Intrauterine Herpes Simplex Virus Infection Presenting as a Zosteriform Eruption in a Newborn

Drumm, Caitlin; Caufield, Maura; DeKlotz, Cynthia M. C.; Pasieka, Helena B.; Abubakar, Kabir

doi:10.1055/s-0038-1635100

Cited by 13 publications

(6 citation statements)

References 8 publications

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“…We also identified 16 additional cases that met our criteria through the literature search. [5][6][7][8][9][10][11][12][13][14][15][16][17][18][19] Among the 22 cases, four (18%) occurred in twin pregnancies.…”

Section: Re Sultsmentioning

confidence: 99%

Heterogeneous cutaneous findings associated with intrauterine HSV infection: A case series and literature review

Pithadia

Kerns

Golden

et al. 2021

Pediatric Dermatology

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Section: Re Sultsmentioning

confidence: 99%

Heterogeneous cutaneous findings associated with intrauterine HSV infection: A case series and literature review

Pithadia

Kerns

Golden

et al. 2021

Pediatric Dermatology

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“…There is increasing awareness of the importance of skin infection disease caused by HSV infection. Several of emerging cases were found continuously in recent years [2,3], which indicated an upward trend in HSV incidence. Extensive evidence proved that HSV viruses could typically cause severe afflictions, mainly because of the generation of genital lesions and severe infections like life-threatening encephalitis and disseminated infections in neonates [4][5][6].…”

Section: Introductionmentioning

confidence: 99%

Antiviral mechanism of carvacrol on HSV-2 infectivity through inhibition of RIP3-mediated programmed cell necrosis pathway and ubiquitin-proteasome system in BSC-1 cells

Wang

et al. 2020

BMC Infect Dis

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Background Carvacrol, as the major components of aromatic plants used for treating human skin diseases including origanum, Satureja, thymus, and coridothymus species, presented a kind of antiviral activity. To explore the mechanisms of carvacrol against herpes simplex virus (HSV) in vitro. Method The BSC-1 cells model of HSV infection was established, and from the two aspects of viral replication level and cell death pathway, the antiviral effects of carvacrol on HSV infected cells were also evaluated by plaque assay under the three modes including prevention, treatment, and direct inactivation. Results In the three ways, the half-maximal effective concentration (EC50) of 2% true carvacrol solution on HSV-2 infected cells were severally 0.43, 0.19 and 0.51 mmol/L, and the corresponding therapeutic index (TI) were 4.02, 9.11 and 3.39, respectively. It’s the opposite of the increased levels caused by HSV-2 infection, that both the expressions at the transcription genes and protein levels of virus own replication key factors (including ICP4, ICP27, VP16, gB, and UL30) and cytokines (including RIP3, TNF-α, and MLKL) of infected cells treated with carvacrol were dose-dependently inhibited. Besides, HSV-2 infection can cause the decrease of intracellular protein ubiquitination level, and carvacrol can reverse the ubiquitination decrease level caused by HSV-2 infection. Conclusion Carvacrol exhibits significant antiviral activity by inhibiting the HSV-2 proliferation process and HSV-2-induced TNF-α increasing levels, decreasing RIP3 and MLKL protein expressions through the intracellular RIP3-mediated programmed cell necrosis pathway. In addition, carvacrol also may exhibit anti-HSV-2 activity by reversing the ubiquitination decrease level caused by HSV-2 infection on the ubiquitin-proteasome system, which provides insights into the molecular mechanism.

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“…This situation makes the diagnosis even more challenging as newborns often present with non-specific and subtle clinical findings, making a timely and accurate diagnosis of infection critical, particularly as disseminated neonatal HSV is associated with almost 30% mortality. 10 11 …”

Section: Discussionmentioning

confidence: 99%

Prolonged fever and hyperferritinaemia: a puzzling diagnosis of neonatal herpes simplex virus infection during COVID-19 pandemic

et al. 2021

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Neonatal herpes simplex virus (HSV) infection is rare, with an estimated incidence of 3.58 per 100 000 live births in the UK and should be suspected in any newborn with fever and bacterial culture-negative sepsis. We describe a case of a previously well full-term male neonate who presented with persistent fever and elevated ferritin level that was carried out during the era of the COVID-19 pandemic as part of SARS-CoV-2 panel investigations. Despite the initial negative HSV serology, HSV-1 PCR from a scalp lesion returned positive. He made a full recovery after acyclovir therapy. This case highlights the importance of maintaining a high clinical index of suspicion of HSV infection in any febrile neonate even with absence of maternal history and negative serology, particularly if associated with hyperferritinaemia. We also address the challenge of interpreting inflammatory biomarkers’ results for SARS-CoV-2 infection in neonates.

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Intrauterine Herpes Simplex Virus Infection Presenting as a Zosteriform Eruption in a Newborn

Cited by 13 publications

References 8 publications

Heterogeneous cutaneous findings associated with intrauterine HSV infection: A case series and literature review

Heterogeneous cutaneous findings associated with intrauterine HSV infection: A case series and literature review

Antiviral mechanism of carvacrol on HSV-2 infectivity through inhibition of RIP3-mediated programmed cell necrosis pathway and ubiquitin-proteasome system in BSC-1 cells

Prolonged fever and hyperferritinaemia: a puzzling diagnosis of neonatal herpes simplex virus infection during COVID-19 pandemic

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