Intrarenal pressure

Miles, Bryan; Wardener, H. E. de

doi:10.1113/jphysiol.1954.sp005038

Cited by 42 publications

(6 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It will be seen that the pressure around the needle is in part a matter of chance: it depends on the quantity and quality of the laceration. It is for this reason, in our opinion, that the measurement of IRP shows such considerable intrinsic variation (17,18). In our hands, the range in normal animals is 10 to 58 ram.…”

Section: Discussionmentioning

confidence: 55%

“…It is for this reason, in our opinion, that the measurement of IRP shows such considerable intrinsic variation (17,18). In our hands, the range in normal animals is 10 to 58 ram.…”

Section: 9mentioning

confidence: 55%

“…Such considerations also readily account for the differences in IRP observed in different sites of the same kidney, in a contraiateral kidney, etc. (8,18).…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Distribution of Blood in the Functional Kidney

Weaver

McCarver

Swann

1956

The Journal of Experimental Medicine

View full text Add to dashboard Cite

It has long been known that the kidney, in its functioning state, is distended with blood (1-4). Rose-Bradford (1) stressed the "passive" character of this distension, for he noted that the kidney swelled when the blood pressure rose and shrank when it fell. Text- fig. 1 shows how the organ collapses when its circulation is abruptly cut off; in this instance, although drainage was obviously incomplete, it shrank from a volume of 49 cc. to a volume of 39 cc., showing that at least 20 per cent of its normal functioning volume was distending fluid. This fluid drains from the renal vein when the renal artery is occluded; in quantity, when drainage is complete, it averages 26 per cent of the functionally distended kidney (5, 6).This aspect of renal behavior has, however, been overlooked by those investigating the functional vascular morphology of the organ. Led recently by Trueta el al. (7), many studies of blood distribution have been attempted, using particularly the technic of injecting India ink into the vascular system and then, at necropsy, examining the distribution of ink. In such studies, the distribution of ink at necropsy should reflect the distribution while the organ is functioning. But if the kidney's blood were to drain out after removal, the subsequent localization of the dye would give only very rough information about the distribution of blood in the functioning organ. The latter is not thoroughly known and hence the present study was undertaken.Actually, the fluid naturally distending the kidney is not blood alone; rather, it is a fluid containing less red cells and less plasma protein than simultaneously drawn blood, the same amount of Na and Ca, and increased quantities of K, C1, urea, and PO4 (6). Because kidney interstitial fluid (or lymph) has approximately this same composition, we have concluded that the distending fluid is very probably a mixture of blood and interstitial fluid. Furthermore, since the distending fluid contains only about half the red cells that blood contains (6), the volume of its two components, in terms of percentage of the functionally distended kidney, is 13 per cent blood and 13 per cent interstitial fluid.

show abstract

Section: Discussionmentioning

confidence: 55%

“…It is for this reason, in our opinion, that the measurement of IRP shows such considerable intrinsic variation (17,18). In our hands, the range in normal animals is 10 to 58 ram.…”

Section: 9mentioning

confidence: 55%

See 1 more Smart Citation

Distribution of Blood in the Functional Kidney

Weaver

McCarver

Swann

1956

The Journal of Experimental Medicine

View full text Add to dashboard Cite

show abstract

“…The deterioration of renal function to a certain amount could be reverted by establishing lower-than-normal air pressure conditions in a chamber surrounding the kidney. The relationship between renal venous and interstitial pressures and its importance in urine production have been studied in detail in the next two studies, subsequent to Winton’s original publication [ 66 , 67 , 68 , 69 , 70 ]. These investigations revealed that urine output starts to decline once renal venous pressure reaches 15–20 mmHg [ 69 ].…”

Section: Venous Drainage and Congestionmentioning

confidence: 99%

Mediators of Regional Kidney Perfusion during Surgical Pneumo-Peritoneum Creation and the Risk of Acute Kidney Injury—A Review of Basic Physiology

Kopitkó

Medve

Gyökeres

et al. 2022

JCM

View full text Add to dashboard Cite

Acute kidney injury (AKI), especially if recurring, represents a risk factor for future chronic kidney disease. In intensive care units, increased intra-abdominal pressure is well-recognized as a significant contributor to AKI. However, the importance of transiently increased intra-abdominal pressures procedures is less commonly appreciated during laparoscopic surgery, the use of which has rapidly increased over the last few decades. Unlike the well-known autoregulation of the renal cortical circulation, medulla perfusion is modulated via partially independent regulatory mechanisms and strongly impacted by changes in venous and lymphatic pressures. In our review paper, we will provide a comprehensive overview of this evolving topic, covering a broad range from basic pathophysiology up to and including current clinical relevance and examples. Key regulators of oxidative stress such as ischemia-reperfusion injury, the activation of inflammatory response and humoral changes interacting with procedural pneumo-peritoneum formation and AKI risk will be recounted. Moreover, we present an in-depth review of the interaction of pneumo-peritoneum formation with general anesthetic agents and animal models of congestive heart failure. A better understanding of the relationship between pneumo-peritoneum formation and renal perfusion will support basic and clinical research, leading to improved clinical care and collaboration among specialists.

show abstract

“…Ludwig et al suggested in the 1860sI that a rise in RVP may indeed lead to a rise in RIP and a decline in GFR. 11 The significance of elevated RIP in response to elevated RVP was discussed further by Winton et al 12 , 13 RIP was assessed through direct measurement by introducing a needle into the renal parenchyma after a hypovolemic state was induced by venesection, which resulted in a fall in renal interstitial pressure. Giving noradrenaline and adrenaline led to an increase in mean arterial pressure but resulted in a decrease in RIP.…”

Section: Forward Versus Backward Failure Hypothesismentioning

confidence: 99%

The Kidney in Heart Failure: The Role of Venous Congestion

Tamayo-Gutierrez¹,

Ibrahim

2022

Methodist DeBakey Cardiovascular Journal

View full text Add to dashboard Cite

Heart failure can lead to renal impairment, an interaction now termed “cardiorenal syndrome.” The prevalent physiological explanation for the renal impairment that accompanies heart failure centers around the forward failure hypothesis, which emphasizes the role of left ventricular dysfunction in causing edema, and the backward failure hypothesis, which singles out venous congestion as the dominant mechanism of edema and reduced glomerular filtration rate. In this review, we provide an appraisal on venous congestion, an extremely important contributor that has received little attention. We also summarize the pharmacology of loop diuretics, explain current understanding of diuretic resistance, and address controversies regarding decongestive treatments.

show abstract

Intrarenal pressure

Cited by 42 publications

References 6 publications

Distribution of Blood in the Functional Kidney

Distribution of Blood in the Functional Kidney

Mediators of Regional Kidney Perfusion during Surgical Pneumo-Peritoneum Creation and the Risk of Acute Kidney Injury—A Review of Basic Physiology

The Kidney in Heart Failure: The Role of Venous Congestion

Contact Info

Product

Resources

About