2015
DOI: 10.1111/coa.12449
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Intratympanic therapy in Meniere's syndrome or disease: up to date evidence for clinical practice

Abstract: On the basis of 6 RCT's (n = 242), there is evidence to support the effectiveness of intratympanic steroids and gentamicin to control symptoms of vertigo in MS/D albeit with a risk of hearing loss with gentamicin. However, there was no consensus found on doses or treatment protocols. There was no evidence to support the use of other forms of intratympanic therapy (antivirals and latanoprost) in MS/D.

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Cited by 40 publications
(32 citation statements)
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“…Barrs et al in their study reported reduction in the pain after adding 0.1 ml of lidocaine [11]. There is no consensus in the literature regarding appropriate dosing and duration of treatment [12]. Martin Sanz E et al compared the efficacy of daily and weekly intratympanic steroids and, found not many differences in the outcome [13].…”
Section: Discussionmentioning
confidence: 99%
“…Barrs et al in their study reported reduction in the pain after adding 0.1 ml of lidocaine [11]. There is no consensus in the literature regarding appropriate dosing and duration of treatment [12]. Martin Sanz E et al compared the efficacy of daily and weekly intratympanic steroids and, found not many differences in the outcome [13].…”
Section: Discussionmentioning
confidence: 99%
“…For those who do not experience improvement of their symptoms with conservative medical management (e.g., low salt diet, diuretics, betahistine), intratympanic injections of corticosteroids and aminoglycosides have been proven to provide benefit in reduction of vertigo frequency and other symptoms of Menière's disease. When dosed conservatively and using a titration schedule with infrequent dosing, IT gentamicin provides good control of vertiginous symptoms with minimal risk to hearing [69, 7477]. Hearing loss and vestibular hypofunction, however, continue to be a risk of IT gentamicin due to its ablative nature and cocheotoxicity [69, 7478•].…”
Section: Discussionmentioning
confidence: 99%
“…When dosed conservatively and using a titration schedule with infrequent dosing, IT gentamicin provides good control of vertiginous symptoms with minimal risk to hearing [69, 7477]. Hearing loss and vestibular hypofunction, however, continue to be a risk of IT gentamicin due to its ablative nature and cocheotoxicity [69, 7478•]. Vestibular hypofunction is often associated with imbalance during rapid ipsilateral head movements and other symptoms such as oscillopsia [106, 107].…”
Section: Discussionmentioning
confidence: 99%
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