Intrauterine Growth Restriction following Ligation of the Uterine Arteries Leads to More Severe Glomerulosclerosis after Mesangioproliferative Glomerulonephritis in the Offspring

Plank, Christian; Nüsken, Kai-Dietrich; Menendez-Castro, Carlos; Hartner, Andrea; Östreicher, Iris; Amann, Kerstin; Baumann, Pia; Peters, Harm; Rascher, Wolfgang; Dötsch, Jörg

doi:10.1159/000319045

Cited by 37 publications

(39 citation statements)

References 72 publications

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“…Bax can induce cell apoptosis and inactive Bcl-2 by forming heterogenous dimers that coalesce with Bcl-2. [19][20][21] Pham et al suggested that Bcl-2 expression was significantly down-regulated and Bax expression was significantly up-regulated in FGR models, 22,23 which was similar to our results in humans. Results from a previous animal study suggested that the decreased number of nephrons in FGR was not only related to cell apoptosis, but also to the changes in the renin-angiotensinogen system (RAS).…”

Section: Discussionsupporting

confidence: 91%

Effects of a restricted fetal growth environment on human kidney morphology, cell apoptosis and gene expression

Wang

Zhang

et al. 2014

J Renin Angiotensin Aldosterone Syst

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Objective: Kidney development is key to the onset of hypertension and cardiovascular diseases in adults, and in the fetal stage will be impaired by a lack of nutrients in utero in animal models. However, few human studies have been performed. Methods: Kidney samples from fetuses in a fetal growth restriction (FGR) environment were collected and the morphological characteristics were observed. Potentially molecular mechanisms were explored by analyzing apoptosis and kidney-development related gene expression. Results: The results indicated that no malformations were observed in the kidney samples of the FGR group, but the mean kidney weight and volume were significantly decreased. Moreover, the ratio of apoptotic cells and Bax-positive cells was increased and the ratio of Bcl-2-positive cells was decreased in the FGR group, indicating potential apoptosis induction under an in utero FGR environment. Finally, aberrant expression of renin and angiotensinogen indicated potential kidney functional abnormalities in the FGR group. Conclusions: Our study suggested increased apoptosis and decreased renin and angiotensinogen expression during human kidney development in an FGR environment. The current results will be helpful to further explore the molecular mechanism of FGR and facilitate future studies of hypertension and cardiovascular diseases and the establishment of preventive methods.

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Section: Discussionsupporting

confidence: 91%

Effects of a restricted fetal growth environment on human kidney morphology, cell apoptosis and gene expression

Wang

Zhang

et al. 2014

J Renin Angiotensin Aldosterone Syst

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“…Interestingly, human and animal studies demonstrate a programming of inflammatory response subsequent to IUGR [18,19]. In line with these observations, Plank et al highlighted a predisposition of former IUGR animals for renal fibrosis and inflammation with a strikingly upregulation of inflammatory and profibrotic marker [Interleukin-6 (IL-6), tumor necrosis factor α (TNF-α), transforming growth factor β (TGF-β)] and of ECM components (collagen I and collagen IV) [20]. It is intriguing though that pulmonary inflammatory response as a link between perturbed ECM and IUGR has not been addressed so far.…”

Section: Introductionmentioning

confidence: 90%

Developmental regulation of inflammatory cytokine-mediated Stat3 signaling: the missing link between intrauterine growth restriction and pulmonary dysfunction?

et al. 2012

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Intrauterine growth restriction (IUGR) is a risk factor for impairment of lung function in adolescence and adulthood. Inflammatory and proliferative processes linking IUGR and perturbed extracellular matrix (ECM) as an underlying mechanism have not been addressed so far. Therefore, in this study, we aimed to investigate the developmental regulation of inflammatory and profibrotic processes in the lung subsequent to IUGR. IUGR was induced in rats by isocaloric protein restriction during gestation. Lung function was assessed with direct plethysmography at postnatal day (P) 28 and P70. Lungs were obtained at P1, P42, and P70 for assessment of mRNA, protein expression, immunohistochemistry, and gelatinolytic activity. Both respiratory system resistance and compliance were impaired subsequent to IUGR at P28 and this impairment was even more pronounced at P70. In line with these results, the expression of ECM components and metabolizing enzymes was deregulated. The deposition of collagen was increased at P70. In addition, the expression of inflammatory cytokines and both the activity and the expression of target genes of Stat3 signaling were dynamically regulated, with unaltered or decreased expression at P1 and significantly increased expression art P70. Taken together, these data give evidence for an age-dependent impairment of lung function as a result of a developmentally regulated increase in inflammatory and profibrotic processes subsequent to IUGR.

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“…[19][20][21][22][23] This model also induces brain injuries related to intrauterine growth restriction (IUGR) in pups, and also fetal deaths. [21][22][23] It is still used today, especially to study these brain injuries. [21][22][23][24] For this study, 32 female rats were anaesthetised on day 16 of pregnancy by intraperitoneal injection of 2% xylazine (Rompum; Bayer, Puteaux, France) and ketamine (Imalgène; Rhô ne Mérieux, Lyon, France).…”

Section: Animal Modelmentioning

confidence: 99%

SPIO‐enhanced magnetic resonance imaging study of placental perfusion in a rat model of intrauterine growth restriction

Deloison

Siauve

Aimot

et al. 2012

BJOG

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Objective To assess placental perfusion with magnetic resonance imaging (MRI) and superparamagnetic iron oxide (SPIO) in a rat model of intrauterine growth restriction (IUGR).Design Experimental animal study.Setting The study complied with US National Institutes of Health recommendations for animal care.Population Thirty-two rats at day 16 of gestation underwent surgical ligation of the left uterine vessel to induce IUGR.Methods Eighteen rats were examined by MRI 3 days later, after bolus injection of ferucarbotran.Main outcome measure Signal intensities were measured in the maternal left ventricle and in the placentas of the two horns. Quantitative microcirculation parameters were calculated and compared between the placentas of the two horns.Results Fifty-four kinetic curves of placental perfusion were obtained in 11 rats. The mean placental blood flow was significantly lower in the ligated horns than in the normal horns (108.1 versus 159.4 ml/minute/100 ml, p = 0.0004). The mean fractional volume of the maternal vascular placental compartment did not differ significantly between the pathological (42.8%) and normal placentas (39.2%).Conclusions Placental perfusion, including changes during experimental IUGR, can be measured in rats by using MRI with SPIO. These findings could have implications for human studies of placental microcirculation and for the management of disorders related to placental dysfunction.

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Intrauterine Growth Restriction following Ligation of the Uterine Arteries Leads to More Severe Glomerulosclerosis after Mesangioproliferative Glomerulonephritis in the Offspring

Cited by 37 publications

References 72 publications

Effects of a restricted fetal growth environment on human kidney morphology, cell apoptosis and gene expression

Effects of a restricted fetal growth environment on human kidney morphology, cell apoptosis and gene expression

Developmental regulation of inflammatory cytokine-mediated Stat3 signaling: the missing link between intrauterine growth restriction and pulmonary dysfunction?

SPIO‐enhanced magnetic resonance imaging study of placental perfusion in a rat model of intrauterine growth restriction

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