Intrauterine injection of HCG before embryo transfer: a parallel, double-blind randomized trial

Abdallah, Karim S.; Makhlouf, Ahmed; Badran, Esraa; Elnashar, Ihab; Al-Hussaini, Tarek K.; Farghaly, Tarek; Mohamed, Hazem S.; Mol, Ben Willem J.; Abdelmagied, Ahmed M.

doi:10.1016/j.rbmo.2021.06.011

Cited by 5 publications

(8 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Similar to our work, Assuit University conducted a study on 181 women who underwent IVF/ICSI with the intrauterine injection of 500 units of HCG in 0.1 ml culture media 4 minutes prior to ET (whether fresh or vitrified-warmed embryo). HCG intrauterine injection before embryo transfer did not increase live birth rates in women having IVF, with clinical pregnancy rates in the study and control groups being 24 percent versus 19 percent, respectively (13) .…”

Section: Discussionmentioning

confidence: 67%

Value of Intrauterine Injection of HCG (Human Chorionic Gonadotropin) before Fresh Embryo Transfer on Clinical Pregnancy Rate in Women with Previous Failed One or Two ICSI (Intra Cytoplasmic Sperm Injection) Trials

Atef

Farag²,

El-Nassery

et al. 2022

The Egyptian Journal of Hospital Medicine

View full text Add to dashboard Cite

The human endometrium is a complex, multicellular tissue that is regulated by steroid hormones (estrogens, progesterone, androgens, and glucocorticoids) and has different characteristics in the various phases of the menstrual cycle. HCG plays a major role in endometrial receptivity via modulation of the production of various cytokines and chemokines. Aim of the Work:The study aimed to show the effect of intrauterine injection of Human Chorionic Gonadotropin (HCG) on the day of ovum pickup in patients with a history of one or two failed Intra Cytoplasmic Sperm injections (ICSI). Patients, and Methods: A sample of 110 patients was obtained, half of them were candidates for intrauterine injection of 500 units of HCG immediately after ovum retrieval during the mock, while the other half were controls. All patients underwent controlled ovarian stimulation using the long protocol. The study was conducted at the Assisted reproduction unit of

show abstract

Section: Discussionmentioning

confidence: 67%

Value of Intrauterine Injection of HCG (Human Chorionic Gonadotropin) before Fresh Embryo Transfer on Clinical Pregnancy Rate in Women with Previous Failed One or Two ICSI (Intra Cytoplasmic Sperm Injection) Trials

Atef

Farag²,

El-Nassery

et al. 2022

The Egyptian Journal of Hospital Medicine

View full text Add to dashboard Cite

show abstract

“…Fifty-four papers were assessed for eligibility. Eighteen RCTs were included in the qualitative and quantitative analysis [ 10 , 11 , 15 , 16 , 17 , 18 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 37 , 38 , 39 , 40 , 41 ]. The baseline characteristics of the studies included are reported in Table 1 .…”

Section: Resultsmentioning

confidence: 99%

“…The most recent Cochrane review includes 17 RCTs, 6 of which are conference abstracts, and concluded that women undergoing cleavage-stage transfer might benefit from intrauterine hCG [ 20 ]. Since the publication of the latter paper, another seven RCTs have been published [ 22 , 23 , 24 , 25 , 26 , 27 , 28 ]. More recently, a comprehensive meta-analysis of different interventions, including intrauterine hCG during embryo transfer, concluded that intrauterine hCG could significantly increase the clinical pregnancy rate [ 29 ].…”

Section: Introductionmentioning

confidence: 99%

“…Given the relevance of the topic and recent results [ 25 , 26 , 28 ], it is pertinent to update previous data. Consequently, we conducted a review and meta-analysis to assess IVF outcomes by comparing couples who underwent intrauterine hCG injection transfer versus those who underwent embryo transfer with intrauterine injection, placebo, or without any additional intervention.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Does Intrauterine Injection of hCG Improve IVF Outcome? A Systematic Review and a Meta-Analysis

