Intrauterine infection, magnesium sulfate exposure and cerebral palsy in infants born between 26 and 30 weeks of gestation

Matsuda, Yoshihisa; Kouno, Satoshi; Hiroyama, Yoshifumi; Kuraya, Kazue; Kamitomo, Masato; Ibara, Satoshi; Hatae, Masayuki

doi:10.1016/s0301-2115(99)00256-0

Cited by 42 publications

(22 citation statements)

References 14 publications

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“…Two of these studies were replaced by new reports [Gray et al, 2000;Yoon et al, 2000] published in the year 2000, which provided updated information on a group of patients that had been previously reported. Two new studies [Matsuda et al, 2000;Ng et al, 2000] were also identified and added to the meta-analysis. Another new study evaluating the association between chorioamnionitis and cPVL involved both preterm and term infants [Bauder et al, 2000], and thus had to be examined separately.…”

Section: Premature Infantsmentioning

confidence: 99%

“…Eight studies evaluated the association between histologic chorioamnionitis and cerebral palsy in premature infants [Yoon et al, 1997;O'Shea et al, 1998;Redline et al, 1998;Grether and Nelson, 2000;Jacobsson et al, 2000;Yoon et al, 2000;Matsuda et al, 2000;Ng et al, 2000] with only two reporting a significant association [Jacobsson et al, 2000;Yoon et al, 2000]. These studies were found to be heterogeneous (Table 1).…”

Section: Premature Infantsmentioning

confidence: 99%

“…When the baseline prevalence of clinical chorioamnionitis was compared to the mean study year, there was a trend towards higher rates of diagnosis in later years (Spearman's rank P ϭ 0.09). Seven studies of clinical chorioamnionitis in premature infants reported relative risks controlled for gestational age [O'Shea et al, 1998;Spinillo et al, 1998;Wilson-Costello et al, 1998;Baud et al, 1999;Grether and Nelson, 2000;Jacobsson et al, 2000;Matsuda et al, 2000]. The summary relative risk calculated from adjusted estimates was smaller than *PROM ϭ premature rupture of membranes; UT ϭ uterine tenderness; M tach ϭ maternal tachycardia; F tach ϭ fetal tachycardia; WBC ϭ maternal leukocytosis CRP ϭ elevated C-reactive protein; None ϭ no definition provided by the paper †Baseline prevalence of clinical chorioamnionitis; in case-control studies, estimated from prevalence of clinical chorioamnionitis in controls §Abstracts available only **Previously published study defined chorioamnionitis as T Ͼ 37.5 plus either clinical, histological, or microbiologic evidence of infection that derived from unadjusted estimates (RR 2.0 vs. 2.4, P ϭ 0.08).…”

Section: Stratified Analysis In Preterm Infantsmentioning

confidence: 99%

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Systematic review of chorioamnionitis and cerebral palsy

2002

Ment. Retard. Dev. Disabil. Res. Rev.

213

126

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In a recent meta-analysis evaluating the relationship between chorioamnionitis and cerebral palsy, we found that chorioamnionitis is a risk factor for both cerebral palsy and cystic periventricular leukomalacia (cPVL). The current paper extends the meta-analysis by including studies published in the year 2000, and by further evaluating the causes of heterogeneity among individual study results. Using a random effects model, clinical chorioamnionitis was significantly associated with both cerebral palsy (RR 1.9, 95% CI 1.5-2.5) and cPVL (RR 2.6, 95% CI 1.7-3.9). Sources of heterogeneity included widely varying practices in the diagnosis of clinical chorioamnionitis, different gestational age characteristics, and varying study year. We conclude that based on the available literature, chorioamnionitis is a risk factor for both cerebral palsy and cPVL.

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Section: Premature Infantsmentioning

confidence: 99%

Section: Premature Infantsmentioning

confidence: 99%

Section: Stratified Analysis In Preterm Infantsmentioning

confidence: 99%

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Systematic review of chorioamnionitis and cerebral palsy

2002

Ment. Retard. Dev. Disabil. Res. Rev.

213

126

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“…Cerebral palsy was defined as a chronic disability of central nervous system origin, characterized by aberrant control of movement or posture, appearing early in life and not being the result of progressive disease. A child must be at least 2 years of age at the most recent diagnosis to be considered a confirmed case [18]. A poor perinatal outcome was defined when either perinatal mortality or cerebral palsy was observed.…”

Section: Methodsmentioning

confidence: 99%

Fetal and Neonatal Outcomes in Twin Oligohydramnios-Polyhydramnios Sequence Including Cerebral Palsy

Matsuda¹,

Kouno²

2002

Fetal Diagn Ther

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Objective: The purpose of this study was to review consecutive pregnancies complicated by twin oligohydramnios-polyhydramnios sequence (TOPS) and to clarify the probable factors influencing the perinatal outcomes. Methods: Twenty-five pregnancies with a diagnosis of TOPS were treated with and without amniocentesis. A poor perinatal outcome was defined when either perinatal mortality or cerebral palsy was observed. Results: The mean gestational age at the time of diagnosis and of delivery was 27.8 (range 21–34) and 30.7 (range 23–35) weeks, respectively. Tocolytic therapy and therapeutic amniocentesis were done in 16 (64%) and 13 (52%) cases. Hydrops fetalis was present in 10 cases. The survival rate was 72%, and cerebral palsy was diagnosed in 8 of 36 infants (22%). The poor prognostic factors were gestational age at delivery (<30 weeks) and presence of symptomatic preterm labor and hydrops fetalis. Therapeutic amniocentesis did not influence the perinatal outcome. Conclusions: In this observational study, the long-term as well as the short-term perinatal outcome of pregnancy with TOPS seems to be poor. In addition, therapeutic amniocentesis in TOPS does not appear to affect fetal and neonatal outcomes.

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“…Many authors recommended the Magnesium Sulphate (MgSO4) infusion for prevention of CP in preterm infants delivered before 34 gestational weeks` [5] .…”

Section: Introductionmentioning

confidence: 99%

Antenatal Magnesium Sulphate (Mgso4) for Fetal NeuroProtection Prior to Preterm Labor: Mini-Review

2017

ARC Journal of Gynecology and Obstetrics

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Intrauterine infection, magnesium sulfate exposure and cerebral palsy in infants born between 26 and 30 weeks of gestation

Cited by 42 publications

References 14 publications

Systematic review of chorioamnionitis and cerebral palsy

Systematic review of chorioamnionitis and cerebral palsy

Fetal and Neonatal Outcomes in Twin Oligohydramnios-Polyhydramnios Sequence Including Cerebral Palsy

Antenatal Magnesium Sulphate (Mgso4) for Fetal NeuroProtection Prior to Preterm Labor: Mini-Review

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