Intrathecal pramoxine causes long-lasting spinal sensory and motor block in rats

Chou, An‐Kuo; Chiu, Chih-Yi; Han, Ming; Chen, Yu Wen; Wang, Jhi Joung; Hung, Ching Hsia

doi:10.1111/jphp.12894

Cited by 5 publications

(1 citation statement)

References 27 publications

(36 reference statements)

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“…A reduction in the force, representing decreased extensor muscle tone, was considered a motor deficit . A force <20 g (the weight of the ‘flaccid limb’) was recorded as the full absence of extensor postural thrust (100% motor block or 100% MPE) . The maximal block in the time course of spinal block was defined as the %MPE.…”

Section: Methodsmentioning

confidence: 99%

Spinal sensory and motor blockade by intrathecal doxylamine and triprolidine in rats

Tzeng

Chiu

Wang

et al. 2018

Journal of Pharmacy and Pharmacology

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Objectives The aim of this experiment was mainly to examine the effects of intrathecally injected doxylamine and triprolidine, two antihistamine drugs spinal motor and sensory functions. Methods After intrathecally injecting the rats with five different doses, the dose—response curves of spinal sensory and motor block with doxylamine and triprolidine were constructed. In comparison with the local anaesthetic mepivacaine, the quality and duration of spinal anaesthesia with doxylamine or triprolidine were conducted. Key findings Doxylamine, mepivacaine and triprolidine elicited spinal motor and sensory (nociception and proprioception) blockades in a dose‐dependent fashion. On the ED50 (50% effective dose) basis, the rank order of drug potency was triprolidine > mepivacaine > doxylamine (P < 0.05) at provoking spinal motor, proprioceptive and nociceptive blockades. On the equianaesthetic doses (ED25, ED50 and ED75), the duration of spinal anaesthesia with doxylamine was longer (P < 0.01) than that with mepivacaine or triprolidine. Moreover, doxylamine or triprolidine displayed greater potency (ED50) (P < 0.05) and duration (P < 0.05) of sensory block over motor block. Conclusions Doxylamine or triprolidine produces a dose‐dependent effect of spinal motor and sensory block. Triprolidine with a better nociception‐selective action over motor block has a better potency than mepivacaine or doxylamine. Doxylamine and triprolidine produce longer durations than mepivacaine.

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Section: Methodsmentioning

confidence: 99%