Intrathecal Morphine Pump Malfunction Due to Leakage at the Catheter Connection Site: A Rare Problem and Its Prevention

Wörner, J.; Kothbauer, Karl F.; Gerber, Helmut

doi:10.1213/ane.0b013e3181a280e4

Cited by 6 publications

(4 citation statements)

References 5 publications

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“…Despite an extensive literature search, we could not identify comparable cases. However, we found one published case report of leakage due to pump‐catheter connection failure immediately after surgery 6 . Corrosion within the pump is known to cause motor stalls of Synchromed II pumps, for which Medtronic initiated a Class I recall in November 2012 7 .…”

Section: Discussionmentioning

confidence: 99%

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Loss of effectiveness with an implanted drug delivery system for intrathecal pain therapy due to corrosion

Reining

Kretzschmar

2022

Pain Practice

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Introduction: Intrathecal drug delivery is an established invasive treatment option. Most common complication is catheter malfunction, which can lead to overdose or withdrawal. Case Presentation: A 61-year-old female patient underwent an elective replacement of an intrathecal drug delivery pump. The patient complained about a loss of effectiveness over the past 2 years. Intraoperatively, a white mass corresponding to morphine precipitation in the pump pocket was found, which appeared to be due to corrosion at the pump-catheter connection site. Conclusions: Recommendations on how to deal with the decreasing effectiveness of intrathecal drug delivery and on intraoperative catheter handling are provided. K E Y W O R D S corrosion, implantable infusion pumps, intrathecal drug delivery system, opioid analgesicsHow to cite this article: Reining M, Kretzschmar M. Loss of effectiveness with an implanted drug delivery system for intrathecal pain therapy due to corrosion.

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Section: Discussionmentioning

confidence: 99%

“…However, we found one published case report of leakage due to pumpcatheter connection failure immediately after surgery. 6 Corrosion within the pump is known to cause motor stalls of Synchromed II pumps, for which Medtronic initiated a Class I recall in November 2012. 7 The pump design has since been adjusted to reduce motor stalls.…”

Section: Discussionmentioning

confidence: 99%

Loss of effectiveness with an implanted drug delivery system for intrathecal pain therapy due to corrosion

Reining

Kretzschmar

2022

Pain Practice

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“…Desde hace años, la implantación de bombas de infusión continua de opioides es una alternativa terapéutica en el tratamiento de los pacientes que presentan dolor crónico, ya sea oncológico o no oncológico (1).…”

Section: Introductionunclassified

Hipoacusia en un paciente tras administración de morfina intratecal

Pingarrón

Bartol

Vaquero

et al. 2014

Rev. Soc. Esp. Dolor

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Muriel C. Hipoacusia en un paciente tras administración de morfina intratecal. Rev Soc Esp Dolor 2014; 21(2): 89-91. ABSTRACTThe administration of intrathecal opioids is a common technique when treating patients with chronic pain. The chosen drug is morphine due to its pharmacokinetic characteristics that determine a good analgesic quality, still required monitoring of patients for the first 24 hours because of their fundamental risk of respiratory depression.We present a case of hearing loss associated with opioid intoxication after administration of morphine by intrathecal infusion pump in a patient with chronic pain with post-laminectomy syndrome. The patient was treated with respiratory support and continuous intravenous infusion of naloxone. The hearing loss reverted within one hour after gradual increase of the treatment. The different articles that we analyzed include nausea, vomiting, pruritus, urinary retention and respiratory depression as side effects of intrathecal morphine. There is no reference to the onset of hearing loss associated with intrathecal opioid intoxicaton in the literature we have reviewed so far.

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“…However, intrathecal pumps suffer from their own limitations because they are bulky, battery-operated, and not suitable for everyone [9]. Persistent cerebrospinal fluid leak during its insertion is also a known complication [10].…”

Section: Introductionmentioning

confidence: 99%

Prolonged Release of the Local Anesthetic Butamben for Potential Use in Pain Management

Rastogi¹,

Stavchansky²,

Bowman³

2012

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Continuous delivery of local anesthetics might be useful for management of localized and chronic pain. Controlled release injectable anesthetics have been developed but they can deliver the drug for only few days and the release is not zero-order. A drug delivery system (DDS) consisting of a perforated reservoir for drug containment and release and its potential for management of chronic pain is described. Proof of principle is detailed for long-term zero order delivery of butamben. In this study, the DDS was a polyimide tube with a 0.20 mm hole and butamben release was evaluated <i>in vitro</i>. It is envisioned that the DDS could be implanted in proximity to a nerve, enervating the pain source, for long-term control of chronic pain

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Intrathecal Morphine Pump Malfunction Due to Leakage at the Catheter Connection Site: A Rare Problem and Its Prevention

Cited by 6 publications

References 5 publications

Loss of effectiveness with an implanted drug delivery system for intrathecal pain therapy due to corrosion

Loss of effectiveness with an implanted drug delivery system for intrathecal pain therapy due to corrosion

Hipoacusia en un paciente tras administración de morfina intratecal

Prolonged Release of the Local Anesthetic Butamben for Potential Use in Pain Management

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