Intrauterine Growth Retardation in the Rat Leads to Reduced Proliferation and Increased Apoptosis of the B-Cell

Simmons, Rebecca A.; Templeton, Lori J.; Niu, Hongshun

doi:10.1203/00006450-199904020-00374

Cited by 2 publications

(1 citation statement)

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“…More specifically, type 2 diabetes mellitus (T2DM) is associated with genetic predisposition and environmental factors, such as obesity and diet (7). During pregnancy and the early stages of diabetes, compensatory proliferation of pancreatic b cells occurs in response to changes in blood glucose (8,9). Glucose itself is able to stimulate b cell replication (10), and several lines of evidence indicate that the terminally differentiated pancreatic b cells retain significantly proliferative capacity in vivo (11,12).…”

Section: Introductionmentioning

confidence: 99%

SNAPIN Regulates Cell Cycle Progression to Promote Pancreatic β Cell Growth

Jiang

Kuang

et al. 2021

Front. Endocrinol.

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In diabetes mellitus, death of β cell in the pancreas occurs throughout the development of the disease, with loss of insulin production. The maintenance of β cell number is essential to maintaining normoglycemia. SNAPIN has been found to regulate insulin secretion, but whether it induces β cell proliferation remains to be elucidated. This study aimed to explore the physiological roles of SNAPIN in β cell proliferation. SNAPIN expression increases with the age of mice and SNAPIN is down-regulated in diabetes. KEGG pathway and GO analysis showed that SNAPIN- interacting proteins were enriched in cell cycle regulation. B cell cycle was arrested in the S phase, and cell proliferation was inhibited after SNAPIN knockdown. The expression of CDK2, CDK4 and CCND1 proteins in the S phase of the cell cycle were reduced after SNAPIN knockdown, whereas they were increased after overexpression of SNAPIN. In addition, insulin protein and mRNA levels also increased or decreased after SNAPIN knockdown or overexpression, respectively. Conclusions: Our data indicate that SNAPIN mediates β cells proliferation and insulin secretion, and provide evidences that SNAPIN might be a pharmacotherapeutic target for diabetes mellitus.

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Section: Introductionmentioning

confidence: 99%

SNAPIN Regulates Cell Cycle Progression to Promote Pancreatic β Cell Growth

Jiang

Kuang

et al. 2021

Front. Endocrinol.

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Neonatal Exendin-4 Prevents the Development of Diabetes in the Intrauterine Growth Retarded Rat

Stoffers

Desai²,

León³

et al. 2003

Diabetes

248

207

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Uteroplacental insufficiency resulting in fetal growth retardation is a common complication of pregnancy and a significant cause of perinatal morbidity and mortality. Epidemiological studies show an increased incidence of type 2 diabetes in humans who were growth retarded at birth. The mechanisms by which an abnormal intrauterine milieu leads to the development of diabetes in adulthood are not known. Therefore, a rat model of uteroplacental insufficiency was developed; intrauterine growth-retarded (IUGR) rats develop diabetes with a phenotype similar to that observed in the human with type 2 diabetes. We show here that administration of a pancreatic ␤-cell trophic factor, exendin-4 (Ex-4), during the prediabetic neonatal period dramatically prevents the development of diabetes in this model. This occurs because neonatal Ex-4 prevents the progressive reduction in insulin-producing ␤-cell mass that is observed in IUGR rats over time. Expression of PDX, a critical regulator of pancreas development and islet differentiation, is restored to normal levels, and islet ␤-cell proliferation rates are normalized by the neonatal Ex-4 treatment. These results indicate that exposure to Ex-4 in the newborn period reverses the adverse consequences of fetal programming and prevents the development of diabetes in adulthood. Diabetes 52: 734 -740, 2003

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Intrauterine Growth Retardation in the Rat Leads to Reduced Proliferation and Increased Apoptosis of the B-Cell

Cited by 2 publications

References 0 publications

SNAPIN Regulates Cell Cycle Progression to Promote Pancreatic β Cell Growth

SNAPIN Regulates Cell Cycle Progression to Promote Pancreatic β Cell Growth

Neonatal Exendin-4 Prevents the Development of Diabetes in the Intrauterine Growth Retarded Rat

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