Intrathyroidal parathyroid carcinoma: a case report and literature review

Benali, Kenza; Aarab, Jihan; Benmessaoud, Houda; Nourreddine, Abdelati; Majjaoui, Sanaa El; Kacemi, H. El; Kebdani, Tayeb; Benjaafar, Noureddine

doi:10.3857/roj.2020.01060

Cited by 7 publications

(9 citation statements)

References 22 publications

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“…Thyroid nodules frequently co‐exist with IPAs 19 and several reports have highlighted concurrent IPA and nonmedullary thyroid carcinoma 61–63 . Moreover, there have also been several reports of intrathyroidal parathyroid carcinoma 64–67 . Other possible differentials include benign and metastatic lymph nodes, where they might be mistaken for partial IPAs if they are adjoining the thyroid.…”

Section: Resultsmentioning

confidence: 99%

“… 61 , 62 , 63 Moreover, there have also been several reports of intrathyroidal parathyroid carcinoma. 64 , 65 , 66 , 67 Other possible differentials include benign and metastatic lymph nodes, where they might be mistaken for partial IPAs if they are adjoining the thyroid. For reference, the differing features of IPAs and potential differentials using common imaging techniques are highlighted in Table 3 .…”

Section: Resultsmentioning

confidence: 99%

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Intrathyroidal parathyroid adenomas: Scoping review on clinical presentation, preoperative localization, and surgical treatment

et al. 2022

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Intrathyroidal parathyroid adenomas (IPAs) are a rare cause of primary hyperparathyroidism. They are often difficult to localize preoperatively and intraoperatively, making diagnosis and treatment challenging. Current data on IPAs are sparse and fragmented in the literature. This makes it difficult to compare the effectiveness of different imaging and surgical techniques. To address this issue, this scoping review maps the literature on IPAs, focusing on four domains: clinical presentation, current localization methods, different surgical techniques, and histopathological features. A search of MEDLINE, Embase, and the Cochrane Library was conducted, with 19 studies meeting the inclusion criteria. The characteristics of IPAs on ultrasound, fine‐needle aspiration, CT, MRI, sestamibi‐based techniques, and selective venous sampling are summarized. Emerging imaging modalities, including autofluorescence, are introduced. Surgical methods and intraoperative factors that correlate with high success rates for removal are highlighted. This review also identifies gaps in knowledge to guide further research into this area.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Intrathyroidal parathyroid adenomas: Scoping review on clinical presentation, preoperative localization, and surgical treatment

et al. 2022

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“…Usually, there are two pairs of PTGs, but the incidence of supernumerary glands occurs on average in 15% of cases (range 3–25%), wherein their number can reach 12 pieces. Intrathyroidal location of PC is extremely rare, about 20 such cases have been described in the literature ( 5 , 6 ). Intrathyroid PC was more common in women ( n = 14) with a median age of diagnosis of 56 (36; 63) years.…”

Section: Discussionmentioning

confidence: 99%

Silent intrathyroid parathyroid carcinoma

Kim

Bondarenko

Eremkina

et al. 2023

Endocrinology, Diabetes &Amp; Metabolism Case Reports

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Summary A 59-year-old male presented with an accidental thyroid mass in 2022. Ultrasound and CT scan showed a nodule 5.2 × 4.9 × 2.8 cm (EU-TIRADS 4) in the right lobe of the thyroid gland. Taking into account the results of the fine needle aspiration biopsy (Bethesda V), intrathyroid localization, and absence of clinical symptoms, a malignant tumor of the thyroid gland was suspected. The patient underwent total thyroidectomy using fluorescence angiography with indocyanine green, and two pairs of intact parathyroid glands were visualized in typical localization. Unexpected histological and immunohistochemistry examinations revealed parathyroid carcinoma. Due to the asymptomatic course of the disease and atypical localization of parathyroid tumor, primary hyperparathyroidism was not suspected before the surgery. The diagnosis of asymptomatic intrathyroid parathyroid cancer is a serious diagnostic challenge for a wide range of specialists. Learning points Parathyroid cancer is a rare disease that may be asymptomatic. Intrathyroidal localization of parathyroid carcinoma is casuistic and challenging for diagnosis, and the treatment strategy is not well defined. Preoperative parathyroid hormone and serum calcium testing are recommended for patients with solid thyroid nodules (Bethesda IV–V).

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“…The pathogenesis of parathyroid cancer remains obscure [ 11 ]. Surgery is the corner stone of the cure.…”

Section: Discussionmentioning

confidence: 99%

Intrathyroidal parathyroid carcinoma presenting as thyroid nodule: Case report of unusual location

Said¹,

Allaoui²,

Soukaina³

et al. 2022

Annals of Medicine &Amp; Surgery

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Intrathyroidal parathyroid carcinoma: a case report and literature review

Cited by 7 publications

References 22 publications

Intrathyroidal parathyroid adenomas: Scoping review on clinical presentation, preoperative localization, and surgical treatment

Intrathyroidal parathyroid adenomas: Scoping review on clinical presentation, preoperative localization, and surgical treatment

Silent intrathyroid parathyroid carcinoma

Intrathyroidal parathyroid carcinoma presenting as thyroid nodule: Case report of unusual location

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