Intrathrombotic Pressure of a Thrombosed Abdominal Aortic Aneurysm

Takagi, Hisato; Yoshikawa, S; Mizuno, Yoshimasa; Matsuno, Yukihiro; Umeda, Yohtaro; Fukumoto, Yukiomi; Mori, Yoshio

doi:10.1007/s10016-004-0141-3

Cited by 20 publications

(11 citation statements)

References 14 publications

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“…These results imply that a mural aneurysmal thrombus does not significantly decrease the pressure on the aneurysmal wall, even in a thrombosed aneurysm. Our findings are in agreement with those of Schurink, Takagi and colleagues [2,3]. …”

Section: Discussionsupporting

confidence: 94%

Complete abdominal aortic aneurysm thrombosis and obstruction of both common iliac arteries with intrathrombotic pressures demonstrating a continuing risk of rupture: a case report and review of the literature

et al. 2009

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IntroductionAlthough mural thrombus in an abdominal aortic aneurysm is frequent and its role has been studied extensively, complete thrombosis of an abdominal aneurysm is extremely rare and its natural history in relation to the risk of rupture is not known. The case of a patient with a completely thrombosed infrarenal aneurysm is presented along with a literature review.Case presentationWe report the case of a 56-year-old Caucasian man with an infrarenal abdominal aortic aneurysm, presenting at our hospital due to critical ischemia of his right lower limb. Computed tomography and angiography demonstrated complete aneurysm thrombosis and obstruction of both common iliac arteries.ConclusionDuring the operation, systolic and mean intrathrombotic pressures, measured in different levels, constituted 74.5-90.2% and 77.5-92.5% of systolic and mean intraluminal pressure and 73-88.4% and 76.5-91.3% of systemic pressure, respectively. Our findings show that there may be a continuing risk of rupture in cases of a thrombosed abdominal aortic aneurysm.

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Section: Discussionsupporting

confidence: 94%

Complete abdominal aortic aneurysm thrombosis and obstruction of both common iliac arteries with intrathrombotic pressures demonstrating a continuing risk of rupture: a case report and review of the literature

et al. 2009

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“…Schurink et al 22 in 2000 used a 19-ga needle to measure intrathrombotic pressure just inside the aneurysm wall and found that intrathrombotic pressures correlated well with systemic pressure, thus showing that thrombus did not reduce the mean or pulse pressure on the aneurysm wall. 22 Takagi et al 23 performed similar experiments in patients with complete AAA thrombosis and reached similar conclusions. In contrast, there are many studies, many of them using computational analysis and biomechanical modeling that suggest thrombus decreases wall stress and thus protects against rupture risk.…”

Section: Discussionsupporting

confidence: 63%

Incidental Discovery of a Chronically Thrombosed Abdominal Aortic Aneurysm: Case Report and Literature Review

Rectenwald

2015

Annals of Vascular Surgery

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“…A question of interest arises regarding whether such PWS values derived from the computational estimations should be taken into account, since AAA rupture rarely takes place at these sites, 43 reserving this possibility only for thrombosed AAAs. 20 Another factor that influences the ability of intraluminal thrombus to efficiently reduce PWS (thus lowering the rupture risk, provided that wall strength is unaffected) is its distribution. This is an issue that has not been given much attention in the relevant literature.…”

Section: ¤ ¤mentioning

confidence: 99%

“…18,19 The above has been reported to hold true even in thrombosed aneurysms. [20][21][22][23][24][25][26] The mechanical properties of ILT that are typically utilized in computational patientspecific AAA models are derived from population mean parameters for ILT material characteristics. Initial studies considered ILT as an isotropic, elastic, homogenous, and incompressible material.…”

Section: Role Of Peak Wall Stress (Pws)mentioning

confidence: 99%

Computational Evaluation of Aortic Aneurysm Rupture Risk: What Have We Learned So Far?

Georgakarakos

Ioannou

Papaharilaou

et al. 2011

Journal of Endovascular Therapy

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In current clinical practice, aneurysm diameter is one of the primary criteria used to decide when to treat a patient with an abdominal aortic aneurysm (AAA). It has been shown that simple association of aneurysm diameter with the probability of rupture is not sufficient, and other parameters may also play a role in causing or predisposing to AAA rupture. Peak wall stress (PWS), intraluminal thrombus (ILT), and AAA wall mechanics are the factors most implicated with rupture risk and have been studied by computational risk evaluation techniques. The objective of this review is to examine these factors that have been found to influence AAA rupture. The prediction rate of rupture among computational models depends on the level of model complexity and the predictive value of the biomechanical parameters used to assess risk, such as PWS, distribution of ILT, wall strength, and the site of rupture. There is a need for simpler geometric analogues, including geometric parameters (e.g., lumen tortuosity and neck length and angulation) that correlate well with PWS, conjugated with clinical risk factors for constructing rupture risk predictive models. Such models should be supported by novel imaging techniques to provide the required patient-specific data and validated through large, prospective clinical trials.

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Intrathrombotic Pressure of a Thrombosed Abdominal Aortic Aneurysm

Cited by 20 publications

References 14 publications

Complete abdominal aortic aneurysm thrombosis and obstruction of both common iliac arteries with intrathrombotic pressures demonstrating a continuing risk of rupture: a case report and review of the literature

Complete abdominal aortic aneurysm thrombosis and obstruction of both common iliac arteries with intrathrombotic pressures demonstrating a continuing risk of rupture: a case report and review of the literature

Incidental Discovery of a Chronically Thrombosed Abdominal Aortic Aneurysm: Case Report and Literature Review

Computational Evaluation of Aortic Aneurysm Rupture Risk: What Have We Learned So Far?

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