Intrascrotal paratesticular malignant fibrous histiocytoma-a rare case and its management

Kallianpur, Ashwin A; Kapali, Aravind S; Shukla, N.K.; Deo, S. V. S.; Muduly, Dillip Kumar; Yadav, Richa

doi:10.4103/0019-509x.178381

Cited by 2 publications

(3 citation statements)

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“…UPS may mimic the histopathologic appearance of other sarcomas, e.g., de-differentiated and pleomorphic liposarcoma, pleomorphic leiomyosarcoma. [8,9] Pleomorphic sarcomas have a characteristically ill defined fascicular pattern, cellular and nuclear pleomorphism, bizarre tumor cells with frequent mitoses and necrosis. In our case the other sarcomas were ruled out by the absence of differentiation towards conventional/classical area of liposarcoma, leiomyosarcoma, rhabdomyosarcoma and nerve sheath tumor.…”

Section: Discussionmentioning

confidence: 99%

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Paratesticular Tumors: A Report of Two Rare Cases

M¹,

Jadhav²,

Datar³

et al. 2019

APALM

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Paratesticular tumors are rare comprising 7-10% of total intrascrotal tumors of which 70% are benign and 30% are malignant. Leiomyomas and undifferentiated pleomorphic sarcomas are two such rare paratesticular tumors which should be accurately diagnosed for purpose of treatment and prognosis. We report here two cases. In first case, a 65-year-old man presented with paratesticular mass of 12 years duration. Histology showed features of benign spindle cell tumor. On immunohistochemistry the tumor cells were positive for vimentin, desmin, h-caldesmon and SMA. Based on these findings a diagnosis of leiomyoma of scrotum was made. In second case, a 66-year-old male presented with left paratesticular mass of eight months duration. Histology showed features of high-grade sarcoma. On immunohistochemistry tumor cells were focally positive for SMA and negative for h-caldesmon, desmin, calretinin and ALK-1. A final diagnosis of undifferentiated pleomorphic sarcoma of paratesticular region, grade 3/3 was made.

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Section: Discussionmentioning

confidence: 99%

“…UPS has no specific diagnostic markers, but can show focal positivity for CD68, S100 and vimentin and is a diagnosis of exclusion. [9] Treatment of choice is radical orchidectomy despite which local recurrence has been reported by 51% cases. [10] Both local recurrence and distant metastasis often develop within 12 to 24 months of diagnosis.…”

Section: Discussionmentioning

confidence: 99%

Paratesticular Tumors: A Report of Two Rare Cases

M¹,

Jadhav²,

Datar³

et al. 2019

APALM

View full text Add to dashboard Cite

show abstract

“…It is classified based on lack of any discernable cell lineage, at most sharing characteristics with mesenchymal stem cells and representing the third most common type of sarcoma found in general and the most common radiation-induced sarcoma (RIS) [ 1 – 3 ]. Presentation of sporadic UPS is widely varied in location, as cases have been documented in the stomach [ 4 ], vocal fold [ 5 ], scrotum [ 6 ], and among others. These tumors almost exclusively overlap with areas of radiation exposure in cases of RIS.…”

Section: Introductionmentioning

confidence: 99%

Radiation-Induced Sarcoma following Prolonged Coronary Stent Placement

Vick

Clark

Lewis

2018

Case Reports in Surgery

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Radiation exposure for the average coronary stent placement varies based on a number of factors but typically amounts to 6–11 mSv per patient (compared to 3 mSv background). As with all procedures which utilize radiation, there is an inherent risk of genetic mutation and the possible development of malignancy. Here, we present the case of a 75-year-old male who presented with an exophytic mass on his back following prolonged coronary catheterization with a radiation burn seven years prior. Biopsy of the lesion revealed the mass was consistent with an undifferentiated pleomorphic sarcoma emanating from the site of the radiation burn. After staging studies demonstrated no evidence of metastatic disease, radical excision with negative margins was performed. This case demonstrates that despite the rarity of radiation injury, each incidence necessitates strict monitoring of radiation exposure and continual follow-up due to the risk of malignancy.

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Intrascrotal paratesticular malignant fibrous histiocytoma-a rare case and its management

Cited by 2 publications

References 1 publication

Paratesticular Tumors: A Report of Two Rare Cases

Paratesticular Tumors: A Report of Two Rare Cases

Radiation-Induced Sarcoma following Prolonged Coronary Stent Placement

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