INTRASPECIFIC VARIATION IN SCORPION<i>LEIURUS QUINQUESTRIATUS</i>VENOM COLLECTED FROM EGYPT (SINAI AND ASWAN DESERTS)

Omran, Mohamed A.; McVean, Alistair

doi:10.1081/txr-100102322

Cited by 20 publications

(12 citation statements)

References 33 publications

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“…Such inter-colonial variations have previously been reported for Dinoponera quadriceps (Ponerinae) collected from different areas in Brazil (Cologna et al 2013). Among animal venoms, intraspecific variations related to geography are a common phenomenon and have been reported in snakes (Shashidharamurthy et al 2002), cone snails (Duda et al 2009), scorpions (Omran and McVean 2000), spiders (Escoubas et al 1998) and both social ) and parasitoid wasps (Poirié et al 2014). In snakes, intraspecific variations have been shown to exhibit a differential venom effectiveness towards different prey (Casewell et al 2013).…”

Section: Discussionmentioning

confidence: 94%

Intraspecific variations in the venom peptidome of the ant Odontomachus haematodus (Formicidae: Ponerinae) from French Guiana

Touchard¹,

Déjean²,

Escoubas³

et al. 2015

JHR

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Ant venoms are complex cocktails of toxins employed to subdue prey and to protect the colony from predators and microbial pathogens. Although the extent of ant venom peptide diversity remains largely unexplored, previous studies have revealed the presence of numerous bioactive peptides in most stinging ant venoms. We investigated the venom peptidome of the ponerine ant Odontomachus haematodus using LC-MS analysis and then verified whether the division of labor in the colonies and their geographical location are correlated with differences in venom composition. Our results reveal that O. haematodus venom is comprised of 105 small linear peptides. The venom composition does not vary between the different castes (i.e., nurses, foragers and queens), but an intraspecific variation in peptide content was observed, particularly when the colonies are separated by large distances. Geographical variation appears to increase the venom peptide repertoire of this ant species, demonstrating its intraspecific venom plasticity.

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Section: Discussionmentioning

confidence: 94%

Intraspecific variations in the venom peptidome of the ant Odontomachus haematodus (Formicidae: Ponerinae) from French Guiana

Touchard¹,

Déjean²,

Escoubas³

et al. 2015

JHR

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“…Intraspecific venom variation has been previously studied in scorpions [12-15], and extensively in snakes [16,17]. As well as being of interest in the study of the ecology and evolution of venomous animals, this phenomenon is relevant to therapy for scorpion stings and snakebites.…”

Section: Introductionmentioning

confidence: 99%

The Cuban scorpion Rhopalurus junceus (Scorpiones, Buthidae): component variations in venom samples collected in different geographical areas

Rodríguez-Ravelo¹,

Coronas

Zamudio

et al. 2013

Journal of Venomous Animals and Toxins including Tropical Disea

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BackgoundThe venom of the Cuban scorpion Rhopalurus junceus is poorly study from the point of view of their components at molecular level and the functions associated. The purpose of this article was to conduct a proteomic analysis of venom components from scorpions collected in different geographical areas of the country.ResultsVenom from the blue scorpion, as it is called, was collected separately from specimens of five distinct Cuban towns (Moa, La Poa, Limonar, El Chote and Farallones) of the Nipe-Sagua-Baracoa mountain massif and fractionated by high performance liquid chromatography (HPLC); the molecular masses of each fraction were ascertained by mass spectrometry analysis. At least 153 different molecular mass components were identified among the five samples analyzed. Molecular masses varied from 466 to 19755 Da. Scorpion HPLC profiles differed among these different geographical locations and the predominant molecular masses of their components. The most evident differences are in the relative concentration of the venom components. The most abundant components presented molecular weights around 4 kDa, known to be K+-channel specific peptides, and 7 kDa, known to be Na+-channel specific peptides, but with small molecular weight differences. Approximately 30 peptides found in venom samples from the different geographical areas are identical, supporting the idea that they all probably belong to the same species, with some interpopulational variations. Differences were also found in the presence of phospholipase, found in venoms from the Poa area (molecular weights on the order of 14 to 19 kDa). The only ubiquitous enzyme identified in the venoms from all five localities studied (hyaluronidase) presented the same 45 kD molecular mass, identified by gel electrophoresis analysis.ConclusionsThe venom of these scorpions from different geographical areas seem to be similar, and are rich in peptides that have of the same molecular masses of the peptides purified from other scorpions that affect ion-channel functions.

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“…Although it is a standard measure of toxin potency, it is a misleading indicator due to scorpion venom variability (22,26,29,30,38 Scorpion venoms can be classified into two groups according to their molecular sizes, long-chain and short-chain neurotoxins. Among these more studied groups are the short-chain neurotoxins that present 3,000 to 4,400 Da and act on potassium or chloride channels.…”

Section: Venom Analysis By Mass Spectrometry (Lc-esi-hrms) Of [Mh]+ Dmentioning

confidence: 99%

“…In particular, Leiurus quinquestriatus (Ehrenberg, 1928) and Androctonus crassicauda (Olivier, 1807) are recognized as the most poisonous (11,25,44). Also known as the "yellow scorpion" (37) L. quinquestriatus is found in a large desert region spanning Algeria, Mali, Tunisia, Libya, Niger, Chad, Sudan, Ethiopia, Somalia, Egypt, Israel, Jordan, Lebanon, Syria, Turkey, Kuwait, Saudi Arabia, Quatar, United Arab Emirates, Oman and Yemen (5,6,8,13,21,26,35,41,42,45). Likewise, A. crassicauda is a highly relevant species in the Middle East (11,14,18) and is encountered in Azerbaijan, Armenia, southeast Turkey, Syria, Iran, Iraq, Jordan, Israel, Egypt (Sinai Peninsula), Saudi Arabia and Yemen (25,27,33,41,42).…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the neutralizing capacity of Androctonus crassicauda (Olivier, 1807) antivenom against Leiurus quinquestriatus (Ehrenberg, 1928) venom (Scorpiones: Buthidae)

Özkan¹,

Adiguzel²,

Inceoglu³

et al. 2008

J. Venom. Anim. Toxins incl. Trop. Dis

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INTRASPECIFIC VARIATION IN SCORPIONLEIURUS QUINQUESTRIATUSVENOM COLLECTED FROM EGYPT (SINAI AND ASWAN DESERTS)

Cited by 20 publications

References 33 publications

Intraspecific variations in the venom peptidome of the ant Odontomachus haematodus (Formicidae: Ponerinae) from French Guiana

Intraspecific variations in the venom peptidome of the ant Odontomachus haematodus (Formicidae: Ponerinae) from French Guiana

The Cuban scorpion Rhopalurus junceus (Scorpiones, Buthidae): component variations in venom samples collected in different geographical areas

Evaluation of the neutralizing capacity of Androctonus crassicauda (Olivier, 1807) antivenom against Leiurus quinquestriatus (Ehrenberg, 1928) venom (Scorpiones: Buthidae)

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