2005
DOI: 10.1167/iovs.05-0694
|View full text |Cite
|
Sign up to set email alerts
|

Intraretinal Oxygen Distribution in the Monkey Retina and the Response to Systemic Hyperoxia

Abstract: In the outer retina of the monkey the P(O2) minimum is lower, and the oxygen consumption rate is higher in the parafoveal region. During systemic hyperoxia, outer retinal oxygen consumption is unaffected, but in the foveal area, total oxygen consumption increases. This regulation of oxygen consumption in the monkey retina is comparable to that reported in lower mammals and may represent an important mechanism in retinal homeostasis.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
3
1

Citation Types

18
132
1

Year Published

2006
2006
2019
2019

Publication Types

Select...
8

Relationship

0
8

Authors

Journals

citations
Cited by 159 publications
(151 citation statements)
references
References 18 publications
18
132
1
Order By: Relevance
“…13 A 60% change in systemic arterial pO 2 corresponded with a 43% change in the choroidal pO 2 measurement, similar to a previous study that measured a 49% change in choroidal pO 2 with oxygen microelectrodes. 32 In the current study, the A-V difference in the retinal circulation also increased with increasing fractions of inspired oxygen, which may be due to autoregulation. It is known that both retinal veins and arteries constrict in response to hyperoxic challenge.…”
Section: Discussionsupporting
confidence: 55%
See 1 more Smart Citation
“…13 A 60% change in systemic arterial pO 2 corresponded with a 43% change in the choroidal pO 2 measurement, similar to a previous study that measured a 49% change in choroidal pO 2 with oxygen microelectrodes. 32 In the current study, the A-V difference in the retinal circulation also increased with increasing fractions of inspired oxygen, which may be due to autoregulation. It is known that both retinal veins and arteries constrict in response to hyperoxic challenge.…”
Section: Discussionsupporting
confidence: 55%
“…When the systemic arterial pO 2 was above 100 mmHg, the choroidal pO 2 was found to be approximately one half of the systemic arterial pO 2 , in agreement with a previous study that used oxygen microelectrodes. 32 With infusion of N ω -NLA, a marked decrease in choroidal pO 2 was demonstrated, which may be attributed to inhibition of the synthesis of NO that maintains a vasodilatory influence on the choroidal vasculature. 16 Previous studies have demonstrated a decrease in choroidal blood flow with intravenously administered systemic inhibitors of NOS.…”
Section: Discussionmentioning
confidence: 96%
“…2) show that pO 2 in the ganglion cell layer of the ex vivo retina increases dramatically from 34 to 548 mm Hg when switching from 21% to 100% O 2 . In contrast, pO 2 in the ganglion cell layer in vivo has been reported to increase only modestly, from ∼21 mm Hg to ∼53 mm Hg, when switching from normoxic to hyperoxic conditions (15). This small increase in O 2 tension within the retina in vivo might not be sufficient to induce the modulatory changes in neurovascular coupling observed in the ex vivo retina.…”
Section: Resultsmentioning
confidence: 94%
“…Electroretinography (11,12) is widely used to study retinal electrical activity and function. Oxygenation and oxygenation changes in the retina have been studied using oxygen electrodes (13,14), phosphores-cence (15), and, more recently, intrinsic optical imaging technique (16 -18). Several methods also exist for measuring blood flow in the retina, including fluorescein angiography (19,20) which can measure retinal circulation and indocyanine-green angiography (21,22) which can measure choroidal circulation in the fovea.…”
mentioning
confidence: 99%