Intrauterine growth retardation (IUGR) in pre-term infants

Abstract

Intrauterine growth retardation (IUGR) in pre-term infants 13(1985) 171

Occurrence, predictive factors and associated morbidity of broncho-pulmonary dysplasia in a preterm birth cohort

“…However, the present data suggest that restricted intrauterine growth (IUGR) deserves further investigation as a possible risk factor of BPD. The unfavourable effects of IUGR on neonatal wellbeing [20,21] and on the developmental prospects [22,24] of preterm infants have also been recently established.…”

Neurodevelopmental screening of in utero growth-retarded prematurely born children before school age

“…1977, two cohorts of prematurely born children of the same age (N = 209, gestational age -< 36 weeks) were formed to assess the effects of IUGR on morbidity, mortality, growth and neurological development. The children had been born and were treated in Kuopio University Central Hospital, which is a regional centre for neonatal intensive care in the province of Kuopio, in Finland, Early morbidity and mortality in relation to prematurity and intrauterine growth status in these cohorts has previously been reported [13]. Members of the cohorts were prospectively followed-up in the neonatal out-patient clinic.…”

“…"Normal" values for growth parameters were defined as values within 2 SD of the mean for the gestational age. "Low" was defined as a value more than 2 SD below the expected mean for the gestational age [13]. 2) Freedom from any malformation or major neurological handicaps (cerebral palsy).…”

“…Asymmetrical IUGR, characterized by a normal birth length but a low ponderal index (PI) [25] and/or a low birth weight for the gestational age, had previously been found to be the commonest intrauterine growth disorder in these cohorts [13]. Twenty-three prematurely born children with asymmetrical IUGR were allocated to the premature IUGR study group, representing 62% of alL~4he survivors with asymmetrical IUGR originally detecte~l~ig the two cohorts at birth.…”

“…malformations, often have unfavourable prognoses. Even if cases of malformation are excluded, premature infants with IUGR have a worse overall outlook, with higher morbidity and mortality and an increased incidence of severe neurological handicap than appropriate for gestational age (AGA) premature infants of corresponding gestational ages [13,16,27].…”