Conforti

Longobardi

Carbone

et al. 2022

IJMS

View full text Add to dashboard Cite

Various interventions have been proposed to improve embryo implantation in IVF. Among these, intrauterine injections of human chorionic gonadotropin seem to have promising results. Consequently, we conducted a review and meta-analysis to assess IVF outcomes by comparing couples who underwent intrauterine hCG injection transfer versus those who underwent embryo transfer with intrauterine injection of placebo, or without any additional intervention. The primary outcome was the clinical pregnancy rate. Secondary outcomes were the implantation rate, miscarriage rate, and live birth rate. A meta-analysis was conducted using the random effects model, while bias within studies was detected using the Cochrane risk of bias tool. Ectopic pregnancies and stillbirths were also assessed. The clinical pregnancy (RR 1.38, 95% CI 1.17–1.62, p < 0.0001) and implantation rate (RR 1.40, 95% CI 1.12–1.75, p = 0.003) were significantly higher in women who underwent hCG injection than in the control group. These significant effects persisted only in women who underwent cleavage-stage embryo transfer. No significant differences between groups were observed in the other secondary outcomes. In conclusion, our systematic review and meta-analysis demonstrate that intrauterine injection of hCG could be a valuable approach in women who undergo cleavage-stage embryo transfer. Given the lack of data about the live birth rate, caution should be exercised in interpreting these data.

show abstract

“…One study showed that cytokines related to hCG after 4 weeks of pregnancy were significantly altered in women with spontaneous miscarriage ( 19 ). Thus, lack of hCG secretion may be relevant to EPL ( 20 ) Meanwhile, many researchers have explored the clinical effect of hCG intrauterine infusion in assisted reproduction patients, with inconsistent results ( 21 – 24 ). However, the pathophysiological mechanism linking hCG to EPL has not yet been established.…”

Section: Discussionmentioning

confidence: 99%

Independent value of serum β-human chorionic gonadotropin in predicting early pregnancy loss risks in IVF/ICSI cycles

et al. 2022

View full text Add to dashboard Cite

BackgroundEarly pregnancy loss (EPL) is the most prevalent complication, particularly in couples undergoing assisted reproductive technology treatment. The present study aimed to determine whether the serum β-human chorionic gonadotropin (β-hCG) level after 14 days of embryo transfer, either alone or in conjunction with other parameters in IVF/ICSI cycles, could be used to predict subsequent EPL.MethodsThis was a retrospective cohort study of all couples who received clinical pregnancy and underwent fresh IVF/ICSI cycles at a single large reproductive medical center between January 2013 and June 2020. The research involved a total of 6600 cycles. For risk variables, we conducted the least absolute shrinkage and selection operator (LASSO) analysis, and for risk scoring, we used logistic regression coefficients. To analyze relevant risk factors for EPL, univariate and multivariate logistic regression analyses were employed. Areas under the curve (AUC) were determined and compared between β-hCG and other factors using receiver operating characteristic (ROC) curves.Resultsβ-hCG level was considerably lower in women who had EPL than in those who were ongoing pregnancy (564.03 ± 838.16 vs 1139.04 ± 1048.72 IU/L, p< 0.001). Univariable and multivariable logistic regression revealed that β-hCG levels were significantly correlated with the probability of EPL, independent of other risk factors. More importantly, the β-hCG level could independently predict the occurrence of EPL and was comparable to the model that combined other risk factors. The optimal serum β-hCG cut-off value for predicting EPL was 542.45 IU/L.ConclusionsOur results suggest that the serum β-hCG level has a strong independent predictive value for EPL occurrence in fresh IVF/ICSI cycles.

show abstract

Intrauterine injection of HCG before embryo transfer: a parallel, double-blind randomized trial

Cited by 5 publications

References 23 publications

Value of Intrauterine Injection of HCG (Human Chorionic Gonadotropin) before Fresh Embryo Transfer on Clinical Pregnancy Rate in Women with Previous Failed One or Two ICSI (Intra Cytoplasmic Sperm Injection) Trials

Value of Intrauterine Injection of HCG (Human Chorionic Gonadotropin) before Fresh Embryo Transfer on Clinical Pregnancy Rate in Women with Previous Failed One or Two ICSI (Intra Cytoplasmic Sperm Injection) Trials

Does Intrauterine Injection of hCG Improve IVF Outcome? A Systematic Review and a Meta-Analysis

Independent value of serum β-human chorionic gonadotropin in predicting early pregnancy loss risks in IVF/ICSI cycles

Contact Info

Product

Resources

About