Intrasellar gangliocytomas associated with acromegaly

Kurosaki, Masamichi; Saeger, Wolfgang; Lüdecke, Dieter K.

doi:10.1007/bf02478929

Cited by 48 publications

(32 citation statements)

References 15 publications

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“…They can be immunostained for synaptophysin, neuron specific enolase, and neurofilament. In acromegaly, GHRH is demonstrable (85,86). In the very rare cases with ACTH hyperfunction, CRH was expressed (87).…”

Section: Pituitary Adenomas In Combination With Neuronal Choristoma (mentioning

confidence: 99%

Pathohistological classification of pituitary tumors: 10 years of experience with the German Pituitary Tumor Registry

Saeger

Lüdecke²,

Buchfelder³

et al. 2007

eur j endocrinol

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523

346

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In 1996, the German Registry of Pituitary Tumors was founded by the Pituitary Section of the German Society of Endocrinology as a reference center for collection and consultant pathohistological studies of pituitary tumors. The experiences of the first 10 years of this registry based on 4122 cases will herein be reported. The data supplement former collections of the years 1970-1995 with 3480 surgically removed tumors or lesions of the pituitary region. The cases were studied using histology, immunostainings and in some cases also molecular pathology or electron microscopy. The adenomas were classified according to the current World Health Organization classification in the version of 2004. From 1996 on 3489 adenomas (84.6%), 5 pituitary carcinomas (0.12%), 133 craniopharyngiomas (3.2%), 39 meningiomas (0.94%), 25 metastases (0.6%), 22 chordomas (0.5%), 115 cystic non-neoplastic lesions (2.8%), and 46 inflammatory lesions (1.1%, 248 other lesions or normal tissue (6.0%)) were collected by us. The adenomas (100%) were classified into densely granulated GH cell adenomas (9.2%), sparsely granulated GH cell adenomas (6.3%), sparsely granulated prolactin (PRL) cell adenomas (8.9%), densely granulated PRL cell adenomas (0.3%), mixed GH/PRL cell adenomas (5.2%), mammosomatotropic adenomas (1.1%), acidophilic stem cell adenomas (0.2%), densely granulated ACTH cell adenomas (7.2%), sparsely granulated ACTH cell adenomas (7.9%), Crooke cell adenomas (0.03%), TSH cell adenomas (1.5%), FSH/LH cell adenomas (24.8%), null cell adenomas (19.3%), null cell adenoma, oncocytic variant (5.8%), and plurihormonal adenomas (1.3%).

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Section: Pituitary Adenomas In Combination With Neuronal Choristoma (mentioning

confidence: 99%

Pathohistological classification of pituitary tumors: 10 years of experience with the German Pituitary Tumor Registry

Saeger

Lüdecke²,

Buchfelder³

et al. 2007

eur j endocrinol

Self Cite

523

346

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“…Our second case is also reported rarely in he literature (3,7,8,13,14,15,18,20,22,23). Gangliocytomas may arise in the hypothalamus immediately adjacent to the pituitary apart from the pituitary itself.…”

Section: Discussionmentioning

confidence: 50%

Ossifying pituitary adenoma co-existing with astrocytoma and gangliocytoma associated with pituitary adenoma. two unusual conditions

