Intratesticular alpha1-adrenergic receptors mediate stress-disturbed transcription of steroidogenic stimulator NUR77 as well as steroidogenic repressors DAX1 and ARR19 in Leydig cells of adult rats

Stojkov-Mimic, Natasa J.; Bjelic, Maja M.; Radovic, Sava M.; Mihajlović, Aleksandar I.; Sokanovic, Srdjan J.; Baburski, Aleksandar Z.; Janjic, Marija M.; Kostic, Tatjana S.; Andrić, Silvana A.

doi:10.1016/j.mce.2015.05.019

Cited by 4 publications

(2 citation statements)

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“…Blockade of the α1-adrenergic response can reverse these stress-related decreases in NR4A1 expression. 93 Of most interest, Wang et al demonstrated that NR4A1 levels have been shown to increase markedly following the knockdown of Luman (cAMPresponse element-binding protein 3; CREB3), enhancing steroidogenic gene expression and associated T synthesis. 94 Cryptorchidism is a common developmental abnormality that generally requires surgical intervention to remedy.…”

Section: The Impact Of Nr4a1 Expression On Leydig Cellsmentioning

confidence: 99%

“…Following adrenaline‐induced α1‐adrenergic‐mediated signaling, NR4A1 expression in Leydig cells is reduced, thus affecting steroidogenic activity in response to certain forms of stress. Blockade of the α1‐adrenergic response can reverse these stress‐related decreases in NR4A1 expression 93 . Of most interest, Wang et al demonstrated that NR4A1 levels have been shown to increase markedly following the knockdown of Luman (cAMP‐response element‐binding protein 3; CREB3), enhancing steroidogenic gene expression and associated T synthesis 94 …”

Section: The Role Of Nr4a Receptors In Male Reproductionmentioning

confidence: 99%

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The function of nuclear hormone receptor 4A signaling in the human reproductive system: A review

Wang

Zhang

et al. 2022

J of Obstet and Gynaecol

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Aim: This review aims to summarize the research focused upon the functions of nuclear hormone receptor 4A (NR4A) in the human reproductive system. The research questions addressed are to decipher what role the NR4A subfamily plays in the regulation of the human reproductive system and effects upon fertility issues through regulation of the expression of the NR4A subfamily. Methods: The electronic database PubMed was searched for studies published before November 2021. Keywords included "NR4A," "trophoblast," "decidualization," "folliculogenesis," "estrogen," "pregnancy," "Leydig cells," "fertility," and "reproductive." Relevant references from retrieved manuscripts and review articles were also searched manually. Results: NR4A subfamily are involved in trophoblast differentiation, endometrial decidualization, embryo adhesion, secretion of related hormones, and regulation of spontaneous term labor. Besides, many studies have provided strong evidence that they play critical roles in spermatogenesis. Furthermore, Multiple mechanisms can affect the expression of NR4As. Broadly, NR4A family receptors affect the human reproductive system in multiple ways. Conclusions: Further research is needed to specifically dissect the functions and regulatory mechanisms of these receptors and their pharmaceutical antagonists and agonists. The connection between the NR4A subfamily and a variety of reproductive disorders needs to be proven experimentally such that further examination of human tissue is required to assess the role of these receptors in human reproductive diseases.

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Section: The Impact Of Nr4a1 Expression On Leydig Cellsmentioning

confidence: 99%

Section: The Role Of Nr4a Receptors In Male Reproductionmentioning

confidence: 99%