Intraperitoneal hyperthermic treatment for peritoneal dissemination of colorectal cancers

Abstract

Continuous hyperthermic peritoneal perfusion (CHPP) combined with administration of anticancer drugs was performed in eight colorectal cancer patients with peritoneal dissemination. An overall response rate of 50 percent was achieved in the eight patients. Two of three complete responders are long, recurrence-free survivors for 15 and 30 months. The two-year survival has been achieved in 18.8 percent of the patients receiving CHPP, and this rate is significantly higher than the rates in P2 and P3 patients who did not receive CHPP. The complications of CHPP with administration of anticancer drugs were mild bone marrow suppression in two (25 percent) of the eight patients and also a mild grade of renal dysfunction in one (12.5 percent), though not lethal. The results suggest that the combination of CHPP with the administration of anticancer drugs is a safe and effective therapy for peritoneal dissemination of colorectal cancers.

Effect of the combination of hyperthermia and irradiation on human colon cancer cells

“…Both modalities might be used for colorectal cancer [20,21]. In conclusion: (1) the combined treatment with radiation and hyperthermia proved to be more effective on colon cancer cells than singular therapeutic approaches, and (2) radiation followed by heat can provide more satisfactory therapeutic results than the reverse order.…”

Intraperitoneal heated chemotherapy affects healing of experimental colonic anastomosis: An animal study

“…Cytoreduction has been reported for a variety of cancers; ovary [6], colorectal [1,8,11,18], gastric [2,4,7,14], sarcoma [12], and pseudomyxoma [10], with promising results. The procedure is accompanied by morbidity and mortality associated with anastomotic complications such as leakage, abscess, and fistula formation.…”

“…Heated (41-428C) high dose chemotherapy is then administered during the operative procedure and the early postoperative period in order to eliminate minimal residual disease: the most commonly used drugs being mitomycin C (MMC) or cisplatinum [10,18]. This is an aggressive surgical procedure involving major bowel resection and anastomoses.…”

Efficacy and Safety of Intraoperative Peritoneal Hyperthermic Chemotherapy for Advanced Gastric Cancer Patients with Serosal Invasion

“…Some reports suggest that postoperative complications, including anastomotic leakage, bowel perforation, renal dysfunction, respiratory failure, and other complications occurred more frequently when IPHC was applied [35,36,37,38,39], while others claim IPHC is safe [7, 8, 10, 12, 13, 30,40,41,42]. In our modality, there were no surgery or IPHC-related deaths, and renal dysfunction seemed to be the only meaningful complication.…”