Intratesticular Bradykinin Involvement in Rat Testicular Pain Models

Abstract

Here, we found that intratesticular bradykinin evokes pain behavior via stimulation of bradykinin B2 receptors and that intratesticular acetic acid injection induces intratesticular bradykinin synthesis, consequently leading to pain behavior. These findings suggest that the potential utility of bradykinin B2 receptor antagonists as a novel target for treating urogenital pain.

Effect of 3-substituted 1,4-benzodiazepin-2-ones on bradykinin-induced smooth muscle contraction

“…Bradykinin (BK) is one of the most potent pain-producing agents formed under inflammatory conditions. Multitude of its sensiti zing and excitatory effects on peripheral nociceptors supporting its role as a prototype of peripheral pain mediators have been described [1,2,6,10]. A number of bradykinin effects mediated by products of the arachidonic acidcyclooxygenase cascade testify to the existence of mutual interactions between the pain mediators [12].…”