Intraprocedural contrast-enhanced ultrasound-CT/MR fusion imaging assessment in HCC thermal ablation to reduce local tumor progression: compared with routine contrast-enhanced ultrasound

Ju, Jinxiu; Zeng, Qingjing; Xu, Erjiao; He, Xiaofeng; Tan, Lei; Huang, Qiannan; Li, Kai; Zheng, Rongqin

doi:10.1080/02656736.2019.1640899

Cited by 16 publications

(29 citation statements)

References 43 publications

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“…Expanding or overlapping ablation was performed to ensure that all the tumors were ablated at least 0.5 cm beyond the tumor margin when possible [25,26]. Artificial ascites were created before RFA which acted as an insulation layer between the tumor(s) and the adjacent vital structures such as gallbladder, diaphragm, pericardium, liver capsule and gastrointestinal tract [24,27,28]. After the lesions were ablated, the ablation path was cauterized to avoid tumor seeding and hemorrhage.…”

Section: Rfa Proceduresmentioning

confidence: 99%

Early recurrence after radiofrequency ablation for hepatocellular carcinoma: a multicenter retrospective study on definition, patterns and risk factors

Yang

Xin

et al. 2021

International Journal of Hyperthermia

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Objective: To define an optimal cutoff time to distinguish early and late recurrence in hepatocellular carcinoma (HCC) patients after radiofrequency ablation (RFA), and to determine the risk factors and patterns of early recurrence. Materials and methods: This retrospective study included HCC patients who developed recurrence after RFA as the primary therapy at three Chinese hospitals from January 2011 to December 2016. The best cutoff time to define early and late recurrence was determined based on differences in post recurrence survival (PRS). The clinical variables were assessed by univariate and multivariate logistic regression analyses. Results: A total of 279 eligible patients were included. The optimal cutoff time interval after RFA to differentiate early and late recurrence was identified as 12 months (p ¼ 0.029). The independent risk factors of early recurrence were multiple tumors, alpha fetoprotein (AFP) levels, gamma-glutamyl transferase (c-GT), and serum albumin (ALB) levels. A well-discriminated nomogram was constructed to predict risk of early recurrence. The incidence of intrahepatic distant recurrence (IDR) alone and IDR þ extrahepatic recurrence (ER) in early recurrence group was significantly higher than those in late recurrence group (80.73% vs. 66.47%, p ¼ 0.009). Conclusion: Twelve months was determined as the optimal cutoff time for differentiating early and late recurrence after RFA for HCC patients. The factors affecting early recurrence after RFA were multiple tumors, AFP levels, ALB level, and c-GT level. Patients in early recurrence cohort were more likely to develop IDR alone or IDR þ ER.

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Section: Rfa Proceduresmentioning

confidence: 99%

Early recurrence after radiofrequency ablation for hepatocellular carcinoma: a multicenter retrospective study on definition, patterns and risk factors

Yang

Xin

et al. 2021

International Journal of Hyperthermia

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“…Consequently, some assisted methods were adopted to achieve complete ablation (21,22). In recent years, many studies have confirmed that the ablation margin is closely related to local recurrence (23,24). Thus, evaluation of the ablation margin becomes more and more important in the clinical treatment of HCC.…”

Section: Discussionmentioning

confidence: 99%

A novel mono-modality fusion imaging method based on three-dimensional contrast-enhanced ultrasound for the evaluation of ablation margins after microwave ablation of hepatocellular carcinoma

