Intrarater Reliability of Dual-Energy X-Ray Absorptiometry–Based Measures of Vertebral Height in Postmenopausal Women

Bonnyman, Alison; Webber, Colin E.; Stratford, Paul W.; MacIntyre, Norma J.

doi:10.1016/j.jocd.2012.03.005

Cited by 16 publications

(11 citation statements)

References 18 publications

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“…The kappa statistic is a robust measure of agreement between raters that accounts for agreement due to random chance. Kappa values can range from −1 to +1, with 0 representing the amount of agreement expected from random chance and 1 being perfect agreement (McHugh, 2012).…”

Section: Discussionmentioning

confidence: 99%

New developmental syndromes: Understanding the family experience

Inglese

Elliott

Lehman

2019

Journal of Genetic Counseling

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Increased application of next generation sequencing has led to the discovery of a multitude of new neurodevelopmental syndromes, contributing to an increased diagnostic rate for exome sequencing from 25% originally to 40% currently. Owing to the recent recognition of these syndromes, as well as the types of large‐scale studies (with limited phenotype information) often making these discoveries, these disorders may be poorly characterized clinically. As a result there is very limited information and disorder‐specific support available to patients and families. We used a qualitative approach to explore how families experience a diagnosis of a new syndrome. We conducted semi‐structured telephone interviews with parents and adult siblings of children who received a diagnosis of a new syndrome after whole exome sequencing (WES) performed through a translational research study. The interviews were recorded, transcribed verbatim, and transcripts were analyzed using grounded theory methods. Analysis of the 12 interviews revealed that a lack of information about the child's condition continues to play a large role in these families' experiences even after diagnosis. Almost all (92%) participants expressed ongoing uncertainty about their child's health and future. Most (83%) participants were interested in identifying other families with the same syndrome, which was related to both social support and seeking of information. Interestingly, 33% of participants worried about the child's risk for cancer due to their syndrome. Our results highlight some of the needs of families of children with new syndromes, and emphasize important issues care providers should address in pre‐ and post‐test genetic counseling for WES and whole genome sequencing.

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Section: Discussionmentioning

confidence: 99%

New developmental syndromes: Understanding the family experience

Inglese

Elliott

Lehman

2019

Journal of Genetic Counseling

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“…In view of its high NPV, VFA allows selection of patients who will or who will not need Rx for diagnosing VFs [ 17 – 19 , 23 ]. A prevalent VF is a strong predictor of future VFs and non-VFs.…”

Section: Discussionmentioning

confidence: 99%

“…A limitation of the study is the small number of patients with PsA and IBD. Furthermore, we chose only VFs with a deformity >25 % and not smaller deformities, as this would have increased sensitivity but decreased specificity for diagnosing a VF [ 23 ]. Therefore, the prevalence of VFs is even higher in this population when mild deformities are also included [ 14 ].…”

Section: Discussionmentioning

confidence: 99%

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The prevalence of vertebral fractures in spondyloarthritis: relation to disease characteristics, bone mineral density, syndesmophytes and history of back pain and trauma

Geusens¹,

Winter²,

Quaden³

et al. 2015

Arthritis Res Ther

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IntroductionAn increased risk of vertebral fracture (VF) is one of the extra-articular manifestations of spondyloarthropathy (SpA). The prevalence of moderate to severe VFs visualized by radiography (Rx) in patients with SpA in daily practice is unknown until imaging of the full spine is available, as most VFs do not present with clinical signs and symptoms of an acute fracture.MethodsWe evaluated the prevalence of VFs (>25 % loss in height) on available Rx and dual-energy X-ray absorptiometry (DXA) images in 390 consecutive patients with SpA in daily practice. We assessed their association with disease characteristics, bone mineral density, the modified Stoke Ankylosing Spondylitis Spinal Score, and history of trauma.ResultsForty-six patients (11.8 %) had Rx VF (56.4 % men, 93.5 % in the thoracic spine), and 44.5 % had multiple VFs. Compared with patients without VF, patients with VF were older (52.2 vs. 47.3 years, p < 0.01; range 25–84 years), had lower femoral neck T-scores (−1.1 vs. −0.7; p < 0.05), and had a marginally higher modified Stoke Ankylosing Spondylitis Spinal Score (11.7 vs. 7.0; p = 0.06). Among patients with VFs, 15.2 % had a history of trauma with acute back pain (p < 0.001 vs. no VF). The reliability of DXA for diagnosing radiographic VFs was high (κ 0.90).ConclusionsModerate to severe VFs are found in more than 10 % of patients with SpA before the age of 40 years in 5 % of women and 9 % in men. Most VFs are located in the thoracic region, are related to low femoral neck bone mineral density and to stiffening of the spine, and are only rarely related to trauma history. DXA is a useful alternative for diagnosing VFs.

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“…In Study I, following the PRISMA guidelines 85 139 . However, studies using only one rater have also shown discrepancies when the rater is introduced to exactly the same situation more than once 140 . We did not perform test-retests on agreement (Study III and IV).…”

Section: Reliabilitymentioning

confidence: 99%