Intrathecal immune response and virus-specific immunoglobulin M antibodies in laboratory diagnosis of acute poliomyelitis

Roivainen, Merja; Agboatwalla, Mubina; Stenvik, Mirja; Rysä, T; Akram, Dure Samin; Hovi, Tapani

doi:10.1128/jcm.31.9.2427-2432.1993

Cited by 27 publications

(11 citation statements)

References 13 publications

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“…HSV, 27 measles virus, 28 EBV 29 and HCV. 30 IgM missing in a certain percentage of cases during acute infections has been reported for parvovirus B 19, 31 HAV, 32 EBV, 29 Poliomyelitis virus, 33 measles virus, 34 Japanese encephalitis virus, 35 tick-borne encephalitis virus, 36 rubella virus, 37 HCV, 30 and CMV. 38 Whereas missing or apparently late appearing IgM responses may have caused misdiagnosis of acute infections as past infections, the opposite problem was arising through the detection of persistently positive IgM responses for time periods of many months or even few years, as found for borrelia infection, 39 rubella virus, 40,41 EBV, 29 Puumala virus, 42 parvovirus B 19, 43 HCV, 30 and TBE virus.…”

Section: ------------------------------------------------------------mentioning

confidence: 99%

The variability of the serological response to SARS‐corona virus‐2: Potential resolution of ambiguity through determination of avidity (functional affinity)

Bauer

2020

Journal of Medical Virology

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Data on the serological response towards SARS CoV‐2 in 16 recent reports were analyzed and a high degree of variability was shown. IgM responses were either found earlier than IgG, or together with IgG, later than IgG or were missing. Therefore, clear distinctions between early, intermediate and past infections are obviously not possible merely on the basis of IgM and IgG determinations. The review of publications on the serology of other virus groups shows that variable IgM responses can be found as well and therefore are not specific for SARS CoV‐2 infections. A model to explain this variability is proposed. The inclusion of avidity determination into regular diagnostic procedures has allowed to resolve such “atypical” serological constellations. The potential use of avidity determination for the diagnosis of Covid‐19, for risk assessment, epidemiological studies, analysis of cross reactions, as well as for the control of vaccination programs is suggested and discussed. This article is protected by copyright. All rights reserved.

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Section: ------------------------------------------------------------mentioning

confidence: 99%

The variability of the serological response to SARS‐corona virus‐2: Potential resolution of ambiguity through determination of avidity (functional affinity)

Bauer

2020

Journal of Medical Virology

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“…Thus, while detection of IgM in serum may be more sensitive than virus isolation in detecting enterovirus infection (32,96), this provides only circumstantial evidence of an etiologic role in concurrent symptoms. However, detection of virus-specific IgM in CSF is more likely to indicate a causal relationship to CNS symptoms and is more sensitive than isolation of PV from stool for confirming a diagnosis of paralytic poliomyelitis (311,369). Determination of virus-specific IgM in serum has proved useful in monitoring a recent PV outbreak in the Netherlands (326) and in defining the epidemiology of NPEV outbreaks (11,134).…”

Section: Serological Diagnosismentioning

confidence: 99%

Molecular Typing of Enteroviruses: Current Status and Future Requirements

et al. 1998

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Human enteroviruses have traditionally been typed according to neutralization serotype. This procedure is limited by the difficulty in culturing some enteroviruses, the availability of antisera for serotyping, and the cost and technical complexity of serotyping procedures. Furthermore, the impact of information derived from enterovirus serotyping is generally perceived to be low. Enteroviruses are now increasingly being detected by PCR rather than by culture. Classical typing methods will therefore no longer be possible in most instances. An alternative means of enterovirus typing, employing PCR in conjunction with molecular genetic techniques such as nucleotide sequencing or nucleic acid hybridization, would complement molecular diagnosis, may overcome some of the problems associated with serotyping, and would provide additional information regarding the epidemiology and biological properties of enteroviruses. We argue the case for developing a molecular typing system, discuss the genetic basis of such a system, review the literature describing attempts to identify or classify enteroviruses by molecular methods, and suggest ways in which the goal of molecular typing may be realized.

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“…Immunoglobulin class-specific antibodies were analysed by using a heavy-chain-capture RIA against a panel of enterovirus antigens including purified CBV4, CBV5, CAV9, echo1, and procapsid antigens of CBV3 and CBV5, as described previously [Frisk et al, 1989;Roivainen et al, 1993;Hyöty et al, 1995]. IgG-class antibodies were also analysed using an EIA method against a synthetic peptide antigen (amino acid sequence KEVPALTAVETGAT-C) derived from an immunodominant region of capsid protein VP1 [Roivainen et al, 1991], known to be a common antigenic determinant for several enteroviruses .…”

Section: Solid Phase Assay For Enterovirus Antibodiesmentioning

confidence: 99%

Several different enterovirus serotypes can be associated with prediabetic autoimmune episodes and onset of overt IDDM

Roivainen¹,

Knip²,

Hyöty³

et al. 1998

J. Med. Virol.

116

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In a prospective multicentre study described previously on prediabetic events in siblings of index cases with insulin-dependent diabetes mellitus, 31 children developed clinical diabetes during the observation period and 51 children seroconverted for islet cell antibodies or insulin autoantibodies. By using nonserotype specific EIA and RIA, it has shown recently that enterovirus infections in both groups were frequently associated with increases of islet cell antibody and/or insulin autoantibody titres. Serum specimens sequentially collected from 12 children during the prediabetic period were still available and were then tested for serotype-specific neutralizing antibodies. Plaque-neutralization assays were carried out for coxsackievirus A9, coxsackievirus B types 1 to 6, and echovirus types 1 and 11. An unequivocal monotypic increase in neutralizing antibodies was observed on seven occasions in six children, on one occasion with coxsackievirus A9, one with coxsackievirus B1, two with coxsackievirus B2, two with coxsackievirus B3, and one with coxsackievirus B5. In four patients, the infection was associated temporally with increases in the levels of islet cell antibodies, insulin autoantibodies and/or antibodies to glutamic acid decarboxylase, and in three other patients, it coincided with the clinical onset of insulin-dependent diabetes mellitus. These results suggest that the association of enterovirus infections with insulin-dependent diabetes mellitus is not restricted to serotype 4 of coxsackie B viruses suspected previously, but that several different serotypes might play a role in the pathogenesis of the disease.

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Intrathecal immune response and virus-specific immunoglobulin M antibodies in laboratory diagnosis of acute poliomyelitis

Cited by 27 publications

References 13 publications

The variability of the serological response to SARS‐corona virus‐2: Potential resolution of ambiguity through determination of avidity (functional affinity)

The variability of the serological response to SARS‐corona virus‐2: Potential resolution of ambiguity through determination of avidity (functional affinity)

Molecular Typing of Enteroviruses: Current Status and Future Requirements

Several different enterovirus serotypes can be associated with prediabetic autoimmune episodes and onset of overt IDDM

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