Intrarenal Blood Flow Distribution in Canine Puppies

José, Pedro A.; Logan, Alexander G.; Slotkoff, Lawrence M.; Lilienfield, Lawrence S.; Calcagno, Philip L.; Eisner, Gilbert M.

doi:10.1203/00006450-197108000-00001

Cited by 83 publications

(37 citation statements)

References 29 publications

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“…As we did not observe any changes in our measurements it is obvious that even longer follow-up with more phases in the intrarenal distribution of RBF would not add any important Information to our results. JOSE et al [9] reported the first flow phase to be about 4.7 ml/g tissue/min in the adult dog. Our fmdings correspond well to these values (Tab.…”

Section: Discussionmentioning

confidence: 99%

“…Isotope technique can be used even in measurements of blood flow of the whole organ [11]. With this method it is possible to measure intrarenal distribution of RBF [9,12]. Our modification in following for four minutes allows measurement of only two phases, whereas ROSEN et al [12], by following the patients during 45 minutes, could distinguish four different phases in RBF.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Renal blood flow in high and low positions of aortal catheter in rabbits

Uhari¹,

Tarkka²,

Koskinen³

1981

Journal of Perinatal Medicine

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Renal blood flow in high and low positions of aortal catheter in rabbits

Uhari¹,

Tarkka²,

Koskinen³

1981

Journal of Perinatal Medicine

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“…The newborn's renal hemodynamic state is characterized by high RVR, which results in low RBF (24)(25)(26). The major factor that causes the newborn's elevated RVR is enhancement of the RAS (2,9,11,27,28).…”

Section: Discussionmentioning

confidence: 99%

Neuronal nitric oxide synthase, nNOS, regulates renal hemodynamics in the postnatal developing piglet

et al. 2011

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“…It has been clearly established that renal growth (10,12,19,20,23) and functional maturation (2,13,14,17,22) proceed centrifugally. This is associated with the development of a progressively more superficial population of nephrons, and presents a potential obstacle to the investigation of maturation at the single nephron level.…”

Section: Discussionmentioning

confidence: 99%

“…Moreover, they are subject to a number of limitations. For instance, clearance measurements are influenced by the developmental changes in the intrarenal distribution of blood flow (2,13,22), which result in alterations in the delivery of substrate to the secreting segments of differing nephron populations; the slice technique detects only the intracellular accumulation of PAH and as a result gives information which corresponds only tenuously to net transepithelial transport (28). In addition, both methods relate transport to the weight of the tissue studied, yet the proximal tubule, the nephron segment responsible for PAH transport, comprises only a finite portion of the cortical or whole kidney mass.…”

Section: Speculationmentioning

confidence: 99%

p-Aminohippurate Transport in the Proximal Straight Tubule: Development and Substrate Stimulation

1978

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Summary pAminohippurate transport by the developing kidney has previously been shown to increase as a function of age and to be enhanced by pretreatment with penicillin. The relative contribution of increases in intrinsic cellular transport capacity and in tubular length was assessed in isolated perfused proximal straight tubules obtained from developing rabbits. The intrinsic capacity for transpurt (10-l5 M/min -mm) increased 4.8-fold (y = -315 + 62.0x, r = 0:69, P < 0.005) from 8-19 days of age. Tubular length (microns) also increased (y = -38.5 + 52.3x, r = 0.84, P < 0.001) during the same period. Nine-to 13-day-old animals pretreated with procaine penicillin (400,000 U) divided over 3 days had an intrinsic capacity for transport of 684 f 88 x 10-l5 M/min mm, which was 89% greater than the 361 f 84 x 10-l5 M/min mm observed in age-matched, untreated controls ( P < 0.02). In these groups tubular length was 630 106 pm and 585 f 37 pm, SpeculationMost of the increase in absolute transport (intrinsic capacity x tubular length) seen with age is the result of the increment in the intrinsic transport capacity, while 33% is a consequence of the rise in the surface area of the transport membrane. Substrate stimulation augments the rate of maturation of the intrinsic transport mechanism without altering the age-related change in the length of the proximal straight tubule.Uptake ofp-aminohippurate (PAH) by renal cortical slices and secretion of this substance by the kidney have been shown to rise during development (7, 11,15, 21,24,25). This may result from increases in intrinsic tubular transport capacity, the ratio of mass of the transporting segments to cortical mass, or both. Pretreatment of young animals with penicillin hastens the increase in uptake or in excretion of PAH, possibly through similar mechanisms (8,9,15). None of the methods thus far used can distinguish between these alternatives. Moreover, they are subject to a number of limitations. For instance, clearance measurements are influenced by the developmental changes in the intrarenal distribution of blood flow (2, 13,22), which result in alterations in the delivery of substrate to the secreting segments of differing nephron populations; the slice technique detects only the intracellular accumulation of PAH and as a result gives information which corresponds only tenuously to net transepithelial transport (28). In addition, both methods relate transport to the weight of the tissue studied, yet the proximal tubule, the nephron segment responsible for PAH transport, comprises only a finite portion of the cortical or whole kidney mass. The isolated perfused tubule does not suffer from these limitations. Furthermore, it enables one to identify and measure the individual contribution made by changes in tubular length and intrinsic capacity to the maturation of the renal trans---of organic anions. MATERIALS A N D METHODSSixteen suckling New Zealand White rabbits, aged 8-19 days, were studied for the changes in PAH transport with age. The effect of substrate s...

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Intrarenal Blood Flow Distribution in Canine Puppies

Cited by 83 publications

References 29 publications

Renal blood flow in high and low positions of aortal catheter in rabbits

Renal blood flow in high and low positions of aortal catheter in rabbits

Neuronal nitric oxide synthase, nNOS, regulates renal hemodynamics in the postnatal developing piglet

p-Aminohippurate Transport in the Proximal Straight Tubule: Development and Substrate Stimulation

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