Intrathecally administered COX-2 but not COX-1 or COX-3 inhibitors attenuate streptozotocin-induced mechanical hyperalgesia in rats

Matsunaga, Aki; Kawamoto, Masashi; Shiraishi, Seiji; Yasuda, Tomoo; Kajiyama, Seiji; Kurita, Seiichiro; Yuge, Osafumi

doi:10.1016/j.ejphar.2006.09.072

Cited by 60 publications

(41 citation statements)

References 44 publications

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“…Here we further found that DB, as well as diclofenac, exhibited strong inhibitory effects on the CCI-induced increases in COX-2 induction, PPT-A mRNA expression, and nociceptive sensitization. Our data are in agreement in part with the previous reports of Matsunaga et al (32) who showed that the inhibition of COX-2, but not COX-1, by selective inhibitors attenuates hyperalgesia in neuropathic rats. Therefore, these results suggest that DB may also have preventive and therapeutic activity on neuropathic pain conditions through inhibition of nociceptive states arising from nerve injury.…”

Section: Discussionsupporting

confidence: 83%

Dragon’s Blood Inhibits Chronic Inflammatory and Neuropathic Pain Responses by Blocking the Synthesis and Release of Substance P in Rats

Wang

Jia

et al. 2012

J Pharmacol Sci

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Abstract. As a traditional Chinese medicine, dragon's blood (DB) is widely used in treating various pains for thousands of years due to its potent anti-inflammatory and analgesic effects. In the present study, we observed that intragastric administration of DB at dosages of 0.14, 0.56, and 1.12 g/kg potently inhibited paw edema, hyperalgesia, cyclooxygenase-2 (COX-2) protein expression, or preprotachykinin-A mRNA expression in carrageenan-inflamed or sciatic nerve-injured (chronic constriction injury) rats, respectively. A short-term (15 s or 10 min) pre-exposure of cultured rat dorsal root ganglion (DRG) neurons to DB (0.3, 3, and 30 μg/ml) or its component cochinchinenin B (CB; 0.1, 1, and 10 μM) blocked capsaicin-evoked increases in both the intracellular calcium ion concentration and the substance P release. Moreover, a long-term (180 min) exposure of cultured rat DRG neurons to DB or CB significantly attenuated bradykinin-induced substance P release. These findings indicate that DB exerts anti-inflammatory and analgesic effects by blocking the synthesis and release of substance P through inhibition of COX-2 protein induction and intracellular calcium ion concentration. Therefore, DB may serve as a promising potent therapeutic agent for treatment of chronic pain, and its effective component CB might partly contribute to anti-inflammatory and analgesic effects.

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Section: Discussionsupporting

confidence: 83%

Dragon’s Blood Inhibits Chronic Inflammatory and Neuropathic Pain Responses by Blocking the Synthesis and Release of Substance P in Rats

Wang

Jia

et al. 2012

J Pharmacol Sci

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“…28 Similarly Matsunaga et al in their study using streptozotocin-induced mechanical hyperalgesia in rats reported that intrathecal administration of PCM did not attenuate hyperalgesia. 29 These findings are inconsistent with results of present study. Im et al have discussed various reasons for obtaining such contradictory results in animal studies including type of animal models used, different animals used for the study, age of the animals and route of administration, all can affect results.…”

Section: Discussioncontrasting

confidence: 99%

Anti-hyperalgesic effect of paracetamol in rat model of thermal hyperalgesia: implications for the treatment of neuropathic pain