Jing¹,

Wang²,

Zhou³

et al. 2021

J Gastrointest Oncol

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Background: To investigate the feasibility and accuracy of using preoperative and postoperative threedimensional contrast-enhanced ultrasound (3D CEUS) fusion imaging in the evaluation of safety margins after thermal ablation of hepatocellular carcinoma (HCC). Methods: A total of the 24 patients with HCC who underwent microwave ablation (MWA) between June 2020 and December 2020 were enrolled in this study. All patients received preoperative and postoperative 3D CEUS. The preoperative and postoperative 3D CEUS images were then fused. The success rate and evaluation time were recorded. The ablation margin and whether or not the safety margin was reached were calculated and recorded. If the ablation safety margin was not reached, the residual ablation volume needed to cover the safety margin was calculated automatically. The agreement between contrast-enhanced computed tomography(CECT) and 3D CEUS fusion imaging in the evaluation of ablation margins was explored using the kappa coefficient.Results: The 3D CEUS fusion success rate was 95.8% (23/24), with a mean fusion time of (4.1±1.8) minutes. Twenty-three tumors were completely ablated, and the safety margin was achieved for 9 tumors. The ablation margin of 14 tumors was <5 mm. The mean uncovered safety margin volume was (2.27±2.11) mL, and the mean proportion of the uncovered safety margin to the whole safety margin was 16.8%. According to the results of preoperative and postoperative CECT fusion imaging, the ablation margin of 13 tumors was <5 mm, and the ablation margin of 10 tumors was >5 mm. The 2 methods showed excellent consistency, with a Kappa value of 0.911 (P=0.000012). Conclusions: This study has presented a novel mono-modality fusion imaging method based on CEUS.We demonstrated that 3D CEUS fusion has a short fusion time and a high success rate, as well as good consistency with enhanced CT fusion. Therefore, 3D CEUS fusion is a feasible and accurate tool for evaluating the immediate efficacy of thermal ablation of HCC.

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“…The incidence of liver cancer is associated with hepatitis B and c virus infection, aflatoxin, drinking water pollution, alcohol, liver cirrhosis, sex hormones, nitrosamines and trace elements (24)(25)(26). However, the pathogenesis and treatment of liver cancer is still unclear (27,28). Therefore, it is of great significance to study the regulatory mechanism of liver cancer tumorigenesis.…”

Section: Discussionmentioning

confidence: 99%

LncRNA BCAR4 promotes liver cancer progression by upregulating ANAPC11 expression through sponging miR‑1261

Zhou

2020

Int J Mol Med

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Liver cancer is a malignant tumor that occurs in the liver and can be divided into primary and secondary liver cancer. Long non-coding RNA (lncRNA) breast cancer anti-estrogen resistance 4 (BcAR4) has been demonstrated to promote the development of various types of cancer. However, the function of lncRNA BcAR4 in liver cancer remains unclear. In the present study, the expression of lncRNA BcAR4 was notably elevated in liver cancer compared with adjacent non-tumor tissues. Functional in vitro assays demonstrated that knockdown of lncRNA BcAR4 inhibited the proliferation, migration and invasion of Huh-7 cells. In addition, lncRNA BcAR4 was demonstrated to directly bind to microRNA (miR)-1261, and miR-1261 expression negatively correlated with the expression of lncRNA BcAR4. Through bioinformatics analysis, lncRNA BcAR4 was predicted to target anaphase-promoting complex subunit 11 (ANAPc11) through miR-1261. In addition, the results demonstrated that lncRNA BcAR4 increased the expression of ANAPc11 by inhibiting miR-1261 expression. consistently, overexpression of ANAPc11 or inhibition of miR-1261 significantly rescued liver cancer cell proliferation induced by knockdown of lncRNA BcAR4. collectively, the results of the present study demonstrated that lncRNA BcAR4 may promote liver cancer development by directly binding to miR-1261 and targeting ANAPc11.

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Intraprocedural contrast-enhanced ultrasound-CT/MR fusion imaging assessment in HCC thermal ablation to reduce local tumor progression: compared with routine contrast-enhanced ultrasound

Cited by 16 publications

References 43 publications

Early recurrence after radiofrequency ablation for hepatocellular carcinoma: a multicenter retrospective study on definition, patterns and risk factors

Early recurrence after radiofrequency ablation for hepatocellular carcinoma: a multicenter retrospective study on definition, patterns and risk factors

A novel mono-modality fusion imaging method based on three-dimensional contrast-enhanced ultrasound for the evaluation of ablation margins after microwave ablation of hepatocellular carcinoma

LncRNA BCAR4 promotes liver cancer progression by upregulating ANAPC11 expression through sponging miR‑1261

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