Intrapulmonary neurogenic tumors

Bartley, Thomas D.; Arean, Victor M.

doi:10.1016/s0022-5223(19)33242-8

Cited by 59 publications

(20 citation statements)

References 15 publications

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“…With the introduction of immunohistochemistry came the accurate characterization and subclassification of both soft tissue neoplasms and their counterparts in the lung, allowing issues relating to the biological behaviour of individual tumour types to be addressed. In soft tissues the existence of malignant fibrous histiocytoma (MFH) as a discrete entity has been questioned by some authors 14 although in the lung, published series would suggest that few authors share that opinion and indeed some publications suggest that MFH is the most common primary sarcoma of the lung 9 . By use of strict morphological criteria and immunophenotyping all the tumours were better classified as types of sarcoma other than MFH.…”

Section: Discussionmentioning

confidence: 99%

Primary sarcomas of the lung: a clinicopathological and immunohistochemical study of 14 cases

1996

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The clinicopathological features and immunohistochemical findings in 14 primary sarcomas of the lung collected over a 30-year-period are presented. This represents one sarcoma per 550 bronchogenic carcinomas undergoing resection in this centre. The study group comprised six leiomyosarcomas, five malignant peripheral nerve sheath tumours, two haemangiopericytomas and one epithelioid haemangioendothelioma. The majority of cases occurred in men (nine males: five females), with mean age at presentation of 54 years for men and 47 years for women. All leiomyosarcomas were seen in men, whereas malignant peripheral nerve sheath tumours showed no particular sex preponderance. Leiomyosarcomas were larger tumours than malignant peripheral nerve sheath tumours, mean tumour diameter 15 cm (range 10-25 cm) compared to 9.5 cm (7-15 cm), respectively. All leiomyosarcomas were situated intraparenchymally whereas two of the five malignant peripheral nerve sheath tumours were endobronchial in site. Extrathoracic metastates were seen at death in two of the six leiomyosarcomas but not in any of the malignant peripheral nerve sheath tumours. Overall survival was 28 months although for the leiomyosarcoma/malignant peripheral nerve sheath tumour group alone survival was 8 months. Tumour grading appeared to be a more useful prognostic factor than tumour site (endobronchial/parenchymal) or tumour size. Haemangiopericytoma and epithelioid haemangioendothelioma were associated with a more favourable prognosis.

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Section: Discussionmentioning

confidence: 99%

Primary sarcomas of the lung: a clinicopathological and immunohistochemical study of 14 cases

1996

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“… 3 Most intrapulmonary neurogenic tumors were neurofibromas, with schwannomas accounting for 25% of the tumors. 9 …”

Section: Discussionmentioning

confidence: 99%

Bilateral benign endobronchial schwannomas

Bircan

Kapucuoğlu

Öztürk

et al. 2007

Annals of Saudi Medicine

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“…A minority of primary intrapulmonary nerve sheath tumors have arisen in association with NF1. MPNSTs arising primarily within the lung are even rarer than their benign counterparts [14,17,18]. In their review of the literature, Bartley and Arean [17] found only 32 examples of intrapulmonary tumors of nerve sheath origin, only 7 of which were malignant, no association with NF1 was mentioned.…”

Section: Discussionmentioning

confidence: 99%

Primary malignant peripheral nerve sheath tumor of the lung in a young child without neurofibromatosis type 1

Muwakkit

Rodríguez‐Galindo

Samra

et al. 2006

Pediatric Blood & Cancer

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Malignant peripheral nerve sheath tumors (MPNST) are uncommon in children and almost half of the cases occur in patients with neurofibromatosis 1 (NF1). We report a child with a primary MPNST of the lung without NF1. MPNST of the lung has similar clinical and radiologic characteristics as pleuropulmonary blastoma. We suggest to include MPNST of the lung in the differential diagnosis of intrapulmonary masses in children.

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Intrapulmonary neurogenic tumors

Cited by 59 publications

References 15 publications

Primary sarcomas of the lung: a clinicopathological and immunohistochemical study of 14 cases

Primary sarcomas of the lung: a clinicopathological and immunohistochemical study of 14 cases

Bilateral benign endobronchial schwannomas

Primary malignant peripheral nerve sheath tumor of the lung in a young child without neurofibromatosis type 1

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