Intrapleural Fibrinolytic Interventions for Retained Hemothoraces in Rabbits
Christian J. De Vera,
Jincy Jacob,
Krishna Sarva
et al.
Abstract:Bleeding within the pleural space may result in persistent clot formation called retained hemothorax (RH). RH is prone to organization, which compromises effective drainage, leading to lung restriction and dyspnea. Intrapleural fibrinolytic therapy is used to clear the persistent organizing clot in lieu of surgery, but fibrinolysin selection, delivery strategies, and dosing have yet to be identified. We used a recently established rabbit model of RH to test whether intrapleural delivery of single-chain urokina… Show more
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