Intrauterine exposure to copper IUDs and prenatal development in the rat

Barlow, Susan; Knight, A. F.; House, Ivan

doi:10.1530/jrf.0.0620123

Cited by 5 publications

(5 citation statements)

References 21 publications

(17 reference statements)

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“…Copper levels in the rat maternal liver were not elevated, but the copper released from the intrauterine copper wire did penetrate into the fetus, as has also been demonstrated in the rab bit [19]. Fetal brain copper levels were increased by 65% and fetal liver levels by more than 100% in neonates who were exposed to copper as compared with the low levels in animals with a steel wire, or untreated control groups [ 12].…”

Section: Discussionmentioning

confidence: 52%

“…It should be noted that in the staining control procedure, the copper concentration was about 10 pg and has been unequivocally diagnosed or determined in the control animals. Therefore it is evident that a 40-pg concentra tion as found in the animals or 70 pg in the human cases as shown above [12,21] would result in copper deposits in the exposed organs or tissue which are definitely detectable by this staining method.…”

Section: Discussionmentioning

confidence: 78%

“…Although the copper ions released from intrauterine copper wire are absorbed systemically in the rat [11], the study of Barlow et al [12] demonstrates that the amount is insufficient to elevate copper levels in the maternal blood and had no teratogenic or growth-retarding effect. This finding is similar in women using copper-bearing IUDs [6, [13][14][15] as found also in our study.…”

Section: Discussionmentioning

confidence: 99%

“…This can be compared with 25-40 pg coppcr/day released from IUDs in a single uterine horn of rats weighing 0.5 g at the start of pregnancy, despite the fact that the exposure of rat conceptuses to copper was much greater than that found in women [ 12], no teratogenic effects were observed. It should be noted that in the staining control procedure, the copper concentration was about 10 pg and has been unequivocally diagnosed or determined in the control animals.…”

Section: Discussionmentioning

confidence: 99%

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Development of Human Embryos in the Presence of a Copper Intrauterine Device

Бараш¹,

Shoham²,

Borenstein³

et al. 1990

Gynecol Obstet Invest

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This study was designed to examine the teratogenic potential of copper releasing intrauterine contraceptive devices on the developing embryo. The tissues and organs of 11 whole embryos between 7 and 12 weeks of gestation were histologically examined for copper absorption after exposure to a copper intrauterine device in utero. The findings were not significantly different when compared with a control group of 7 embryos. No malformation or copper aggregates were observed in the various organs and placentas. The observations in this small sample would suggest that the copper-releasing intrauterine device has no deleterious effects on fetal development. The question remains whether malformations reported in some cases are associated with copper deposits in the tissues or with free copper ions in the fetal circulation. The implications are discussed.

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Section: Discussionmentioning

confidence: 52%

Section: Discussionmentioning

confidence: 78%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Development of Human Embryos in the Presence of a Copper Intrauterine Device

Бараш¹,

Shoham²,

Borenstein³

et al. 1990

Gynecol Obstet Invest

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show abstract

“…As early as 1981, Barlow, et al found that IUDs in rodents would release embryotoxic agents which could threat embryo development, malformation in fetal brain and liver [4,16,17]. When intrauterine pregnancy is detected in a patient with IUD, evaluations is performed with ultrasonographic examination to determine the exact locations of pregnancy and IUD.…”

Section: Introductionmentioning

confidence: 99%

Perinatal outcomes with a copper intrauterine device in situ after 28 weeks of gestation: a retrospective cohort study of sole center in southeast China.

Chen

Zhao

Cao

et al. 2022

Preprint

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Purpose: The purpose of this study was to investigate the pregnancy outcomes with a copper intrauterine device (IUD) in situ after 28 weeks of gestation and the association between pregnancy with copper IUDs and neonatal congenital malformations. Methods: This retrospective cohort study had compared the singleton pregnancies with the copper IUDs in situ and without IUDs after 28 gestational weeks in one delivery center of southeast China. The pregnant outcomes as preterm birth, premature rupture of membranes, infections and neonatal congenital malformations were observed and compared. The statistical analysis was carried out using R (version 4.0.4; R Development Core Team) statistical software. Results: A total of 147 pregnant women were included in our study, 73 with copper IUDs in situ were categorized into case group and 74 without IUDs during pregnancy into control group. In case group, the rates of premature rupture of membranes (38.36%) and spontaneous preterm birth (23.29%) were significantly high compared to control group. Women of elder age (≥35 years) in case group were more likely to experience premature rupture of membranes. The rates of neonatal congenital malformation were 10.96% (8/73) in case group and 1.35% (1/74) in control group respectively with no statistically significant difference. Conclusion: We had found that a copper IUD with pregnancy in situ increased the risk of premature rupture of membranes and spontaneous preterm birth after 28 gestation weeks, nearly one fourth of those women were encountered spontaneous preterm birth, but not increased risk of neonatal congenital malformations.

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Teratogenic effects of Silastic intrauterine devices in the rat with or without added medroxyprogesterone acetate

Barlow¹,

Knight²

1983

Fertility and Sterility

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Intrauterine exposure to copper IUDs and prenatal development in the rat

Cited by 5 publications

References 21 publications

Development of Human Embryos in the Presence of a Copper Intrauterine Device

Development of Human Embryos in the Presence of a Copper Intrauterine Device

Perinatal outcomes with a copper intrauterine device in situ after 28 weeks of gestation: a retrospective cohort study of sole center in southeast China.

Teratogenic effects of Silastic intrauterine devices in the rat with or without added medroxyprogesterone acetate

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