Intrasession and Between-Visit Variability of Retinal Vessel Density Values Measured with OCT Angiography in Diabetic Patients

Czakó, Cecília; Sándor, Gábor László; Ecsedy, Mónika; Récsán, Zsuzsa; Horváth, Hajnalka; Szepessy, Zsuzsanna; Nagy, Zoltán Zsolt; Kovács, Illés

doi:10.1038/s41598-018-28994-7

Cited by 23 publications

(21 citation statements)

References 44 publications

(35 reference statements)

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“…The control group was rescanned throughout the follow-up to exclude other biasing external factors (repeatability biases). Of note, data regarding the variability of perfusion density and FAZ within a brief time-interval have been reported to have high levels of repeatability and reproducibility, both for healthy subjects and eyes affected by various retinal diseases [28–30]. For further empowered potential follow-up studies, we calculated to include 64 subjects (that might be feasible with size- and center-doubling) to achieve a 30% reduction of effect size with a power of 0.8.…”

Section: Discussionmentioning

confidence: 99%

Reduced perfusion density of superficial retinal capillary plexus after intravitreal ocriplasmin injection for idiopathic vitreomacular traction

et al. 2019

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Background To investigate, using optical coherence tomography angiography (OCT-A), changes in perfusion density and in the foveal avascular zone (FAZ) in eyes with idiopathic vitreomacular traction (VMT) after ocriplasmin injection. Methods In this pilot study, we enrolled sixteen VMT eyes treated with intravitreal ocriplasmin injection. Sixteen healthy eyes were considered as controls. Macular perfusion density in 3 plexuses [superficial capillary plexus (SCP), deep capillary plexus (DCP), choriocapillaris (CC)] was calculated at baseline and at 1 month after injection. Results After injection, VMT anatomically resolved in 9 eyes (56.2%), whereas 7 eyes (43.8%) achieved an incomplete VMT separation. Superficial capillary plexus perfusion density was reduced significantly after injection (from 0.427 ± 0.027 to 0.413 ± 0.028; p = 0.0146), while no differences were noted in the DCP ( p = 0.2717) nor in the CC ( p = 0.6848). Study-eye perfusion density was statistically similar to control eyes in all three plexuses, both at baseline and at follow-up. The FAZ in the SCP area remained unchanged after injection ( p = 0.168) but was significantly inferior to controls both at baseline and at 1 month (0.198 ± 0.074 vs. 0.196 ± 0.070; p = 0.007). Conclusions Eyes with VMT have a perfusion density comparable to healthy controls, but a smaller FAZ. After ocriplasmin injection the perfusion density in the SCP is reduced, regardless the anatomical success. Limited by the small sample size and the pilot nature of the study, we found microvascular changes after ocriplasmin injection, which may be due to retinal traction release.

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Section: Discussionmentioning

confidence: 99%

Reduced perfusion density of superficial retinal capillary plexus after intravitreal ocriplasmin injection for idiopathic vitreomacular traction

et al. 2019

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“…A detailed overview of how different quantitative measures are derived from OCTA is beyond the scope of this review, but the reader is referred to a recent review article [184]. Briefly, although measurements by the same devices using the same processing algorithm may be reliable and reproducible [185][186][187][188], significant variability exists between different devices [189] and image processing methods [186]. Therefore, large population studies of multi-ethnic individuals will need to be collected for each OCTA device, to provide normative data of vascular measures as reference ranges.…”

Section: Limitations Of Optical Coherence Tomography Angiographymentioning

confidence: 99%

Optical Coherence Tomography Angiography in Diabetes and Diabetic Retinopathy

Chua

Sim

Tan

et al. 2020

JCM

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Diabetic retinopathy (DR) is a common complication of diabetes mellitus that disrupts the retinal microvasculature and is a leading cause of vision loss globally. Recently, optical coherence tomography angiography (OCTA) has been developed to image the retinal microvasculature, by generating 3-dimensional images based on the motion contrast of circulating blood cells. OCTA offers numerous benefits over traditional fluorescein angiography in visualizing the retinal vasculature in that it is non-invasive and safer; while its depth-resolved ability makes it possible to visualize the finer capillaries of the retinal capillary plexuses and choriocapillaris. High-quality OCTA images have also enabled the visualization of features associated with DR, including microaneurysms and neovascularization and the quantification of alterations in retinal capillary and choriocapillaris, thereby suggesting a promising role for OCTA as an objective technology for accurate DR classification. Of interest is the potential of OCTA to examine the effect of DR on individual retinal layers, and to detect DR even before it is clinically detectable on fundus examination. We will focus the review on the clinical applicability of OCTA derived quantitative metrics that appear to be clinically relevant to the diagnosis, classification, and management of patients with diabetes or DR. Future studies with longitudinal design of multiethnic multicenter populations, as well as the inclusion of pertinent systemic information that may affect vascular changes, will improve our understanding on the benefit of OCTA biomarkers in the detection and progression of DR.

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“…OCT-A has been found to be a reproducible method to measure retinal vessel density with the automated AngioAnalytics software [22]. OCT-A has been shown to be a valuable tool in the follow up of CNV, after antiVEGF treatment in patients with nAMD but there are only a few reports on the retinal vascular system of nAMD patients [9].…”

Section: Group a Group B Control P (Group A Vs Control) P (Group B Vsmentioning

confidence: 99%

Vascular density in age-related macular degeneration after one year of antiVEGF treatment with treat-and-extend and fixed regimens

et al. 2020

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Treatment of neovascular age-related macular degeneration (nAMD) with VEGF can be performed with several posologies. The purpose of our cross-sectional study was to analyze retinal vessel density by quantitative OCT-angiography (OCT-A) and to compare treat-andextend (T&E) and fixed treatment protocols to a control group with dry AMD. Altogether 48 patients were enrolled: 13 eyes with T&E protocol ranibizumab treatment (group A) and 17 eyes with fixed regimen aflibercept therapy (group B), the control group comprised 18 eyes with dry AMD (group C). One year after the start of the treatment, quantitative OCT-A (AngioVue-Optovue, Fermont, USA) was performed: superficial and deep retinal vessel densities were analyzed in the foveal and parafoveal regions. Our results show, that the density of retinal superficial vasculature in the fovea was not different between the treatment groups (A: 25.9±9.1%; B: 24.3%±8.9), neither from group C (25.6±4.8%). Superficial parafoveal vascular density of the retina, however, was decreased in both treated groups (A: 46.7

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Intrasession and Between-Visit Variability of Retinal Vessel Density Values Measured with OCT Angiography in Diabetic Patients

Cited by 23 publications

References 44 publications

Reduced perfusion density of superficial retinal capillary plexus after intravitreal ocriplasmin injection for idiopathic vitreomacular traction

Reduced perfusion density of superficial retinal capillary plexus after intravitreal ocriplasmin injection for idiopathic vitreomacular traction

Optical Coherence Tomography Angiography in Diabetes and Diabetic Retinopathy

Vascular density in age-related macular degeneration after one year of antiVEGF treatment with treat-and-extend and fixed regimens

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