Intraprostatic vasopressin before TURP

Sharma, D.

doi:10.1111/j.1464-410x.1995.tb07721.x

Cited by 6 publications

(4 citation statements)

References 1 publication

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“…We use intraprostatic vasopressin (IPVP) for resecting the largest prostates; IPVP considerably reduces blood loss and we almost never need to use a blood transfusion [5]. IPVP also reduces irrigant absorption, thus permitting the safe use of cheap boiled water as the TURP irrigant.…”

Section: Introductionmentioning

confidence: 99%

The management of benign prostatic obstruction: a voice from the Third World

Sharma

2006

BJU International

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Section: Introductionmentioning

confidence: 99%

The management of benign prostatic obstruction: a voice from the Third World

Sharma

2006

BJU International

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“…We reported the use of intraprostatic vasopressin (IPVP) during TURP in 1995 [6]. The presumption was that vasopressin constricts the prostatic blood vessels and thus reduces bleeding.…”

Section: Introductionmentioning

confidence: 99%

Does intraprostatic vasopressin prevent the transurethral resection syndrome?

Sharma¹,

Harvey²

2000

BJU International

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Objective To determine whether intraprostatic vasopressin (IPVP) prevents the transurethral resection (TUR) syndrome during prostatectomy. Patients and methods The study comprised 36 consecutive patients (mean age 68 years) with prostates clinically assessed as o 20 g who underwent standard transurethral prostatectomy (TURP). Ten units of vasopressin in 0.5 mL were diluted with 9.5 mL isotonic saline and injected into the prostate transrectally before TURP. Blood samples were taken before and immediately after TURP to measure serum sodium concentration and free haemoglobin levels. The TURP irrigant used was cooled, boiled water maintained at 70±80 cmH 2 O pressure during resection. Twenty patients had alcohol added to the irrigant and their breath alcohol assessed at 10-min intervals during TURP. All patients had their pulse rate, blood pressure and sensorium monitored continuously. Extreme care was taken to avoid and/or identify capsular damage during resection. Results The mean weight of tissue resected was 36 g and the mean resection time 24 min. There was no signi®cant change in clinical variables during TURP. In 19 patients the breath alcohol changes were insigni®cant. Changes in free haemoglobin were not signi®cant, but the levels decreased after TURP in four patients, caused by the dilution consequent on the infusion of 800±1000 mL isotonic saline during surgery. Serum sodium concentrations showed only insigni®cant decreases, except in one patient whose breath alcohol suggested the absorption of 500 mL of irrigant. This patient's serum sodium concentration decreased by 9 mmol/L; 1 L of 5% dextrose was infused during the procedure and capsular damage was recognized early during TURP. Conclusion Insigni®cant volumes of irrigant entered the circulation of the patients during TURP with water irrigation and IPVP. The greatest risk factor for¯uid entry during TURP is capsular damage. IPVP decreases bleeding and therefore improves visibility, so allowing the early identi®cation of capsular damage. IPVP seems therefore to be of help during TURP by decreasing bleeding and allowing insignificant volumes of irrigant to enter the vasoconstricted vessels; it appears to prevent the TUR syndrome.

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“…We use an intraprostatic injection to vasoconstrict the prostatic vessels during TURP. We hypothesised that vaso‐constricted intraprostatic vessels would bleed less, and tested this with a study published in 1995 [2] and with a follow‐up in 2000 [3]. Initially we expected that multiple injections would be required.…”

mentioning

confidence: 99%

Diffusion properties of transurethral intraprostatic injections

Sharma¹

2005

BJU International

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Intraprostatic vasopressin before TURP

Cited by 6 publications

References 1 publication

The management of benign prostatic obstruction: a voice from the Third World

The management of benign prostatic obstruction: a voice from the Third World

Does intraprostatic vasopressin prevent the transurethral resection syndrome?

Diffusion properties of transurethral intraprostatic injections

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