Intrasplenic mucinous cystadenoma with mesenchymal stroma arising in pancreatic heterotopia

Mourra, Najat; Balladur, Pierre; Parc, R; Jf, Fléjou

doi:10.1046/j.1365-2559.2003.01608.x

Cited by 5 publications

(3 citation statements)

References 5 publications

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“…There is on record even one case of mucinous cystadenoma with ovarian-like stroma, which arose in pancreatic heterotopia in the spleen [49]. Similar to MESTK, these tumors arise almost exclusively in middle-aged and elderly females, and they represent a distinct entity.…”

Section: Discussionmentioning

confidence: 98%

Mixed epithelial and stromal tumors of the kidney. A report of 22 cases

et al. 2004

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Mixed epithelial and stromal tumor of the kidney (MESTK) is a recently described subset of renal neoplasm that tends to occur in middle-aged and older women and is characterized by a distinctive histological appearance. To further characterize this lesion, we report the clinicopathological and immunohistochemical features of 22 additional cases from our institutional files. Grossly, the tumors ranged in size from 1 cm to 14 cm (mean 6.7 cm), were well circumscribed but unencapsulated, and showed a cystic cut surface. The tumors were composed of a spindle cell proliferation that resembled ovarian stroma, as well as an epithelial component lining the cystic structures, which usually consisted of flat to hobnailed cells typical of collecting-duct epithelium. Areas displaying features of Mullerian differentiation were also documented in 6 cases, including epithelium of endometrioid, tubal, clear cell and squamous cell type as well as one case showing an architecture that closely resembled Mullerian adenofibroma and adenosarcoma. Follow-up in 14 patients (average 4.4 years) showed no evidence of recurrence or metastasis. We believe these tumors represent the renal counterpart of similar mixed epithelial and stromal neoplasms occurring in the biliary tract and pancreas, which is also characterized by cystic structures lined by epithelium, admixed with ovarian-type stroma. The differential diagnosis for these tumors includes cystic nephroma and cystic partially differentiated nephroblastoma, which we believe to represent clinically and morphologically distinct entities from MESTK. In particular, the distinction from cystic nephroma in adult male patients is emphasized, and two cases of this entity are included in the study for comparison.

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Section: Discussionmentioning

confidence: 98%

Mixed epithelial and stromal tumors of the kidney. A report of 22 cases

et al. 2004

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“…Rarely, specific EP-related symptoms may occur, in particular caused by luminal obstruction [ Figure 2 ], inflammation, or, very rarely, by the occurrence of exocrine or endocrine neoplasms in the EP. [ 7 11 14 15 16 17 18 19 20 21 22 23 24 25 26 27 33 34 35 36 37 38 39 40 41 ] Endoscopically, central dimpling is a characteristic feature [ Figure 1 ], described in 35%–90% of cases. [ 49 50 51 52 ] However, mucosal dimpling or umbilication is also observed in submucosal neuroendocrine tumors and hamartomas.…”

Section: Discussionmentioning

confidence: 99%

“…[ 30 31 32 ] Finally, case reports of nearly all distinct types of solid and cystic pancreatic neoplasms including ductal adenocarcinoma, neuroendocrine tumor, acinar cell carcinoma, serous cystadenoma, mucinous cystadenoma, and intraductal papillary mucinous neoplasia arising from EP have been published. [ 33 34 35 36 37 38 39 40 41 ]…”

Section: Introductionmentioning

confidence: 99%

Ectopic pancreas in the upper gastrointestinal tract: Is endosonographic diagnosis reliable? Data from the German Endoscopic Ultrasound Registry and review of the literature

2018

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Background:Ectopic pancreas (EP) belongs to the most frequent subepithelial lesions (SELs) of the upper gastrointestinal (GI) tract. In the majority of cases, it is detected incidentally. Differential diagnosis from mesenchymal subepithelial tumors may be difficult.Methods:Among 24,308 endosonographic examinations and interventions, which were prospectively enrolled in the database of the German Endoscopic Ultrasound (EUS) Registry from January 2009 to August 2013, 575 were performed for suspected SELs of the upper GI tract. Sixty three cases of EP of the upper GI tract (stomach, n = 53; duodenum, n = 10; esophagus, n = 0) were extracted and retrospectively reviewed.Results:In 65.1% of cases, radial echoendoscopes or radial miniprobes were used for examination. Nearly 84% of EP was found in the stomach, 16% in the duodenum, none in the esophagus. In 88.9% of cases, the EUS examination discerned the layer of origin. In 59% of cases EP was described as a heterogeneous, in 28.6% as a homogeneous-hypoechoic and in 7.9% as a homogeneous-echogenic subepithelial mass lesion. Mean diameter was 13.0 mm × 8.1 mm, the mean ratio between long and short axis diameter was 1.75. EUS-guided fine needle aspiration (EUS-FNA) was used to accomplish cytological or histological diagnosis in only 6.3% of cases.Conclusions:EP accounts for 11% of all EUS examinations performed for subepithelial lesions of the upper GI tract and prospectively enrolled in the German EUS registry. Rather than being an eyecatcher, EP is a chameleon with numerous differential diagnoses. In selected cases, EUS-FNA may help clarifying the diagnosis.

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Renal epithelial and stromal tumor: a new term to encompass the spectrum of cystic nephroma and mixed epithelial and stromal tumor of the kidney

Turbiner¹,

Oliva²

2008

Diagnostic Histopathology

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Intrasplenic mucinous cystadenoma with mesenchymal stroma arising in pancreatic heterotopia

Cited by 5 publications

References 5 publications

Mixed epithelial and stromal tumors of the kidney. A report of 22 cases

Mixed epithelial and stromal tumors of the kidney. A report of 22 cases

Ectopic pancreas in the upper gastrointestinal tract: Is endosonographic diagnosis reliable? Data from the German Endoscopic Ultrasound Registry and review of the literature

Renal epithelial and stromal tumor: a new term to encompass the spectrum of cystic nephroma and mixed epithelial and stromal tumor of the kidney

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