Jaiswal¹,

Vij²,

Jaiswal³

et al. 2010

Turkish Neurosurgery

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Bone formation in pituitary adenoma is an extremely rare finding. Only five previous cases have been published. This is the sixth case report of an ossifying pituitary adenoma and the first case report of a pituitary adenoma with bone formation coexisting with WHO grade II astrocytoma. MRI imaging revealed an unusual eggshell cap-like calcified structure surrounding the tumor. Histologically, the adenoma contained irregularly anastomosing trabeculae with well-formed lacunae and osteoblasts along the margins. Our second case concerns a 25-year-old male patient who presented with complains of off and on headache for 12 months. MRI (head) revealed a 4x3cm well defined rounded lesion in the sella and suprasellar extension that was isointense in T1, hyperintense on T2 with cystic areas and homogenous contrast enhancement. On morphological examination, a cellular tumor admixed with foci of large ganglion cells embedded in a neuropil stroma was noted. On immunohistochemistry, tumor cells were focally positive for pancytokeratin, growth hormone and synaptophysin; and ganglion cells were positive for neurofilament and synaptophysin. No GFAP positive cells were seen. The Ki67 index was < 1%. Based on these findings, a diagnosis of gangliocytoma associated with pituitary adenoma was considered.KeywOrds: Pituitary, Pituitary adenoma, Bone formation, Astrocytoma, Gangliocytoma ÖZHipofiz adenomlarında kemik oluşumu oldukça nadir görülen bir bulgudur. Toplam 5 hipofiz adenomu olgusunda kemikleşme oluşumu rapor edilmiştir. Sunulan ilk vaka kemikleşme gösteren hipofiz adenomu olması yanı sıra gonadotropin üreten bir hipofiz adenomu ve grade 2 astrositom ile birlikteliği ile bu özellikteki ilk olgu sunumudur. Manyetik rezonans görüntülemede; kemik dokusunun hipofiz adenomunun etrafını yumurta kabuğu gibi sardığı görüldü. Histolojik olarak adenomanın düzensiz bir şekilde birbiri ile ilişkili trabeküler yapılar yanı sıra; iyi gelişmiş lakünler ve osteoblastları da içerdiği görüldü. Diğer vaka ise 25 yaşında erkek hasta 1 yıldan bu yana ara sıra olan başağrıları nedeni ile çekilen manyetik görüntülemesinde sella ve parasellar bölgede 4x 3 cm'lik iyi sınırlı, oval görünümlü ve T1 kesitlerde isointens, T2 kesitlerde hiperintens görünümün yanı sıra kistik alanlar ve homojen kontrast tutulumu izlendi. Morfolojik incelemede, nöropil doku içerisinde ganglion hücre odakları görüldü. İmmunohistokimya çalışmasında tümör hücrelerinin pansitokeratin, büyüme hormonu ve sinaptofizin ile fokal olarak pozitif reaksiyon verdiği görüldü. Ganglion hücreleri nörofilament ve sinaptofizinle pozitif reaksiyon verdi. GFAP ile tutulum görülmedi. Ki 67 indeksi yüzde 1'in altında idi. Bu bulguların ışığında gangliositoma ile ilişkili hipofiz adenomu olgusu tanısı konulmuştur.

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“…One mechanism, the earliest proposed, suggested that the neuronal lesions, by producing hypothalamic releasing hormones, result in pituitary hyperplasia and promote adenomagenesis [12]. Multiple reports invoked this explanation [11,13,19], and the concept still has its adherents [20]. Demonstration of both the releasing hormone in the gangliocytomas and the respective pituitary hormone in the adenoma lends it support.…”

Section: Discussionmentioning

confidence: 99%

Ganglioglioma of the Neurohypophysis

et al. 2008

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The normal infundibulum and neurohypophysis consist entirely of neuronal processes, the neuronal cell bodies of which lie within the supraoptic and paraventricular nuclei of the hypothalamus and supportive glial cells or pituicytes. The finding of neurons within the neurohypophysis is exceedingly rare, as are ganglion cell tumors at this site. In this paper, we report a ganglion cell tumor of the neurohypophysis found incidentally at autopsy. Despite chronic hypertension and the finding of some vasopressin immunoreactivity in lesional neurons, the syndrome of inappropriate antidiuretic hormone secretion (SIADH) was excluded on the basis of normal serum sodium levels. The morphologic and immunohistochemical features of the tumor are presented, cytogenetic considerations are discussed, and literature regarding neuronal lesions of the pituitary gland is reviewed.

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Intrasellar gangliocytomas associated with acromegaly

Cited by 48 publications

References 15 publications

Pathohistological classification of pituitary tumors: 10 years of experience with the German Pituitary Tumor Registry

Pathohistological classification of pituitary tumors: 10 years of experience with the German Pituitary Tumor Registry

Ossifying pituitary adenoma co-existing with astrocytoma and gangliocytoma associated with pituitary adenoma. two unusual conditions

Ganglioglioma of the Neurohypophysis

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