Intrathecal Vincristine

Fernandez, Conrad V.; Esau, Robert; Hamilton, Don; Fitzsimmons, Barbara; Pritchard, Sheila

doi:10.1097/00043426-199811000-00018

Cited by 42 publications

(9 citation statements)

References 11 publications

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“…This suggests that the physiopathologic mechanisms are similar between vincristine and vindesine, although the time frame may differ. In this case, death occurred 6 weeks after the administration, compared with the reported 2 weeks after vincristine administration intrathecally (2,4). …”

Section: Discussionmentioning

confidence: 57%

“…The intravenous administration of vindesine may lead to side effects, such as peripheral neurologic effects, for example paresthesias, a loss of deep tendon reflexes, or paralytic ileus (1–8). However, vindesine is considered to be less toxic than the other chemotherapeutic agents, especially vincristine.…”

Section: Discussionmentioning

confidence: 99%

“…After intrathecal administration of vincrisitine neuroanatomopathology, examination of the spinal cord showed a formation of neurofilaments aggregates, the destruction of the dynamic cytoskeleton, a pseudocystic transformation with resorption, and inflammation signs. In the brain, there was a degeneration of the myelin and the axons, numerous CD68‐positive macrophages with focal microhemorrhages, edema, a loss of granule and Purkinje cells, and a cystic degeneration of the molecular layer in the cerebellum (1–4,7). This report describes the same lesions in this case of vindesine intrathecal administration.…”

Section: Discussionmentioning

confidence: 99%

“…Because of its action on the neurotubules and the microtubules, the neural tissue is particularly sensitive to the effects of the drug. Some published cases describe inadvertent intrathecal administration of vincristine and described severe and irreversible lesions of the central nervous system (CNS) (1–4). We report here on the first published case of death due to an intrathecal injection of vindesine.…”

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confidence: 99%

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Fatal Accidental Intrathecal Injection of Vindesine

Tournel

Bécart-Robert

et al. 2006

J Forensic Sci

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A 25-year-old woman being treated for non-Hodgkin's lymphoma was accidentally given vindesine intrathecally. The error was recognized immediately and a spinal cord washing was performed through syringing with isotonic saline. However, the patient died 6 weeks later with increasing paralysis, which was followed by neurologic failure. The deceased was autopsied and the central nervous system was removed for a microscopic examination. The results showed microscopic lesions extending from the lumbar to the thoracic portion of the spinal cord, which included pseudocystic transformation of the cells, degeneration of myelin, and microhemorrhages. The brain was edematous and, in the cerebellum, the vermis showed a loss of granule and Purkinje cells. The authors compare this report on vindesine toxicity with cases in the literature involving vincristine. The treating physician admitted responsibility and was sentenced to both a fine and imprisonment.

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Section: Discussionmentioning

confidence: 57%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

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Fatal Accidental Intrathecal Injection of Vindesine

Tournel

Bécart-Robert

et al. 2006

J Forensic Sci

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“…Extensive literature search revealed that the youngest cases reported till now of SPB are of 14 years of age [Table 1]. [2456789] Extramedullary plasmacytoma and multiple plasmacytomas have been reported at very young age as low as 8 years. [1011] However, to the best of our knowledge, this is probably the youngest case of “solitary” osseous plasmacytoma reported in literature.…”

Section: Discussionmentioning

confidence: 99%

Solitary plasmacytoma of bone involving spine in a 12-year-old boy: Report of a rare case and review of literature

et al. 2017

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Solitary plasmacytoma of the bone (SPB) is a rare plasma cell neoplasm representing only about 5% of plasma cell neoplasia. It usually presents as a lytic lesion mainly localized within the axial skeleton. SPB is exceedingly rare in young individuals, and only few cases have been reported so far in patients younger than 20 years of age. In view of rarity of disease, definitive treatment guidelines have not been established. We hereby report a case of SPB involving of lumbar vertebra (L5) in a 12-year-old boy. He was initially treated with antilymphoma therapy and curative radiotherapy considering as primary bone lymphoma. However, he had local recurrence with paraparesis after 9 months which was diagnosed as solitary bone plasmacytoma for which he was treated with decompressive laminectomy and chemotherapy (bortezomib, lenalidomide, and dexamethasone). The purpose of this article is to report a rare case of SPB in a pediatric patient and to review the available literature and treatment options. SPB should be considered in the differential diagnosis of osteolytic bone lesions even in young patients.

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