2000
DOI: 10.1097/00004647-200009000-00006
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Intrastriatal Transplantation of Bone Marrow Nonhematopoietic Cells Improves Functional Recovery After Stroke in Adult Mice

Abstract: The authors transplanted adult bone marrow nonhematopoietic cells into the striatum after embolic middle cerebral artery occlusion (MCAO). Mice (n = 23; C57BL/6J) were divided into four groups: (1) mice (n = 5) were subjected to MCAO and transplanted with bone marrow nonhematopoietic cells (prelabeled by bromodeoxyuridine, BrdU) into the ischemic striatum, (2) MCAO alone (n = 8), (3) MCAO with injection of phosphate buffered saline (n = 5), and (4) bone marrow nonhematopoietic cells injected into the normal st… Show more

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Cited by 469 publications
(309 citation statements)
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“…We also found on day 14 that the MSC-only treated group could significantly reduce the infarction volume under the superacute treatment compared with the PBS-treated group, but not under the acute treatment. This was the same as the Chopp's group had reported, that transplanted MSCs to the transient MCAO model 24 h after ischemia occurred had improved neurological function recovery, but not significantly decreased infarction area Li et al, 2000Li et al, , 2001, while our data of the superacute treatment showed the contrast result. We thought that it might have been caused by the different therapeutic time window.…”
Section: Discussionsupporting
confidence: 90%
“…We also found on day 14 that the MSC-only treated group could significantly reduce the infarction volume under the superacute treatment compared with the PBS-treated group, but not under the acute treatment. This was the same as the Chopp's group had reported, that transplanted MSCs to the transient MCAO model 24 h after ischemia occurred had improved neurological function recovery, but not significantly decreased infarction area Li et al, 2000Li et al, , 2001, while our data of the superacute treatment showed the contrast result. We thought that it might have been caused by the different therapeutic time window.…”
Section: Discussionsupporting
confidence: 90%
“…Effective therapeutics for the rehabilitation of stroke survivors have yet to be developed. Recently Chopp and coworkers reported that rodent bone marrow cells grafted into the ischemic rat brain resulted in functional improvement (32). In this study, however, bone marrow cells were not purified to isolate stem cells.…”
Section: Introductionmentioning
confidence: 85%
“…Modified neurologic severity scores (mNSS): Neurologic function was graded on a scale of 0 to 14 (normal score 0; maximal deficit score 14, see Table 1; Li et al, 2000). mNSS is a composite of motor, reflex and balance tests.…”
Section: Behavioral Testsmentioning
confidence: 99%