Intrauterine administration of hCG immediately after oocyte retrieval and the outcome of ICSI: a randomized controlled trial

Navali, Nazli; Gassemzadeh, A.; Farzadi, Laya; Abdollahi, Sedigheh; Nouri, Mohammad; Hamdi, Kobra; Mallah, Fateme; Jalilvand, Faranak

doi:10.1093/humrep/dew236

Cited by 28 publications

(34 citation statements)

References 20 publications

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“…Beneficial effects of intrauterine hCG injection before ET on outcomes of IVF/ICSI cycles have been reported by many authors [8, 15]. The first study by Mansour et al [3] found that intrauterine hCG injection before ET improved IVF/ICSI outcomes, with the pregnancy rate of the 500 IU hCG-group significantly higher than the control group’s rate.…”

Section: Discussionmentioning

confidence: 97%

See 1 more Smart Citation

Effect of intrauterine injection of human chorionic gonadotropin before fresh embryo transfer on IVF and ICSI outcomes: a meta-analysis

Hou

Shi

Cai

et al. 2018

Arch Gynecol Obstet

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PurposeThis analysis was performed to evaluate the effects of intrauterine injection of human chorionic gonadotropin (hCG) before fresh embryo transfer (ET) on the outcomes of in vitro fertilization and intracytoplasmic sperm injection.MethodsRandomized controlled trials (RCTs) were identified by searching electronic databases. The outcomes of live birth, clinical pregnancy, implantation, biochemical pregnancy, ongoing pregnancy, ectopic pregnancy, and miscarriage between groups with and without hCG injections were analyzed. Summary measures were reported as risk ratios (RR) with 95% confidence intervals.ResultsSix RCTs on fresh embryo transfer (ET) were included in the meta-analysis. A total of 2759 women undergoing fresh ET were enrolled (hCG group n = 1429; control group n = 1330). Intrauterine injection of hCG significantly increased rates of biochemical pregnancy (RR 1.61) and ongoing pregnancy (RR 1.58) compared to controls. However, there were no significant differences in clinical pregnancy (RR 1.11), implantation (RR 1.17), miscarriage (RR 0.91), ectopic (RR 1.65) or live birth rates (RR 1.13) between the hCG group and control group.ConclusionThe current evidence for intrauterine injection of hCG before fresh ET does not support its use in an assisted reproduction cycle.

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Section: Discussionmentioning

confidence: 97%

“…Several studies have examined the role of intrauterine hCG injection before fresh embryo transfer in ART, but the results have been inconsistent [3, 5, 8, 14–16]. Therefore, we conducted a meta-analysis to investigate whether intrauterine injection of hCG before fresh embryo transfer improves IVF/ICSI outcomes.…”

Section: Introductionmentioning

confidence: 99%

Effect of intrauterine injection of human chorionic gonadotropin before fresh embryo transfer on IVF and ICSI outcomes: a meta-analysis

Hou

Shi

Cai

et al. 2018

Arch Gynecol Obstet

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“…14 More than 10 randomized controlled trials have been reported 18,[103][104][105][106][107][108][109][110][111][112] (summarized in Table 1), and two meta-analyses were conducted to evaluate the efficacy of this treatment. 14 More than 10 randomized controlled trials have been reported 18,[103][104][105][106][107][108][109][110][111][112] (summarized in Table 1), and two meta-analyses were conducted to evaluate the efficacy of this treatment.…”

Section: Effec T Of I U I -H Cg In Art C Yclementioning

confidence: 99%

“…The reported clinical pregnancy rates were controversial when the IUI-hCG was performed before cleavage-stage transfer,103,105,106,108,111 while there was no improvement in IVF-ET outcome when the intervention was conducted before blastocyst transfer regardless of embryonic quality. The reported clinical pregnancy rates were controversial when the IUI-hCG was performed before cleavage-stage transfer,103,105,106,108,111 while there was no improvement in IVF-ET outcome when the intervention was conducted before blastocyst transfer regardless of embryonic quality.…”

mentioning

confidence: 99%

Intrauterine infusion of human chorionic gonadotropin before embryo transfer in IVF/ET cycle: The critical review

Zhang

Chen

Wang

et al. 2019

American J Rep Immunol

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Intrauterine infusion of human chorionic gonadotropin (IUI‐hCG) has been proposed to improve the outcome of in vitro fertilization‐embryo transfer (IVF‐ET), since it plays a critical role in synchronizing endometrial and fetal development. As the early mediator from embryo, hCG promotes the decidualization, angiogenesis, maternal immune tolerance, and trophoblast invasion, favoring successful implantation of embryo. Although multiple clinical trials have been conducted to verify the efficacy of IUI‐hCG on IVF‐ET outcome in recent years, the findings remained controversial. The difference in study design and population might be the cause to the different consequences after administration of hCG. More importantly, the endometrial receptivity, which might affect the efficacy of IUI‐hCG, has not been assessed in women receiving this intervention. Selecting the right population suitable for IUI‐hCG based on known etiology would be crucial in enhancing its efficacy and minimize any possible complications. Investigation of optimal indications for IUI‐hCG should be highlighted in the future.

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“…In that view, since 2011, several reports have been published upon this issue with conflicting results [37,38,39,40,41,42]. Although randomized controlled trials with proper design have been conducted, the published evidence up to now has featured large heterogeneity.…”

Section: Hcg and Clinical Applications In Assisted Reproduction Tementioning

confidence: 99%

The Role of HCG in Implantation: A Mini-Review of Molecular and Clinical Evidence

Makrigiannakis

Vrekoussis

Zoumakis

et al. 2017

IJMS

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Embryo implantation is a complex process involving continuous molecular cross-talk between the embryo and the decidua. One of the key molecules during this process is human chorionic gonadotropin (HCG). HCG effectively modulates several metabolic pathways within the decidua contributing to endometrial receptivity. Herein, a brief overview of the molecular mechanisms regulated by HCG is presented. Furthermore, we summarize the existing evidence regarding the clinical impact on reproductive outcomes after endometrial priming with HCG prior to embryo transfer. Although promising, further evidence is needed to clarify the protocol that would lead to beneficial outcomes.

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Intrauterine administration of hCG immediately after oocyte retrieval and the outcome of ICSI: a randomized controlled trial

Abstract: 2 September 2015.

Cited by 28 publications

References 20 publications

Effect of intrauterine injection of human chorionic gonadotropin before fresh embryo transfer on IVF and ICSI outcomes: a meta-analysis

Effect of intrauterine injection of human chorionic gonadotropin before fresh embryo transfer on IVF and ICSI outcomes: a meta-analysis

Intrauterine infusion of human chorionic gonadotropin before embryo transfer in IVF/ET cycle: The critical review

The Role of HCG in Implantation: A Mini-Review of Molecular and Clinical Evidence

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