Intratympanic injection of dexamethasone for controlling subjective idiopathic tinnitus

Weshahy, Hussein Fared; Mohamed, Enass Sayed; Salem, Mohamed A.; Hussein, Marwa M.

doi:10.4103/1012-5574.168318

Cited by 2 publications

(2 citation statements)

References 22 publications

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“…In cases of long-standing tinnitus, the symptom can be extremely bothersome and may even lead to depression. 9 Most patients who have experienced tinnitus discuss it as a roaring or high-pitched noise with varying intensities, often related to mood and surroundings. Patients usually complain of increasing intensities in serene surroundings.…”

Section: Discussionmentioning

confidence: 99%

“…These two mechanisms, coupled with increased blood supply to cochlea under the influence of Dexamethasone, make it a viable treatment option for tinnitus. 8,9 The intra-tympanic route for delivering a required amount of steroid is the most viable option and combining long-acting steroids like Dexamethasone with Lidocaine theoretically gives added advantage over steroid-alone infusion. This rationale was Effectiveness of Intratympanic Dexamethasone Pak Armed Forces Med J 2022; 72 (2): 445 employed in this study with subjective measurement to improve tinnitus.…”

Section: Introductionmentioning

confidence: 99%

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Effectiveness of Intratympanic Dexamethasone with Lidocaine for Alleviation of Tinnitus

Ayub

Ahmed

Afzal

et al. 2022

PAFMJ

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Objective: To determine the effectiveness of Intratympanic Dexamethasone with Lidocaine in control of idiopathic tinnitus. Study Design: Randomized control trial (Clinical Trials. gov Identifier: NCT04798391). Place and Duration of Study: ENT Department, PAF Hospital, Sargodha Pakistan, from Apr 2017 to Jul 2019. Methodology: 264 consenting patients with idiopathic unilateral tinnitus presenting at ENT Department PAF Hospital Sargodha were assessed for tinnitus severity using the modified tinnitus handicap inventory. The scores were recorded and subsequently administered intra-tympanicaly 2.0ml (milli-liter) of Dexamethasone and Lidocaine (1.5 ml Dexamethasone ± 0.5 ml 1% Lidocaine). The dose was repeated twice at weekly intervals. All the patients were reassessed on the modified tinnitus handicap inventory two weeks after the third Intra-tympanic administration, with patients divided into responsive and noresponsive groups depending on ten points or more improvement in tinnitus score. Results: Mean modified tinnitus handicap inventory score pre-therapy was 29.6 ± 5.68, and post-therapy was 17.1 ± 7.45. Independent-sample T-test applied showed a p-value of <0.001. Conclusion: Intratympanic Dexamethasone with lidocaine has a definitively positive outcome on tinnitus improvement.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Effectiveness of Intratympanic Dexamethasone with Lidocaine for Alleviation of Tinnitus

Ayub

Ahmed

Afzal

et al. 2022

PAFMJ

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Intratympanic Dexamethasone Injection in Chronic Tinnitus Associated with SNHL

Ali¹,

Ewida

2018

The Medical Journal of Cairo University

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Background: Tinnitus is a common distressing complain characterized by perceived sensation of sound without an external stimulus. Intra-tympanic (IT) dexamethasone injection is used for the treatment of tinnitus associated with sensory neural hearing loss (SNHL) by introducing dexamethasone through the tympanic membrane, leading to decreasing systemic toxicity and a higher perilymph steroid level. Aim of the Study:The aim of this study was to express our experience in evaluation the effect of IT dexamethasone injection for controlling idiopathic chronic tinnitus of cochlear origin associated with SNHL. Patients and Methods:A prospective interventional study of eighty patients with subjective idiopathic tinnitus associated with SNHL for at least 1 year were treated by IT injection of dexamethasone, once per week for 4 weeks. Improvement in tinnitus was assessed using pure-tone audiometry, speech audiometry, tinnitus matching test, and Tinnitus Handicap Inventory by comparing the results before and after therapy. Follow-up after the end of the four injections, 1 and 3 months later.Results: Pure-tone audiometry did not show significant improvement. However, there was a significant improvement in speech audiometry, tinnitus loudness, and Tinnitus Handicap Inventory after the end of the four injections and in the subsequent evaluations 1 and 3 months later.Conclusion: IT dexamethasone injection could be a simple and effective method for controlling subjective idiopathic chronic tinnitus. The tinnitus may not disappear, but could be markedly decreased and easily tolerated.

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Intratympanic injection of dexamethasone for controlling subjective idiopathic tinnitus

Cited by 2 publications

References 22 publications

Effectiveness of Intratympanic Dexamethasone with Lidocaine for Alleviation of Tinnitus

Effectiveness of Intratympanic Dexamethasone with Lidocaine for Alleviation of Tinnitus

Intratympanic Dexamethasone Injection in Chronic Tinnitus Associated with SNHL

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