Intraperitoneal Injections of Carbohydrates to Suckling Rats, and Subsequent Dental Caries

The systemic influence of carbohydrates on teeth

“…Alloxan diabetes increases caries incidence in mature rats given a cariogenic diet (Hartles & Lawton, 1958;Sweeney, Shaw & Rubin, 1962), and intraperitoneal injections of sugar solutions have a similar effect (Steinman & Hardinge, 1958). These observations would support the claim made by Steinman (1962) that 'resistance to decay is metabolic as well as structural.'…”

“…T h e absence of adequate controls reduces the significance of this study and also of two additional studies, which, at first sight, seemed to clarify the situation. When intraperitoneal injections of a sugar solution were given to suckling rats, the subsequent increase in caries was similar to that caused by oral administration (Steinman, Haley & O'Day, 1958). This result suggests a direct systemic action of sugar solutions and eliminates Vol.…”

“…This study was incomplete as it did not include a group of animals given sucrose throughout the suckling period, and thus we cannot decide if the effects of sucrose in each of the three periods would be additive. There is at least evidence to suggest that the concentration of sucrose in artificial feeds given to suckling rats is directly related to the subsequent caries scores (Steinman & Haley, 1958). It has been claimed that carbohydrates, acting during tooth development, vary in their ability to alter caries resistance (Steinman & Haley, 1957aO'Day & Haley, 1959), but the inadequacy of experimental data and the lack of satisfactory control studies and statistical treatment prevent us from grading the different carbohydrates studied by Steinman and his associates.…”

Τεχνικές Αποκατάστασης Τερηδόνων Ρίζας

“…8 Οι υδατάνθρακες επιδρούν ακόμα από το στάδιο της διάπλασης και ενασβεστίωσης του δοντιού και μεταβάλλουν τη χημική σύσταση των δοντιών δημιουργώντας έτσι δόντια πιο ευαίσθητα στην τερηδόνα. 9 Η δράση πάντως των υδατανθράκων βασικά είναι τοπική μετά την ανατολή των δοντιών και εντοπίζεται στις οδοντικές επιφάνειες που έρχονται σε άμεση επαφή με αυτούς. 10 Το πόσο τερηδονογόνοι είναι, εξαρτάται από τους εξής παράγοντες: α) Από το ζυμώσιμο ή όχι: οι υδατάνθρακες σαν ουσίες δεν επιδρούν πάνω στην αδαμαντίνη όπως είναι, αλλά μέσω της διάσπασης τους σε οξέα δημιουργούν περι βάλλον χαμηλού pH, το οποίο προκαλεί την αποδόμηση του ανόργανου μέρους των ιστών.…”