Intratumoral levels and prognostic significance of &lt;i&gt;Fusobacterium nucleatum&lt;/i&gt; in cervical carcinoma

Huang, Shuting; Chen, Jing; Lian, Li-Yin; Cai, Haibo; Zeng, Haishan; Zheng, Min; Liu, Mubiao

doi:10.18632/aging.104188

Cited by 24 publications

(26 citation statements)

References 20 publications

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“…In addition, we detected an independent positive correlation with the use of IUDs and Fusobacterium sp. Fusobacterium has been studied as a possible diagnostic biomarker of cervical cancer because it is positively correlated with tumor differentiation ( 36 ). Furthermore, Fusobacteriaceae have been reported as the most abundant microorganisms in cervical carcinoma ( 37 ).…”

Section: Discussionmentioning

confidence: 99%

Cervical Squamous Intraepithelial Lesions Are Associated with Differences in the Vaginal Microbiota of Mexican Women

et al. 2021

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Section: Discussionmentioning

confidence: 99%

Cervical Squamous Intraepithelial Lesions Are Associated with Differences in the Vaginal Microbiota of Mexican Women

et al. 2021

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“…Regardless, F. nucleatum should be considered a risk factor for CRC, and targeting F. nucleatum in the treatment of CRC may help improve the prognosis of patients with CRC. (Truant et al, 1983;Ford et al, 2005;De Socio et al, 2009;Swidsinski et al, 2011;Lee et al, 2012;Mitsuhashi et al, 2015;Yamamura et al, 2016;Rodrıǵuez Duque et al, 2018;Vander Haar et al, 2018;Hashemi Goradel et al, 2019;Abushamma et al, 2020;Barrera-López et al, 2020;Boehm et al, 2020;Cao et al, 2020;Huang et al, 2020;Kenig et al, 2020;Parhi et al, 2020;Swaminathan and Aguilar, 2020;Hoffmeister et al, 2021).…”

Section: Crcmentioning

confidence: 99%

More Than Just a Periodontal Pathogen –the Research Progress on Fusobacterium nucleatum

Chen

Huang

Tang

et al. 2022

Front. Cell. Infect. Microbiol.

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Fusobacterium nucleatum is a common oral opportunistic bacterium that can cause different infections. In recent years, studies have shown that F. nucleatum is enriched in lesions in periodontal diseases, halitosis, dental pulp infection, oral cancer, and systemic diseases. Hence, it can promote the development and/or progression of these conditions. The current study aimed to assess research progress in the epidemiological evidence, possible pathogenic mechanisms, and treatment methods of F. nucleatum in oral and systemic diseases. Novel viewpoints obtained in recent studies can provide knowledge about the role of F. nucleatum in hosts and a basis for identifying new methods for the diagnosis and treatment of F. nucleatum-related diseases.

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“…Fusobacterium nucleatum , though not one of the most abundant species contributing to the predictive models, but with a greater than 4-fold presence in HG vs benign, has been found to promote tumor growth (28), associate with high microsatellite instability (29), and induce chemotherapy resistance (30). Patients with cervical cancer who have high levels of intratumoral F. nucleatum have worse progression free and overall survival (31). In colorectal cancer (CRC), the bacterium secretes the adhesin Fap2, which binds to galactose N- acetyl-D-galactosamine (Gal-GalNAc), facilitating the enrichment of tumor cells (30).…”

Section: Discussionmentioning

confidence: 99%

Vaginal microbiome is associated with endometrial cancer grade and histology

Hakimjavadi

George

Taub

et al. 2022

Preprint

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Background: The vaginal microbiome is an underexplored environment which may yield insights about endometrial cancer (EC) pathophysiology and serve as an early marker of disease. Our objective was to evaluate the preoperative vaginal microbiome in women undergoing hysterectomy for benign conditions and EC to identify patterns which could segregate benign disease from EC, and to assess if the microbiome distinguishes low-grade (LG) from high-grade (HG) histologies. Methods: Vaginal microbiome samples were prospectively collected at the time of hysterectomy, and clinicopathologic data collected. Extracted DNA underwent shotgun metagenomics sequencing. Microbial diversity was calculated using the Shannon Index (α-diversity) and PERMANOVA (β-diversity). Hierarchical clustering was used to describe community state types (CST), which were then compared by microbial diversity and grade. Machine learning was utilized to assess the predictive value of grade and histology based on relative bacterial abundance. Results: 61 patients participated: 1) benign gynecologic disease (n=11), 2) LG EC (n=30), and 3) HG EC (n=20). 40 (62.5%) were White, 22 (34.3%) were Black, and 37 (57.8%) were Hispanic. Both α- and β-diversity were associated with tumor grade (p=0.026 and p=0.035, respectively). Four CST were identified that associated with grade of disease (p=0.036). Different histologies demonstrated variation in CST even within tumor grades (p=0.017). Markers at the species level informed models that predicted benign vs cancer (AUC 0.878), HG versus benign (AUC=0.803), and HG versus LG (AUC=0.771) with high accuracy. Conclusions: The vaginal microbiome segregates benign disease from EC, and is predictive of histology and grade, suggesting it may be an effective tool for screening.

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Intratumoral levels and prognostic significance of <i>Fusobacterium nucleatum</i> in cervical carcinoma

Cited by 24 publications

References 20 publications

Cervical Squamous Intraepithelial Lesions Are Associated with Differences in the Vaginal Microbiota of Mexican Women

Cervical Squamous Intraepithelial Lesions Are Associated with Differences in the Vaginal Microbiota of Mexican Women

More Than Just a Periodontal Pathogen –the Research Progress on Fusobacterium nucleatum

Vaginal microbiome is associated with endometrial cancer grade and histology

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