Intratubular Germ Cell Neoplasia of the Testis, Bilateral Testicular Cancer, and Aberrant Histologies

Dhillon, Jasreman; Sexton, Wade J.

doi:10.1016/j.ucl.2015.04.002

Cited by 14 publications

(10 citation statements)

References 83 publications

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“…In this case we have to consider the presence of TIN (testicular intraepithelial neoplasia), now commonly known as intratubular germ cell neoplasia (ITGCN) [33, 34], or stem cell factor receptor c-KIT [25] in the surgical multiple biopsies taken from the remaining parenchyma, as some authors advise [35]. It is especially important to pay attention to the presence of ITGCN because it is considered a premalignant lesion.…”

Section: Resultsmentioning

confidence: 99%

Synchronous bilateral testis cancer: clinical and oncological management

Campobasso¹,

Ferretti

Frattini³

2017

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Synchronous bilateral testis cancer (SBTC) is a rare event. It represents only 0.5–1% of all new cases of testicular cancer. Patients with this disease require careful management for psychological, oncological, and medical problems.We performed a PubMed search for all series that reported SBTC. We considered only articles in English, reporting on more than three cases. We also performed an analysis of the reported evidence regarding testosterone replacement and surgical treatment.We found 10 studies satisfying inclusion criteria for a total of 73 patients. The majority are bilateral seminoma, which present with a low stage at diagnosis, and mixed histology tumours, both with a good overall survival. On the other hand, cases with bilateral non-seminoma histology are associated with poor prognosis and high stage at presentation.Testis-sparing surgery should be an eligible choice in selected cases, to preserve fertility and avoid testosterone deficiency. Multiple biopsies are recommended in these patients, and in the case of intratubular germ cell neoplasia (ITGCN) presence, scrotal radiotherapy is mandatory. Subcutaneous testosterone pellets guarantee higher patient acceptance and physiological testosterone levels. Lifelong follow-up and psychological support, with special care for infertility and erectile dysfunction, must be considered in this cohort of patients.

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Section: Resultsmentioning

confidence: 99%

Synchronous bilateral testis cancer: clinical and oncological management

Campobasso¹,

Ferretti

Frattini³

2017

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“…Testicular leiomyoma is rare and may be confused with malignancy. IGCN has been reported to be less than 1% in the normal male population, and 0.43% to 0.8% in autopsy studies, with most cases being unilateral [ 6 ].…”

Section: Discussionmentioning

confidence: 99%

“…For patients with unilateral IGCN and a normal contralateral testis, orchiectomy is the preferred treatment option. IGCN in solitary testis is more controversial, with some advocating surveillance with testicular self-examination and others recommending early LDRT [ 6 ].…”

Section: Discussionmentioning

confidence: 99%

Neoplasm of a supernumerary undescended testis: A case report and review of the literature

Boussaffa

Naouar

Ati

et al. 2018

International Journal of Surgery Case Reports

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HighlightsPolyorchidism is a rare congenital abnormality. To the best of our knowledge, this is the first report of leiomyoma in supranumerary testis (SNT).Most cases of polyorchidism are found incidentally during surgery for inguinal hernia, undescended testes, torsion or testicular tumor.There is no consensus regarding the management of SNT. If the SNT is scrotal, most authors recommend conservative management.If nonscrotal SNT is found incidentally during surgery, orchiectomy could be performed because of increased risk of malignancy.Treatment of intratubular germ cell neoplasia includes surveillance, orchiectomy, or low-dose external radiation.

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“…in some other genetic disorders such as Klinefelter's syndrome, Down's syndrome and testicular dysgenesis syndrome, a higher rate of testicular cancer incidence is seen, as it is also seen in men diagnosed earlier with primary testicular cancer 1 . it is thought that tumorigenesis starts in primordial germ cell that fails to differentiate into spermatogonia. This malignant transformation happens in utero and results in a precursor lesion known as intratubular germ-cell neoplasia (iTgCn) 6 . until the onset of testicular hormone changes during puberty, iTgCn does not have invasive potential.…”

Section: Introductionmentioning

confidence: 99%

Treatment of Germ Cell Testicular Cancer

Kunac

Gnjidić

Golubić

et al. 2020

ACC

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germ cell testicular cancer (gCTC) is a malignant neoplasm derived from the primordial germ cell. Although it accounts for approximately 1% of all malignancies in men, it is the most common cancer of younger male population, with the highest incidence between ages 15 and 35. Testicular cancer incidence rate has risen globally over the past several decades, with the average increase in the incidence of testicular cancer in Croatia of 7% per annum from the year 1983 to 2007. Two main groups are seminomas and non-seminomas, each accounting for 50% of cases, and they differ in treatment modalities and response to therapy. Despite increase in the incidence rate, a promising circumstance is that gCTC has become a model of curable cancer. Because of advances in diagnostic procedures, sophisticated radiation techniques and especially the introduction of cisplatin based chemotherapy protocols together with advanced postchemotherapy surgical techniques, curability is expected in about 95% of all patients diagnosed with testicular cancer and over 70% of patients with advanced disease. in this review, we will focus on treatment strategies of primary gCTC.

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Intratubular Germ Cell Neoplasia of the Testis, Bilateral Testicular Cancer, and Aberrant Histologies

Cited by 14 publications

References 83 publications

Synchronous bilateral testis cancer: clinical and oncological management

Synchronous bilateral testis cancer: clinical and oncological management

Neoplasm of a supernumerary undescended testis: A case report and review of the literature

Treatment of Germ Cell Testicular Cancer

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