 (42.4%). Other criteria, including uterine cavity assessment and hormone profile, were applied in less than 50% of included studies.ConclusionsThis review highlights the heterogeneity among studied populations with unexplained infertility. Development and application of internationally accepted criteria will improve the quality of research and future clinical care.

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Intrauterine insemination + controlled ovarian hyperstimulation versus in vitro fertilisation in unexplained infertility: a systematic review and meta-analysis

Cited by 12 publications

References 35 publications

The modern landscape of fertility, pregnancy, and parenthood in people with cystic fibrosis

The modern landscape of fertility, pregnancy, and parenthood in people with cystic fibrosis

Intrauterin Inseminasyon, IVF/ICSI

The definition of unexplained infertility: A systematic review

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