Bankar

Dudhgaonkar

2013

Int J Basic Clin Pharmacol

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Background: Neuropathic pain conditions are prevalent in general population and difficult to treat. Most currently available therapies do not provide adequate benefit in all treated patients. Though Paracetamol is available for more than 100 years and have huge safety data, it is still not included in any treatment guidelines for neuropathic pain, as very few studies have evaluated its effects in neuropathic pain conditions. The aim of this study was to evaluate antihyperalgesic activity of paracetamol and to compare it with antihyperalgesic effect of amitriptyline and gabapentin in rat model of thermal hyperalgesia. Methods: Male albino wistar rats weighing 200-250 g of body weight and 4-6 months old were used. After anaesthetizing rats with 2% halothane, mild thermal injury was induced using hot plate analgesiometer. Drugs were administered intraperitoneally 30 minutes after thermal injury. Paw withdrawal latencies were measured at 30, 60, 90 and 120 minutes after drug administration. Statistical analysis done using GraphPad Prism version 5.01 and one way ANOVA followed by post hoc Dunnett's test or Tukey's test were used. Results: Paracetamol showed both dose as well as time dependent antihyperalgesic activity. Gabapentin demonstrated significantly more antihyperalgesic activity compared to amitriptyline (p< 0.05) and paracetamol (p< 0.01). Conclusions: Paracetamol showed antihyperalgesic activity however, it was less as compared to drugs like gabapentin and amitriptyline. Considering the excellent safety profile of paracetamol, it might be useful adjuvant drug for treatment of neuropathic pain conditions. [Int J Basic Clin Pharmacol 2013; 2(3.000): 290-297

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“…A host of other studies have demonstrated the efficacy of NSAIDS in a variety of NMDA sensitive pain models (Ghilardi et al, 2004;Matsunaga et al, 2007) (Hefferan et al, 2003;Ren and Dubner, 1993;Ren et al, 1992b;Zhao et al, 2000) (Malmberg and Yaksh, 1993a) (Dirig et al, 1998). Taken together, these data strongly imply that products of cyclooxygenase activation (prostanoids) are frequently downstream of NMDA receptor activation in vivo.…”

Section: Discussionmentioning

confidence: 98%

Secondary hyperalgesia in the rat first degree burn model is independent of spinal cyclooxygenase and nitric oxide synthase

Sorkin

Doom

Maruyama

et al. 2008

European Journal of Pharmacology

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Various animal models of pain are dependent on activation of different glutamate receptor subtypes. First-degree burn of the paw elicits a secondary hyperalgesia that is dependent on Ca 2++ permeable α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA), but not N-methyl-D-aspartate (NMDA) receptors. The present study takes advantage of that specificity by examining the effects of spinal pretreatments of agents on this secondary hyperalgesia. Rats with indwelling intrathecal catheters were pretreated with agents prior to paw injury. Mechanical withdrawal thresholds were measured before, and for three h after the injury.Spinal pretreatment with cyclooxygenase (10 and 30 μg (S)-(+)-ibuprofen; and 3 and 30 μg ketorolac) and nitric oxide synthase (33 and 100 μg N G Nitro-L-arginine methyl ester hydrochloride (L-NAME) and 10 μg thiocitrulline) inhibitors resulted in no specific anti-allodynia. In contrast, ziconotide (0.3, 1.0 and 3 μg), the N-type voltage gated calcium channel antagonist was very effective in blocking burn-induced sensitivity at all doses used. L-type (Diltiazam 230 μg) and P-type (Agatoxin IVA 0.3 μg) calcium channel blockers produced intermediate effects. Thus, cyclooxygenase and nitric oxide synthase are assumed not to be downstream of Ca 2++ permeable AMPA receptors. Voltage gated calcium channels blockers could exert their effects either pre-or post-synaptically.

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Intrathecally administered COX-2 but not COX-1 or COX-3 inhibitors attenuate streptozotocin-induced mechanical hyperalgesia in rats

Cited by 60 publications

References 44 publications

Dragon’s Blood Inhibits Chronic Inflammatory and Neuropathic Pain Responses by Blocking the Synthesis and Release of Substance P in Rats

Dragon’s Blood Inhibits Chronic Inflammatory and Neuropathic Pain Responses by Blocking the Synthesis and Release of Substance P in Rats

Anti-hyperalgesic effect of paracetamol in rat model of thermal hyperalgesia: implications for the treatment of neuropathic pain

Secondary hyperalgesia in the rat first degree burn model is independent of spinal cyclooxygenase and nitric oxide synthase

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