Intraperitoneal Echinococcus multilocularis infection in mice modulates peritoneal CD4+ and CD8+ regulatory T cell development

Mejri, Naceur; Müller, Norbert; Hemphill, Andrew; Gottstein, Bruno

doi:10.1016/j.parint.2010.10.002

Cited by 50 publications

(68 citation statements)

References 47 publications

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“…The most widely described suppressor T cells are CD4+CD25+ T cells. At the late stage of experimental infection, a five-fold increase in CD4+CD25+ T cells in infected mice became apparent, when compared to non-infected mice (Mejri et al, 2011a). Foxp3, a marker for Treg cells, was expressed at higher levels in CD4 T cells and CD8+ T cells of AE-infected mice when compared to non-infected mice.…”

Section: Biology and Immunology Of Susceptibility Versus Resistance Imentioning

confidence: 94%

“…Subsequent series of experiments showed that CD4+ T cell hyporesponsiveness was associated with differentiation of Treg cells (Mejri et al, 2011a). The most widely described suppressor T cells are CD4+CD25+ T cells.…”

Section: Biology and Immunology Of Susceptibility Versus Resistance Imentioning

confidence: 99%

“…Principally, upon experimental infection, immunocompetent mice elicit a cell-mediated immune response, which is so far inefficient as it impairs, but does not inhibit, the proliferation of the metacestode (Dai et al, 2004;Mejri et al, 2010). It has been shown that the type of the primary immune response toward infection, initially Th1-oriented, got progressively Th2-oriented (Mejri et al, 2011a) during the progressive growth of the metacestode, leading to the chronic stage of AE. Concomitantly, intraperitoneal dendritic cells (DCs) and T cells isolated at this late stage of infection expressed relatively high levels of TGF-␤ mRNA, while IFN-␥ mRNA, and the surface expression of the major costimulatory molecules CD80, CD86, CD40 and the MHC class II (Ia) molecules were downregulated (Mejri et al, 2011a,b).…”

Section: Biology and Immunology Of Susceptibility Versus Resistance Imentioning

confidence: 99%

See 2 more Smart Citations

Susceptibility versus resistance in alveolar echinococcosis (larval infection with Echinococcus multilocularis)

Gottstein

Wang

Boubaker

et al. 2015

Veterinary Parasitology

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Epidemiological studies have demonstrated that the majority of human individuals exposed to infection with Echinococcus spp. eggs exhibit resistance to disease as shown by either seroconversion to parasite--specific antigens, and/or the presence of 'dying out' or 'aborted' metacestodes, not including hereby those individuals who putatively got infected but did not seroconvert and who subsequently allowed no development of the pathogen. For those individuals where infection leads to disease, the developing parasite is partially controlled by host immunity. In infected humans, the type of immune response developed by the host accounts for the subsequent trichotomy concerning the parasite development: (i) seroconversion proving infection, but lack of any hepatic lesion indicating the failure of the parasite to establish and further develop within the liver; or resistance as shown by the presence of fully calcified lesions; (ii) controlled susceptibility as found in the "conventional" alveolar echinococcosis (AE) patients who experience clinical signs and symptoms approximately 5-15 years after infection, and (iii) uncontrolled hyperproliferation of the metacestode due to an impaired immune response (AIDS or other immunodeficiencies). Immunomodulation of host immunity toward anergy seems to be triggered by parasite metabolites. Beside immunomodulating IL-10, TGFβ-driven regulatory T cells have been shown to play a crucial role in the parasite-modulated progressive course of AE. A novel CD4+CD25+ Treg effector molecule FGL2 recently yielded new insight into the tolerance process in Echinococcus multilocularis infection.

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Section: Biology and Immunology Of Susceptibility Versus Resistance Imentioning

confidence: 94%

Section: Biology and Immunology Of Susceptibility Versus Resistance Imentioning

confidence: 99%

Section: Biology and Immunology Of Susceptibility Versus Resistance Imentioning

confidence: 99%

See 1 more Smart Citation

Susceptibility versus resistance in alveolar echinococcosis (larval infection with Echinococcus multilocularis)

Gottstein

Wang

Boubaker

et al. 2015

Veterinary Parasitology

Self Cite

View full text Add to dashboard Cite

show abstract

“…multilocularis infection in mice induced DC expressing high levels TGF and very low levels of IL-10 and IL-12, and the expression of the surface markers CD80, CD86 and CD40 was down-regulated (Mejri et al, 2011a;Mejri et al, 2011b). However, the higher level of IL-4 than IFN-γ/IL-2 mRNA-expression in AE-CD4+ pT cells indicated DC play a role in the generation of a regulatory immune response (Mejri et al, 2011a).…”

Section: Dendritc Cellsmentioning

confidence: 99%

“…The high expression levels of Foxp3 mRNA by CD4+ and CD8+ peritoneal T cells suggested that subpopulations of regulatory CD4+ Foxp3+ and CD8+ Foxp3+ T cells were involved in modulating the immune responses in the chronic stage of AE, which are Th2 polarized responses (Mejri et al, 2011b).…”

Section: Regulatory T Cellsmentioning

confidence: 99%