Intraperitoneal Erythropoietin

Frenken, L.A.M.; Coppens, P.J.W.; Tiggeler, R.G.W.L.; Koene, R.A.P.

doi:10.1016/s0140-6736(89)92544-0

Cited by 4 publications

(4 citation statements)

References 2 publications

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“…Larger doses are needed if erythropoietin is applied intraperitoneally. Frenken et al used a maintenance dose of 216 units/kg per week in adult patients [6], whereas our study needed 279 units/kg per week in children after 1 year of treatment. The time from start of treatment to achievement of target range was about 9 months in our study (see Fig.…”

Section: Discussionmentioning

confidence: 78%

“…For children treated by CAPD, intraperitoneal administration may be considered and has been advocated in the literature [6]. The amount of absorption of erythropoietin is, however, a point of discussion.…”

Section: Discussionmentioning

confidence: 99%

“…In humans only a very limited absorption was observed [4,12,13]. Controversial results were obtained in therapeutic studies with intraperitoneal erythropoietin [6,9,10,12].…”

Section: Discussionmentioning

confidence: 99%

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Intraperitoneal administration of recombinant human erythropoietin in children on continuous ambulatory peritoneal dialysis

1992

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In 16 children treated by continuous ambulatory peritoneal dialysis (CAPD) recombinant human erythropoietin was administered intraperitoneally for the treatment of renal anaemia. The mean treatment period was 8.3 months. Mean haemoglobin values increased from 4.9 mmol/l at start of therapy to 6.2 after 6 months. While 11 out of 16 children needed a total of 22 transfusions during the 6 months prior to therapy, no transfusions were needed after initiation of therapy. Patients started with a dose of 300 units/kg per week. After 6 months of therapy, the mean dose was 370 and after 12 months 279 units/kg per week. No major side-effects were observed. The incidence of peritonitis was not increased. We conclude that intraperitoneal administration of erythropoietin is effective in the treatment of renal anaemia in children treated by CAPD.

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Section: Discussionmentioning

confidence: 78%

Section: Discussionmentioning

confidence: 99%

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Intraperitoneal administration of recombinant human erythropoietin in children on continuous ambulatory peritoneal dialysis

1992

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“…We, as well as others [ 1,[6][7][8][9], have shown that low-dose subcutaneously administered rhEPO is ef fective in treating the anemia of ESRD. Intraperitoneal administration, though effective, is costly, requiring doses 5 to 10 times that used subcutaneously [10][11][12], In addi tion, an increased frequency of peritonitis has been ob served with intraperitoneal administration [13,14].…”

Section: Discussionmentioning

confidence: 99%

Efficacy of Once- versus Thrice-Weekly Subcutaneous Recombinant Human Erythropoietin in Children Receiving Continuous Cycling Peritoneal Dialysis

Ongkingco

Ruley²,

Turner³

et al. 1994

Am J Nephrol

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The subcutaneous administration of recombinant human erythropoietin is effective in the treatment of anemia of end-stage renal disease. Single-dose pharmacokinetic studies suggest the possibility of less frequent dosing via the subcutaneous route. In this study, dosing once-weekly was as effective as thrice-weekly subcutaneous dosing in maintaining the corrected hematocrit in a group of children receiving continuous cycling peritoneal dialysis. This regimen was preferred by and benificial to both patients and their parents.

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Pharmacokinetics and Metabolism of Hematopoietic Proteins

Stoudemire

1992

Pharmaceutical Biotechnology

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Intraperitoneal Erythropoietin

Cited by 4 publications

References 2 publications

Intraperitoneal administration of recombinant human erythropoietin in children on continuous ambulatory peritoneal dialysis

Intraperitoneal administration of recombinant human erythropoietin in children on continuous ambulatory peritoneal dialysis

Efficacy of Once- versus Thrice-Weekly Subcutaneous Recombinant Human Erythropoietin in Children Receiving Continuous Cycling Peritoneal Dialysis

Pharmacokinetics and Metabolism of Hematopoietic Proteins

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