Intrathecal delivery of bone marrow stem cells in ALS: A preliminary report

Martínez, Héctor R.; Gómez‐Almaguer, David; Jaime‐Pérez, José Carlos; Olguín-Ramírez, Leticia A.; Sarquis, Rafael Naim G.; Salazar-Riojas, Rosario; León, Andrés Gómez‐De; Ocañas, César E Escamilla; Marioni, Sergio Salazar

doi:10.15761/jto.1000117

Cited by 3 publications

(2 citation statements)

References 24 publications

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“…The system has three facets: the first remembers the taking of medications, the second measures the emotional state of the subjects focuses mainly in electroencephalography (EEG), the third proposes exercises based on the previous determination of the emotional state. In [2] the purpose is to detect the state of relaxation based on physiological signals, specifically in the galvanic skin response (GSR), also called electrodermal activity (EDA). In [3] an experiment is carried out to measure stress in real life, where 16 subjects participate.…”

Section: Review Of the State Of The Artmentioning

confidence: 99%

Emotional State Measurement Trial (EMOPROEXE):a Protocol for Promoting Exercise in Adult and Children with Cerebral Palsy

Gomez-Gonzalez,

Castro-Garcia,

Merino-Monge

et al. 2024

Preprint

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Background: The protocol described in this paper is part of a research project coordinated 1 between three Spanish universities where a technology aimed at improving the quality of life of 2 people suffering from cerebral palsy will be developed. Part of the technology developed will consist 3 of developing an interface and a series of applications to increase motivation for daily physical activity. 4 The basis of these developments is based on the measurement of the emotional state of the subjects. 5 Methods: The experimental protocol is designed with two objectives, on the one hand to identify the 6 emotional state through physiological signals, and on the other to determine whether music can be 7 a motivating factor to promote physical activity. It has been specifically designed for subjects with 8 cerebral palsy taking into account the special characteristics of this population. These are people with 9 whom it is difficult to use questionnaires to have a basis to contrast with the measured physiological 10 signals, so measurements must be taken in carefully chosen daily life situations Discussion: As results 11 we hope to obtain which physiological parameters are the most robust to measure the emotional state 12 and how to design rehabilitation and physical activity promotion routines that are motivating, in 13 addition to being able to avoid risk factors during the performance of these routines. Trial registration: 14 NCT05621057. https://clinicaltrials.gov/ct2/show/NCT05621057

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Section: Review Of the State Of The Artmentioning

confidence: 99%

Emotional State Measurement Trial (EMOPROEXE):a Protocol for Promoting Exercise in Adult and Children with Cerebral Palsy

Gomez-Gonzalez,

Castro-Garcia,

Merino-Monge

et al. 2024

Preprint

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show abstract

“…In another study by Prabhakar et al, stabilization of disease was observed, with no significant decline in ALS FRS-R score over a one-year follow-up duration, following intrathecal administration of autologous bone marrow derived stem cells [14]. A study by Martinez et al suggested slower disease progression in ALS patients during a one year follow up post intrathecal transplantation of bone marrow derived mononuclear cells [105]. In this study, a total decrease of 4 points in the ALS FRS-R score at one year was noted against the usual average decline of 13.32 points.…”

Section: Clinical Studiesmentioning

confidence: 99%

Improved survival in amyotrophic lateral sclerosis patients following autologous bone marrow mononuclear cell therapy: a long term 10-year retrospective study

Sharma

Sane

Paranjape

et al. 2021

Journal of Neurorestoratology

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Background:Promising results from previous studies using cell therapy have paved the way for an innovative treatment option for amyotrophic lateral sclerosis (ALS). There is considerable evidence of immune and inflammatory abnormalities in ALS. Bone marrow mononuclear cells (BMMNCs) possess immunomodulatory properties and could contribute to slowing of disease progression.Objective:Aim of our study was to evaluate the long-term effect of autologous BMMNCs combined with standard treatment on survival duration in a large population and to evaluate effect of type of onset and hormonal status on survival duration in the intervention group.Methods:This controlled, retrospective study spanned over 10 years, 5 months; included 216 patients with probable or definite ALS, 150 in intervention group receiving autologous BMMNCs and standard treatment, and 66 in control group receiving only standard treatment. The estimated survival duration of control group and intervention group was computed and compared using Kaplan Meier analysis. Survival duration of patients with different types of onset and hormonal status was compared within the intervention group.Results:None of the patients reported any major adverse events related to cell administration or the procedure. Kaplan Meier analysis estimated survival duration in the intervention group to be 91.7 months while 49.7 months in the control group (p = 0.008). Within the intervention group, estimated survival was significantly higher (p = 0.013) in patients with limb onset (102.3 months) vs. bulbar onset (49.9 months); premenopausal women (93.1 months) vs. postmenopausal women (57.6 months) (p = 0.002); and preandropausal men (153.7 months) vs. postandropausal males (56.5 months) (p = 0.006).Conclusion:Cell therapy using autologous BMMNCs along with standard treatment offers a promising and safe option for ALS with the potential of long term beneficial effect and increased survival. Limb onset patients, premenopausal women and men ≤ 40 years of age demonstrated better treatment efficacy.

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Stem Cell Homing in Intrathecal Applications and Inspirations for Improvement Paths

Marić¹,

Velikic²,

Marić

et al. 2022

IJMS

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A transplanted stem cell homing is a directed migration from the application site to the targeted tissue. Intrathecal application of stem cells is their direct delivery to cerebrospinal fluid, which defines the homing path from the point of injection to the brain. In the case of neurodegenerative diseases, this application method has the advantage of no blood–brain barrier restriction. However, the homing efficiency still needs improvement and homing mechanisms elucidation. Analysis of current research results on homing mechanisms in the light of intrathecal administration revealed a discrepancy between in vivo and in vitro results and a gap between preclinical and clinical research. Combining the existing research with novel insights from cutting-edge biochips, nano, and other technologies and computational models may bridge this gap faster.

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Intrathecal delivery of bone marrow stem cells in ALS: A preliminary report

Abstract: Introduction: There is no effective therapy for amyotrophic lateral sclerosis (ALS). Safety and feasibility of intrathecal autologous stem cell injections in ALS patients is described.

Cited by 3 publications

References 24 publications

Emotional State Measurement Trial (EMOPROEXE):a Protocol for Promoting Exercise in Adult and Children with Cerebral Palsy

Emotional State Measurement Trial (EMOPROEXE):a Protocol for Promoting Exercise in Adult and Children with Cerebral Palsy

Improved survival in amyotrophic lateral sclerosis patients following autologous bone marrow mononuclear cell therapy: a long term 10-year retrospective study

Stem Cell Homing in Intrathecal Applications and Inspirations for Improvement Paths

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