Intrapulmonary unicentric Castleman disease mimicking peripheral pulmonary malignancy

Abstract

Castleman disease, also known as angiofollicular lymph node hyperplasia, can manifest as a unicentric or multicentric disorder. Intrapulmonary Castleman disease is very rare. Here, we present a patient with intrapulmonary Castleman disease who underwent left upper pulmonary lobectomy for suspected early lung cancer. The histopathologic diagnosis of the lobar mass was hyaline-type Castleman disease. The patient has remained well after surgery, showing no local recurrence or distant disease during a two-year follow-up period. Although unicentric Castleman disease originating in the lung is rare, it should be considered in the differential diagnosis of primary pulmonary malignant tumors.

Hyaline Vascular Type of Unicentric Castleman Disease in a Kidney with End-Stage Renal Disease: A Case Report of a Rare Entity at an Unusual Location and a Special Clinical Setting

“…CD has been diagnosed within variable primary sites, including the mediastinal, intra-abdominal, cervical, axillary, retroperitoneal or inguinal lymph nodes [ 7 , 15 ]. Rarely, UCD presents in unusual sites, such as the lungs, orbits, mouth, tonsil, nasopharynx, liver and small intestine [ 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 ]. Single-site involvement of renal parenchyma is extremely rare in this disease, with only a little relevant literature published.…”

Tumor enucleation for Castleman’s disease in the pulmonary hilum: a case report

“…Therefore, the recommended treatment strategy for localized HV type CD is complete resection. We found ten cases of resection of HV type CD in the pulmonary hilum in which detailed clinical information including surgical procedure could be obtained from the articles searched with the terms: Castleman’s disease AND pulmonary AND surgery in PubMed (Table 1) [9–11, 13–19]. One case reported by Luo et al was described as “whole resection” and the details were unknown about surgical procedure [11].…”

“…In only one of seven cases was intraoperative frozen section diagnosis performed [10]. In three of six cases, lobectomy was performed because malignancy of the tumor could not be ruled out [13, 14, 19]. Moreover, in the other case, there was no mention in the article why lobectomy was performed [17].…”