Intraperitoneal photodynamic therapy mediated by a fullerene in a mouse model of abdominal dissemination of colon adenocarcinoma

Mróz, Paweł; Xia, Yumin; Asanuma, Daisuke; Konopko, Aaron M.; Zhiyentayev, Timur; Huang, Ying‐Ying; Sharma, Sunil; Dai, Tianhong; Khan, Usman; Wharton, Tim; Hamblin, Michael R.

doi:10.1016/j.nano.2011.04.007

Cited by 65 publications

(31 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Pristine fullerenes are insoluble in water, but the cage can be readily functionalized with polar groups such as carboxylic acids and quaternary amino groups that improve solubility and biological compatibility. Fullerenes have been used to mediate PDT of cancer cells [93] and microbial cells [94] in vitro , to treat tumours [95] and infections [96] in vivo , and there is even one case report of a clinical application.…”

Section: Nanotechnologymentioning

confidence: 99%

New photosensitizers for photodynamic therapy

Abrahamse

Hamblin

2016

Biochemical Journal

1,600

1,172

View full text Add to dashboard Cite

Photodynamic therapy (PDT) was discovered more than 100 years ago, and has since become a well-studied therapy for cancer and various non-malignant diseases including infections. PDT uses photosensitizers (PSs, non-toxic dyes) that are activated by absorption of visible light to initially form the excited singlet state, followed by transition to the long-lived excited triplet state. This triplet state can undergo photochemical reactions in the presence of oxygen to form reactive oxygen species (including singlet oxygen) that can destroy cancer cells, pathogenic microbes and unwanted tissue. The dual-specificity of PDT relies on accumulation of the PS in diseased tissue and also on localized light delivery. Tetrapyrrole structures such as porphyrins, chlorins, bacteriochlorins and phthalocyanines with appropriate functionalization have been widely investigated in PDT, and several compounds have received clinical approval. Other molecular structures including the synthetic dyes classes as phenothiazinium, squaraine and BODIPY (boron-dipyrromethene), transition metal complexes, and natural products such as hypericin, riboflavin and curcumin have been investigated. Targeted PDT uses PSs conjugated to antibodies, peptides, proteins and other ligands with specific cellular receptors. Nanotechnology has made a significant contribution to PDT, giving rise to approaches such as nanoparticle delivery, fullerene-based PSs, titania photocatalysis, and the use of upconverting nanoparticles to increase light penetration into tissue. Future directions include photochemical internalization, genetically encoded protein PSs, theranostics, two-photon absorption PDT, and sonodynamic therapy using ultrasound.

show abstract

Section: Nanotechnologymentioning

confidence: 99%

New photosensitizers for photodynamic therapy

Abrahamse

Hamblin

2016

Biochemical Journal

1,600

1,172

View full text Add to dashboard Cite

show abstract

“…We have also recently shown 102 the therapeutic effects of intraperitoneal PDT with fullerene and white light in a very challenging mouse model of disseminated abdominal cancer. In this study we prepared the monocationic BF4 (Fig.…”

Section: Anticancer Effect Of Fullerene-pdtmentioning

confidence: 99%

“…(B) Quantitative analysis of bioluminescence dynamics in control and white light treated mice ( n = 10 per group). Reprinted with permission from [102], P. Mroz, et al, Intraperitoneal photodynamic therapy mediated by a fullerene in a mouse model of abdominal dissemination of colon adenocarcinoma. Nanomedicine 7, 965 (2011).…”

Section: Figurementioning

confidence: 99%

Functionalized Fullerenes in Photodynamic Therapy

Huang¹,

Sharma²,

Yin³

et al. 2014

j biomed nanotechnol

Self Cite

110

View full text Add to dashboard Cite

Since the discovery of C60 fullerene in 1985, scientists have been searching for biomedical applications of this most fascinating of molecules. The unique photophysical and photochemical properties of C60 suggested that the molecule would function well as a photosensitizer in photodynamic therapy (PDT). PDT uses the combination of non-toxic dyes and harmless visible light to produce reactive oxygen species that kill unwanted cells. However the extreme insolubility and hydrophobicity of pristine C60, mandated that the cage be functionalized with chemical groups that provided water solubility and biological targeting ability. It has been found that cationic quaternary ammonium groups provide both these features, and this review covers work on the use of cationic fullerenes to mediate destruction of cancer cells and pathogenic microorganisms in vitro and describes the treatment of tumors and microbial infections in mouse models. The design, synthesis, and use of simple pyrrolidinium salts, more complex decacationic chains, and light-harvesting antennae that can be attached to C60, C70 and C84 cages are covered. In the case of bacterial wound infections mice can be saved from certain death by fullerene-mediated PDT.

show abstract

“…Such particles were demonstrated for IP PDT using a colon adenocarcinoma mouse model. 138 Fullerenes have also shown efficacy as PS by both intravenous injection and local exposure against fibrosarcoma and bacterial infection. 139,140 …”

Section: Nanotechnology In Therapeuticsmentioning

confidence: 99%

Development of Nanoscale Approaches for Ovarian Cancer Therapeutics and Diagnostics

2014

View full text Add to dashboard Cite

Ovarian cancer is the deadliest of all gynecological cancers and the fifth leading cause of death due to cancer in women. This is largely due to late-stage diagnosis, poor prognosis related to advanced-stage disease, and the high recurrence rate associated with development of chemoresistance. Survival statistics have not improved significantly over the last three decades, highlighting the fact that improved therapeutic strategies and early detection require substantial improvements. Here, we review and highlight nanotechnology-based approaches that seek to address this need. The success of Doxil, a PEGylated liposomal nanoencapsulation of doxorubicin, which was approved by the FDA for use on recurrent ovarian cancer, has paved the way for the current wave of nanoparticle formulations in drug discovery and clinical trials. We discuss and summarize new nanoformulations that are currently moving into clinical trials and highlight novel nanotherapeutic strategies that have shown promising results in preclinical in vivo studies. Further, the potential for nanomaterials in diagnostic imaging techniques and the ability to leverage nanotechnology for early detection of ovarian cancer are also discussed.

show abstract

Intraperitoneal photodynamic therapy mediated by a fullerene in a mouse model of abdominal dissemination of colon adenocarcinoma

Cited by 65 publications

References 43 publications

New photosensitizers for photodynamic therapy

New photosensitizers for photodynamic therapy

Functionalized Fullerenes in Photodynamic Therapy

Development of Nanoscale Approaches for Ovarian Cancer Therapeutics and Diagnostics

Contact Info

Product

Resources

About